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Proteins/UNIPROT:Q13510
Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. Has a higher catalytic efficiency towards C12-ceramides versus other ceramides. Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatty acids and sphingosine. For the reverse synthetic reaction, the natural sphingosine D-erythro isomer is more efficiently utilized as a substrate compared to D-erythro-dihydrosphingosine and D-erythro-phytosphingosine, while the fatty acids with chain lengths of 12 or 14 carbons are the most efficiently used. Also has an N-acylethanolamine hydrolase activity. By regulating the levels of ceramides, sphingosine and sphingosine-1-phosphate in the epidermis, mediates the calcium-induced differentiation of epidermal keratinocytes. Also indirectly regulates tumor necrosis factor/TNF-induced apoptosis (By similarity). By regulating the intracellular balance between ceramides and sphingosine, in adrenocortical cells, probably also acts as a regulator of steroidogenesis..
[Isoform 2]: May directly regulate steroidogenesis by binding the nuclear receptor NR5A1 and negatively regulating its transcriptional activity..
Function from UniProtKB (Q13510), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
3 rows
374 statements
374 statements · 8 reference databases · Subject: ASAH1 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways · Rows fetched: 300
19 reactions
water+an N-acyl-(4R)-4-hydroxysphinganine(4R)-hydroxysphinganine+fatty acid
Catalysed by ACER3 or ASAH1 or ACER1 or ACER2 or ASAH2
Reaction pageLeft to rightBalance undeterminableEC 3.5.1.23cytosol
Human-GEM MAR00716CC BY 4.0Reference data
11 names
Resolves to: ASAH1
Reaction pageLeft to rightBalance undeterminableEC 3.5.1.23Golgi apparatus
Human-GEM MAR00733CC BY 4.0Reference data
an N-acylsphinganine+waterCHEBI:16566+fatty acid
Catalysed by ACER3 or ASAH1 or ACER1 or ACER2 or ASAH2
Reaction pageReversibleBalance undeterminableEC 3.5.1.23cytosol
Human-GEM MAR00753CC BY 4.0Reference data
an N-acylsphing-4-enine+watersphing-4-enine+fatty acid
Catalysed by ASAH1
Reaction pageLeft to rightBalance undeterminableEC 3.5.1.23lysosome
Human-GEM MAR08211CC BY 4.0Reference data
an N-acylsphing-4-enine+watersphing-4-enine+a fatty acid
Catalysed by NAAA or ASAH1 or ACER2 or ACER1 or ASAH2 or ACER3
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:20856CC BY 4.0Reference data
a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine+waterbeta-D-glucosyl-(1<->1)-sphing-4-enine+a fatty acid
Catalysed by ASAH1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:30915CC BY 4.0Reference data
N-hexadecanoylsphing-4-enine+watersphing-4-enine+hexadecanoate
Catalysed by NAAA or ASAH1 or ACER2 or ASAH2
Reaction pageReversibleBalanced
Rhea RHEA:38891CC BY 4.0Reference data
N-octadecanoylsphing-4-enine+watersphing-4-enine+octadecanoate
Catalysed by ASAH1 or ACER2 or ASAH2
Reaction pageReversibleBalanced
Rhea RHEA:41279CC BY 4.0Reference data
N-tetradecanoylsphing-4-enine+watersphing-4-enine+tetradecanoate
Catalysed by ASAH1 or ACER2 or ASAH2
Reaction pageReversibleBalanced
Rhea RHEA:41287CC BY 4.0Reference data
N-dodecanoylsphing-4-enine+waterdodecanoate+sphing-4-enine
Catalysed by NAAA or ASAH1 or ACER2 or ASAH2
Reaction pageReversibleBalanced
Rhea RHEA:41291CC BY 4.0Reference data
N-(hexanoyl)sphing-4-enine+waterhexanoate+sphing-4-enine
Catalysed by ASAH1 or ACER2 or ASAH2
Reaction pageLeft to rightBalanced
Rhea RHEA:41295CC BY 4.0Reference data
N-(9Z-octadecenoyl)-sphing-4-enine+watersphing-4-enine+(9Z)-octadecenoate
Catalysed by ASAH1 or ACER2 or ACER1 or ASAH2 or ACER3
Reaction pageReversibleBalanced
Rhea RHEA:41299CC BY 4.0Reference data