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Proteins/UNIPROT:Q8TBG4

ETNPPL

Protein·UNIPROT:Q8TBG4Ethanolamine-phosphate phospho-lyase

Open in the graph

Catalyzes the pyridoxal-phosphate-dependent breakdown of phosphoethanolamine, converting it to ammonia, inorganic phosphate and acetaldehyde..

Function from UniProtKB (Q8TBG4), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

51 statements

51 statements · 7 reference databases · Subject: ETNPPL · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt

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FAM185A covaries with ETNPPLProteinHetionet hetionet:covaries:222234-64850Inferred only
MDC1 covaries with ETNPPLProteinHetionet hetionet:covaries:64850-9656Inferred only
ETNPPL covaries with SLCO1B1ProteinHetionet hetionet:covaries:10599-64850Inferred only
ZSCAN12 covaries with ETNPPLProteinHetionet hetionet:covaries:64850-9753Inferred only
ETNPPL is expressed in Ammon's hornAnatomyHuman Protein Atlas ENSG00000164089Inferred only
ETNPPL is expressed in Ammon's hornAnatomyBgee ENSG00000164089Inferred only
ETNPPL is expressed in amygdalaAnatomyBgee ENSG00000164089Inferred only
ETNPPL is expressed in anterior cingulate cortexAnatomyBgee ENSG00000164089Inferred only
ETNPPL is expressed in Brodmann (1909) area 23AnatomyBgee ENSG00000164089Inferred only
ETNPPL is expressed in Brodmann (1909) area 9AnatomyBgee ENSG00000164089Inferred only
ETNPPL is expressed in CA1 field of hippocampusAnatomyBgee ENSG00000164089Inferred only
ETNPPL is expressed in caudate nucleusAnatomyBgee ENSG00000164089Inferred only

Show the remaining 39

ETNPPL is expressed in caudate nucleusAnatomyHuman Protein Atlas ENSG00000164089Inferred only
ETNPPL is expressed in cerebellumAnatomyHuman Protein Atlas ENSG00000164089Inferred only
ETNPPL is expressed in cerebral cortexAnatomyHuman Protein Atlas ENSG00000164089Inferred only
ETNPPL is expressed in cranial nerve IIAnatomyBgee ENSG00000164089Inferred only
ETNPPL is expressed in dorsal motor nucleus of vagus nerveAnatomyBgee ENSG00000164089Inferred only
ETNPPL is expressed in entorhinal cortexAnatomyBgee ENSG00000164089Inferred only
ETNPPL is expressed in globus pallidusAnatomyBgee ENSG00000164089Inferred only
ETNPPL is expressed in hypothalamusAnatomyBgee ENSG00000164089Inferred only
ETNPPL is expressed in lateral globus pallidusAnatomyBgee ENSG00000164089Inferred only
ETNPPL is expressed in liverAnatomyHuman Protein Atlas ENSG00000164089Inferred only
ETNPPL is expressed in medial globus pallidusAnatomyBgee ENSG00000164089Inferred only
ETNPPL is expressed in medulla oblongataAnatomyBgee ENSG00000164089Inferred only
ETNPPL is expressed in midbrainAnatomyBgee ENSG00000164089Inferred only
ETNPPL is expressed in nucleus accumbensAnatomyBgee ENSG00000164089Inferred only
ETNPPL is expressed in parotid glandAnatomyBgee ENSG00000164089Inferred only
ETNPPL is expressed in putamenAnatomyBgee ENSG00000164089Inferred only
ETNPPL is expressed in right frontal lobeAnatomyBgee ENSG00000164089Inferred only
ETNPPL is expressed in saliva-secreting glandAnatomyHuman Protein Atlas ENSG00000164089Inferred only
ETNPPL is expressed in stomachAnatomyHuman Protein Atlas ENSG00000164089Inferred only
ETNPPL is expressed in substantia nigraAnatomyBgee ENSG00000164089Inferred only
ETNPPL is expressed in substantia nigra pars compactaAnatomyBgee ENSG00000164089Inferred only
ETNPPL is expressed in substantia nigra pars reticulataAnatomyBgee ENSG00000164089Inferred only
ETNPPL is expressed in subthalamic nucleusAnatomyBgee ENSG00000164089Inferred only
ETNPPL is expressed in superior vestibular nucleusAnatomyBgee ENSG00000164089Inferred only
ETNPPL is expressed in temporal lobeAnatomyBgee ENSG00000164089Inferred only
ETNPPL is expressed in ventral tegmental areaAnatomyBgee ENSG00000164089Inferred only
APP interacts with ETNPPLProteinHetionet hetionet:interacts:351-64850Inferred only
UBC interacts with ETNPPLProteinHetionet hetionet:interacts:64850-7316Inferred only
ETNPPL participates in Glycerophospholipid biosynthesisPathwayReactome R-HSA-1483206Inferred only
ETNPPL participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
ETNPPL participates in Metabolism of lipidsPathwayReactome R-HSA-556833Inferred only
ETNPPL participates in Phospholipid metabolismPathwayReactome R-HSA-1483257Inferred only
ETNPPL participates in Synthesis of PEPathwayReactome R-HSA-1483213Inferred only
ADH5 increases the expression of ETNPPLProteinHetionet hetionet:regulates:128-64850Inferred only
PROX1 increases the expression of ETNPPLProteinHetionet hetionet:regulates:5629-64850Inferred only
ETNPPL requires the cofactor pyridoxal 5'-phosphateCompoundUniProt Q8TBG4Inferred only
acetaldehyde is a substrate of ETNPPLCompoundRhea RHEA:17889Inferred only
O-phosphoethanolamine is a substrate of ETNPPLCompoundHuman-GEM MAR04296Inferred only
phosphoethanolamine is a substrate of ETNPPLCompoundRhea RHEA:17889Inferred only

Reactions

2 reactions

O-phosphoethanolamine+wateracetaldehyde+proton+ammonium+phosphate(3-)
Catalysed by ETNPPL
Reaction pageLeft to rightBalancedEC 4.2.3.2cytosol
Human-GEM MAR04296CC BY 4.0Reference data
phosphoethanolamine+wateracetaldehyde+ammonium+hydrogenphosphate
Catalysed by

Other names

2 names

Resolves to: ETNPPL

Also called: AGXT2L1Alanine--glyoxylate aminotransferase 2-like 1

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Reaction pageDirection not assertedBalanced

Rhea RHEA:17889CC BY 4.0Reference data