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Proteins/UNIPROT:A5YM72

CARNS1

Protein·UNIPROT:A5YM72Carnosine synthase 11 compound

Open in the graph

Catalyzes the synthesis of carnosine and homocarnosine. Carnosine is synthesized more efficiently than homocarnosine..

Function from UniProtKB (A5YM72), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 1 · substrate of

Inferred

Assembled routes, not reported.

What routes through it

1 compound

1 compound.

0 reported routes1 assembled route

beta-alanineCompoundCHEBI:57966Inferred only8 paths4 endpoints

What the reference databases state

Statements

35 statements

35 statements · 8 reference databases · Subject: CARNS1 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways

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CARNS1 covaries with CIMIP6ProteinHetionet hetionet:covaries:129852-57571Inferred only
CARNS1 covaries with ZNF180ProteinHetionet hetionet:covaries:57571-7733Inferred only
CARNS1 is expressed in C1 segment of cervical spinal cordAnatomyBgee ENSG00000172508Inferred only
CARNS1 is expressed in cerebellumAnatomyHuman Protein Atlas ENSG00000172508Inferred only
CARNS1 is expressed in cerebral cortexAnatomyHuman Protein Atlas ENSG00000172508Inferred only
CARNS1 is expressed in globus pallidusAnatomyBgee ENSG00000172508Inferred only
CARNS1 is expressed in inferior vagus X ganglionAnatomyBgee ENSG00000172508Inferred only
CARNS1 is expressed in lateral globus pallidusAnatomyBgee ENSG00000172508Inferred only
CARNS1 is expressed in lateral nuclear group of thalamusAnatomyBgee ENSG00000172508Inferred only
CARNS1 is expressed in medial globus pallidusAnatomyBgee ENSG00000172508Inferred only
CARNS1 is expressed in medulla oblongataAnatomyBgee ENSG00000172508Inferred only
CARNS1 is expressed in midbrainAnatomyBgee ENSG00000172508Inferred only

Show the remaining 23

CARNS1 is expressed in ponsAnatomyBgee ENSG00000172508Inferred only
CARNS1 is expressed in spinal cordAnatomyBgee ENSG00000172508Inferred only
CARNS1 is expressed in substantia nigraAnatomyBgee ENSG00000172508Inferred only
CARNS1 is expressed in substantia nigra pars compactaAnatomyBgee ENSG00000172508Inferred only
CARNS1 is expressed in substantia nigra pars reticulataAnatomyBgee ENSG00000172508Inferred only
CARNS1 is expressed in subthalamic nucleusAnatomyBgee ENSG00000172508Inferred only
CARNS1 is expressed in superior vestibular nucleusAnatomyBgee ENSG00000172508Inferred only
CARNS1 is expressed in ventral tegmental areaAnatomyBgee ENSG00000172508Inferred only
TRIP12 interacts with CARNS1ProteinHetionet hetionet:interacts:57571-9320Inferred only
CARNS1 participates in Carnosine metabolism of glial cellsPathwayWikiPathways WP5313Inferred only
CARNS1 participates in Histidine catabolismPathwayReactome R-HSA-70921Inferred only
CARNS1 participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
CARNS1 participates in Metabolism of amino acids and derivativesPathwayReactome R-HSA-71291Inferred only
CARNS1 requires the cofactor magnesium(2+)CompoundUniProt A5YM72Inferred only
CARNS1 requires the cofactor Mn(2+)CompoundUniProt A5YM72Inferred only
4-aminobutanoate is a substrate of CARNS1CompoundHuman-GEM MAR04606Inferred only
4-aminobutanoate is a substrate of CARNS1CompoundRhea RHEA:59568Inferred only
beta-alanine is a substrate of CARNS1CompoundHuman-GEM MAR04425Inferred only
beta-alanine is a substrate of CARNS1CompoundRhea RHEA:19297Inferred only
CHEBI:15971 is a substrate of CARNS1CompoundHuman-GEM MAR04425Inferred only
CHEBI:15971 is a substrate of CARNS1CompoundHuman-GEM MAR04606Inferred only
L-histidine is a substrate of CARNS1CompoundRhea RHEA:19297Inferred only
L-histidine is a substrate of CARNS1CompoundRhea RHEA:59568Inferred only

Reactions

4 reactions

ATP+beta-alanine+CHEBI:15971AMP+CHEBI:15727+proton+diphosphate(3-)
Catalysed by CARNS1
Reaction pageLeft to rightBalancedEC 6.3.2.11cytosol
Human-GEM MAR04425CC BY 4.0Reference data
4-aminobutanoate+ATP+CHEBI:15971AMP+

Other names

3 names

Resolves to: CARNS1

Also called: ATP-grasp domain-containing protein 1ATPGD1KIAA1394

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+L-homocarnosine

+diphosphate(3-)

Catalysed by CARNS1

Reaction pageLeft to rightBalancedEC 6.3.2.11cytosol

Human-GEM MAR04606CC BY 4.0Reference data

beta-alanine+L-histidine+ATP(4-)carnosine+ADP(3-)+hydrogenphosphate+hydron

Catalysed by CARNS1

Reaction pageLeft to rightBalanced

Rhea RHEA:19297CC BY 4.0Reference data

4-aminobutanoate+L-histidine+ATP(4-)L-homocarnosine+ADP(3-)+hydrogenphosphate+hydron

Catalysed by CARNS1

Reaction pageLeft to rightBalanced

Rhea RHEA:59568CC BY 4.0Reference data