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Proteins/UNIPROT:P43353
Oxidizes medium and long chain saturated and unsaturated fatty aldehydes generated in the plasma membrane into non-toxic fatty acids. May have a protective role against the cytotoxicity induced by lipid peroxidation. Short-chain fatty aldehydes are not good substrates. Can use both NADP(+) and NAD(+) as electron acceptor in vitro, however in vivo preference will depend on their tissue levels. Low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde. Able to metabolize aromatic aldehydes such as benzaldehyde to their acid form..
Function from UniProtKB (P43353), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
145 statements
145 statements · 5 reference databases · Subject: ALDH3B1 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea
57 reactions
acetaldehyde+water+NAD(+)acetate+2proton+NADH(2-)
Catalysed by ALDH3B1 or ALDH3A1 or ALDH3B2 or ALDH1A3
Reaction pageLeft to rightBalancedEC 1.2.1.4, 1.2.1.5cytosol
Human-GEM MAR01568CC BY 4.0Reference data
4 names
Resolves to: ALDH3B1
Reaction pageReversibleBalancedEC 1.2.1.5mitochondrial matrix
Human-GEM MAR02188CC BY 4.0Reference data
MAM00726m+water+NADP(3-)MAM00727m+2proton+NADPH(4-)
Catalysed by ALDH3B1 or ALDH3A1 or ALDH3B2
Reaction pageLeft to rightBalancedEC 1.2.1.5mitochondrial matrix
Human-GEM MAR02189CC BY 4.0Reference data
MAM00818m+water+NAD(+)2proton+MAM02137m+NADH(2-)
Catalysed by ALDH3B1 or ALDH3A1 or ALDH3B2 or ALDH1A3
Reaction pageReversibleBalancedEC 1.2.1.5mitochondrial matrix
Human-GEM MAR02192CC BY 4.0Reference data
MAM00818m+water+NADP(3-)2proton+MAM02137m+NADPH(4-)
Catalysed by ALDH3B1 or ALDH3A1 or ALDH3B2
Reaction pageLeft to rightBalancedEC 1.2.1.5mitochondrial matrix
Human-GEM MAR02195CC BY 4.0Reference data
MAM00820m+water+NAD(+)2proton+NADH(2-)+MAM03136m
Catalysed by ALDH3B1 or ALDH3A1 or ALDH3B2 or ALDH1A3
Reaction pageReversibleBalancedEC 1.2.1.5mitochondrial matrix
Human-GEM MAR02196CC BY 4.0Reference data
MAM00820m+water+NADP(3-)2proton+NADPH(4-)+MAM03136m
Catalysed by ALDH3B1 or ALDH3A1 or ALDH3B2
Reaction pageLeft to rightBalancedEC 1.2.1.5mitochondrial matrix
Human-GEM MAR02197CC BY 4.0Reference data
acetaldehyde+water+NADP(3-)acetate+2proton+NADPH(4-)
Catalysed by ALDH3B1 or ALDH3A1 or ALDH3B2
Reaction pageLeft to rightBalancedEC 1.2.1.5cytosol
Human-GEM MAR04283CC BY 4.0Reference data
water+1-methylimidazole-4-acetaldehyde+NAD(+)2proton+MAM02477c+NADH(2-)
Catalysed by ALDH3B1 or ALDH3A1 or ALDH3B2 or ALDH1A3
Reaction pageLeft to rightBalancedEC 1.2.1.5cytosol
Human-GEM MAR04431CC BY 4.0Reference data
water+NAD(+)+2-phenylacetaldehyde2proton+NADH(2-)+MAM02720c
Catalysed by ALDH3B1 or ALDH3A1 or ALDH3B2
Reaction pageLeft to rightBalancedEC 1.2.1.5, 1.2.1.39cytosol
Human-GEM MAR04683CC BY 4.0Reference data
water+NAD(+)+2-phenylacetaldehyde2proton+NADH(2-)+MAM02720m
Catalysed by ALDH3B1 or ALDH3A1 or ALDH3B2
Reaction pageLeft to rightBalancedEC 1.2.1.5, 1.2.1.39mitochondrial matrix
Human-GEM MAR04685CC BY 4.0Reference data
2proton+NADPH(4-)+MAM02720cwater+NADP(3-)+2-phenylacetaldehyde
Catalysed by ALDH3B1 or ALDH3A1 or ALDH3B2
Reaction pageReversibleBalancedEC 1.2.1.5cytosol
Human-GEM MAR04686CC BY 4.0Reference data