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Proteins/UNIPROT:Q8TCG5
Palmitoyl thioesterase specifically expressed in the endoplasmic reticulum of neurons. Modulates the trafficking of the glutamate receptor, AMPAR, to plasma membrane through depalmitoylation of GRIA1. Also regulates AMPR trafficking through the regulation of SACM1L phosphatidylinositol-3-phosphatase activity by interaction in a malonyl-CoA dependent manner (By similarity). Binds malonyl-CoA and couples malonyl-CoA to ceramide levels, necessary for proper spine maturation and contributing to systemic energy homeostasis and appetite control. Binds to palmitoyl-CoA, but does not have carnitine palmitoyltransferase 1 catalytic activity or at very low levels..
Function from UniProtKB (Q8TCG5), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
333 statements
333 statements · 5 reference databases · Subject: CPT1C · Sources: Bgee, gene ontology, Hetionet, Human-GEM, WikiPathways · Rows fetched: 300
96 reactions
(2E)-hexadecenoyl-CoA+(S)-carnitineCHEBI:1146900+MAM02117c
Catalysed by CPT1A or CPT1C or CPT1B
Reaction pageReversibleBalancedEC 2.3.1.21cytosol
Human-GEM MAR00103CC BY 4.0Reference data
(S)-carnitine+oleoyl-CoACHEBI:1146900+MAM02639c
6 names
Resolves to: CPT1C
Reaction pageReversibleBalancedEC 2.3.1.21cytosol
Human-GEM MAR00108CC BY 4.0Reference data
butanoyl-CoA+(S)-carnitineCHEBI:1146900+MAM02635c
Catalysed by CPT1A or CPT1C or CPT1B
Reaction pageReversibleBalancedEC 2.3.1.21cytosol
Human-GEM MAR00159CC BY 4.0Reference data
(2E)-octadecenoyl-CoA+(S)-carnitineMAM00126c+CHEBI:1146900
Catalysed by CPT1A or CPT1C or CPT1B
Reaction pageReversibleBalancedEC 2.3.1.21cytosol
Human-GEM MAR00452CC BY 4.0Reference data
CHEBI:1146900+O-acetyl-(R)-carnitineCHEBI:15351+(S)-carnitine
Catalysed by CPT1A or CPT1C or CPT1B
Reaction pageReversibleBalancedEC 2.3.1.21cytosol
Human-GEM MAR02591CC BY 4.0Reference data
CHEBI:1146900+MAM02657c(S)-carnitine+propionyl-CoA
Catalysed by CPT1A or CPT1C or CPT1B
Reaction pageReversibleBalancedEC 2.3.1.21cytosol
Human-GEM MAR02594CC BY 4.0Reference data
CHEBI:1146900+MAM02443c(S)-carnitine+malonyl-CoA
Catalysed by CPT1A or CPT1C or CPT1B
Reaction pageReversibleBalancedEC 2.3.1.21cytosol
Human-GEM MAR02599CC BY 4.0Reference data
CHEBI:1146900+O-dodecanoyl-R-carnitinedodecanoyl-CoA+(S)-carnitine
Catalysed by CPT1A or CPT1C or CPT1B
Reaction pageReversibleBalancedEC 2.3.1.21cytosol
Human-GEM MAR02602CC BY 4.0Reference data
CHEBI:1146900+MAM03049c(S)-carnitine+MAM03050c
Catalysed by CPT1A or CPT1C or CPT1B
Reaction pageReversibleBalancedEC 2.3.1.21cytosol
Human-GEM MAR02605CC BY 4.0Reference data
CHEBI:1146900+MAM02973c(S)-carnitine+tetradecanoyl-CoA
Catalysed by CPT1A or CPT1C or CPT1B
Reaction pageReversibleBalancedEC 2.3.1.21cytosol
Human-GEM MAR02608CC BY 4.0Reference data
MAM00129c+(S)-carnitineCHEBI:1146900+(5E)-tetradecenoyl-(R)-carnitine
Catalysed by CPT1A or CPT1C or CPT1B
Reaction pageReversibleBalancedEC 2.3.1.21cytosol
Human-GEM MAR02611CC BY 4.0Reference data
(7Z)-tetradecenoyl-CoA+(S)-carnitineCHEBI:1146900+MAM02975c
Catalysed by CPT1A or CPT1C or CPT1B
Reaction pageReversibleBalancedEC 2.3.1.21cytosol
Human-GEM MAR02614CC BY 4.0Reference data