Compound
succinate semialdehyde
The conjugate base of 4-oxobutanoic acid; major species at pH 7.3.
Definition from ChEBI (CHEBI:57706), read 2026-09-23. CC BY 4.0.
Structure
Loading the model…
- Class
- Organic compound, anion
- Formula
- C4H5O3
- Mass
- 101.081 g/mol
- Charge
- -1
- InChIKey
- UIUJIQZEACWQSV-UHFFFAOYSA-M
- SMILES
- O=CCCC(=O)[O-]
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
3 entities
3 entities reached.
What the reference databases state
Statements
12 statements
12 statements · 1 reference database · Subject: succinate semialdehyde · Sources: Rhea
- 4-aminobutanoate is converted to succinate semialdehydeCompoundRhea RHEA:61280Inferred only
- succinate semialdehyde is converted to 4-aminobutanoateCompoundRhea RHEA:61280Inferred only
- 4-aminobutanoate is converted to succinate semialdehydeCompoundRhea RHEA:23352Inferred only
- succinate semialdehyde is converted to 4-hydroxybutanoateCompoundRhea RHEA:23948Inferred only
- 4-hydroxybutanoate is converted to succinate semialdehydeCompoundRhea RHEA:23948Inferred only
- 4-hydroxybutanoate is converted to succinate semialdehydeCompoundRhea RHEA:26381Inferred only
- succinate semialdehyde is converted to 4-hydroxybutanoateCompoundRhea RHEA:26381Inferred only
- succinyl-CoA is converted to succinate semialdehydeCompoundRhea RHEA:26450Inferred only
- succinate semialdehyde is converted to succinyl-CoACompoundRhea RHEA:26450Inferred only
- succinate semialdehyde is metabolised by ALDH5A1ProteinRhea RHEA:13217Inferred only
- succinate semialdehyde is a substrate of ADHFE1ProteinRhea RHEA:24734Inferred only
- succinate semialdehyde is a substrate of AKR7A2ProteinRhea RHEA:26381Inferred only
Reactions
17 reactions
CHEBI:57698+2water+hydronsuccinate semialdehyde+acetate+ammonium+carbon dioxide
Reaction pageDirection not assertedBalanced
Rhea RHEA:10432CC BY 4.0Reference data
2-oxoglutarate(2-)+hydronsuccinate semialdehyde+carbon dioxide
Reaction pageDirection not assertedBalanced
Rhea RHEA:10524CC BY 4.0Reference data
succinate semialdehyde+NADP(3-)+watersuccinate(2-)+NADPH(4-)+2hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:13213CC BY 4.0Reference data
succinate semialdehyde+NAD(1-)+watersuccinate(2-)+NADH(2-)+2hydron
Catalysed by ALDH5A1
Reaction pageLeft to rightBalanced
Rhea RHEA:13217CC BY 4.0Reference data
4-aminobutanoate+2-oxoglutarate(2-)succinate semialdehyde+L-glutamate(1-)
Catalysed by ABAT
Reaction pageLeft to rightBalanced
Rhea RHEA:23352CC BY 4.0Reference data
4-hydroxybutanoate+NAD(1-)succinate semialdehyde+NADH(2-)+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:23948CC BY 4.0Reference data
4-hydroxybutanoate+2-oxoglutarate(2-)(R)-2-hydroxyglutarate+succinate semialdehyde
Catalysed by ADHFE1
Reaction pageDirection not assertedBalanced
Rhea RHEA:24734CC BY 4.0Reference data
CHEBI:73036succinate semialdehyde+pyruvate
Reaction pageDirection not assertedBalanced
Rhea RHEA:25788CC BY 4.0Reference data
4-hydroxybutanoate+NADP(3-)succinate semialdehyde+NADPH(4-)+hydron
Catalysed by AKR7A2
Reaction pageDirection not assertedBalanced
Rhea RHEA:26381CC BY 4.0Reference data
succinate semialdehyde+NADP(3-)+coenzyme A(4-)succinyl-CoA+NADPH(4-)+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:26450CC BY 4.0Reference data
4-aminobutanoate+pyruvatesuccinate semialdehyde+L-alanine
Reaction pageDirection not assertedBalanced
Rhea RHEA:32263CC BY 4.0Reference data
4-aminobutanoate+glyoxylatesuccinate semialdehyde+glycine
Reaction pageDirection not assertedBalanced
Rhea RHEA:32267CC BY 4.0Reference data
Other names
1 name
Resolves to: succinate semialdehyde
- Systematic name
- 4-oxobutanoate