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Proteins/UNIPROT:Q8N5Z0
Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro)..
Function from UniProtKB (Q8N5Z0), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 4 · substrate of
4 compounds
4 compounds.
0 reported routes4 assembled routes
72 statements
72 statements · 7 reference databases · Subject: AADAT · Sources: Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
27 reactions
2-oxoglutarate(2-)+L-kynureninekynurenate+L-glutamate(1-)+water
Reaction pageLeft to rightBalancedEC 2.6.1.7mitochondrial matrix
Human-GEM MAR02765CC BY 4.0Reference data
CHEBI:17380+2-oxoglutarate(2-)L-glutamate(1-)+water+xanthurenate
Catalysed by
13 names
Resolves to: AADAT
Reaction pageReversibleBalancedEC 2.6.1.7mitochondrial matrix
Human-GEM MAR03048CC BY 4.0Reference data
L-glutamine+pyruvate2-oxoglutaramate+L-alanine
Reaction pageLeft to rightBalancedEC 2.6.1.15, 2.6.1.63mitochondrial matrix
Human-GEM MAR04197CC BY 4.0Reference data
CHEBI:17380+2-oxoglutarate(2-)4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate+L-glutamate(1-)
Catalysed by AADAT or KYAT3 or KYAT1
Reaction pageLeft to rightBalancedEC 2.6.1.7cytosol
Human-GEM MAR04244CC BY 4.0Reference data
CHEBI:17380+2-oxoglutarate(2-)L-glutamate(1-)+water+xanthurenate
Catalysed by AADAT or KYAT3 or KYAT1
Reaction pageReversibleBalancedEC 2.6.1.7cytosol
Human-GEM MAR04246CC BY 4.0Reference data
2-oxoadipate+L-glutamate(1-)2-oxoglutarate(2-)+MAM02322c
Catalysed by AADAT
Reaction pageReversibleBalancedEC 2.6.1.39cytosol
Human-GEM MAR04596CC BY 4.0Reference data
2-oxoadipate+L-glutamate(1-)2-oxoglutarate(2-)+MAM02322m
Catalysed by AADAT
Reaction pageReversibleBalancedEC 2.6.1.39mitochondrial matrix
Human-GEM MAR04597CC BY 4.0Reference data
L-2-aminoadipate+2-oxoglutarate(2-)2-oxoadipate+L-glutamate(1-)
Catalysed by AADAT
Reaction pageLeft to rightBalanced
Rhea RHEA:12601CC BY 4.0Reference data
glycine+2-oxoglutarate(2-)glyoxylate+L-glutamate(1-)
Catalysed by AADAT
Reaction pageDirection not assertedBalanced
Rhea RHEA:14089CC BY 4.0Reference data
glyoxylate+L-methionine4-methylsulfanyl-2-oxobutanoate+glycine
Catalysed by AADAT
Reaction pageDirection not assertedBalanced
Rhea RHEA:22884CC BY 4.0Reference data
L-kynurenine+2-oxoglutarate(2-)kynurenate+L-glutamate(1-)+water
Catalysed by GOT2 or KYAT1 or KYAT3 or AADAT
Reaction pageLeft to rightBalanced
Rhea RHEA:65560CC BY 4.0Reference data
L-kynurenine+glyoxylatekynurenate+glycine+water
Reaction pageLeft to rightBalanced
Rhea RHEA:65896CC BY 4.0Reference data