Loading the page.
Proteins/UNIPROT:Q04760
Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B. Required for normal osteoclastogenesis (By similarity)..
Function from UniProtKB (Q04760), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
217 statements
217 statements · 8 reference databases · Subject: GLO1 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt
2 reactions
CHEBI:16856+methylglyoxal(R)-S-lactoylglutathione
Reaction pageLeft to rightBalancedEC 4.4.1.5cytosol
Human-GEM MAR03853CC BY 4.0Reference data
(R)-S-lactoylglutathionemethylglyoxal+glutathione
Catalysed by GLO1
Reaction pageRight to leftBalanced
Rhea RHEA:19069CC BY 4.0Reference data
6 names
Resolves to: GLO1