(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

226 compounds within 3 steps: 4 in 1, 51 in 2, 171 in 3

One step

(5S)-hydroperoxy-(15S)-hydroxy-(6E,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + O2 = (5S)-hydroperoxy-(15S)-hydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate
Catalysed by ALOX5
15(S)-HPETEReach from here →
1. Glutathione: 15-HPETE oxidoreductase
Catalysed by GPX5, GPX1, GPX2, GPX3 and 5 morecytosol
CHEBI:16856Reach from here →
1. Glutathione: 15-HPETE oxidoreductase
Catalysed by GPX5, GPX1, GPX2, GPX3 and 5 morecytosol
15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. (15S)-15-Hydroxy-5,8,11-cis-13-trans-icosatetraenoate:NADP+ 15-oxidoreductase
No catalyst recordedcytosolOne of 3 routes

Two steps

tauroursodeoxycholateReach from here →
1. Glutathione: 15-HPETE oxidoreductase
2. transport of GSH and tauroursodeoxycholate (cytosol to extracellular)
Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, extracellular spaceOne of 2 routes
glycoursodeoxycholateReach from here →
1. Glutathione: 15-HPETE oxidoreductase
2. transport of glycoursodeoxycholate and GSH (cytosol to extracellular)
Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 more

cytosol, extracellular space

One of 2 routes

(15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoateReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 5 morecytosol

(11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoateReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 26 morecytosolOne of 4 routes

prostaglandin E3Reach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol, extracellular spaceOne of 2 routes

prostaglandin A2Reach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol, extracellular spaceOne of 2 routes

prostaglandin B1Reach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol, extracellular spaceOne of 2 routes

leukotriene F4Reach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 5 morecytosol, extracellular spaceOne of 2 routes

acetylcholineReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, extracellular spaceOne of 2 routes

CHEBI:15650Reach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol, extracellular spaceOne of 2 routes

bromideReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 22 morecytosolOne of 2 routes

lithocholic acidReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, extracellular spaceOne of 2 routes

bilirubin IXalphaReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, extracellular spaceOne of 2 routes

taurolithocholateReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, extracellular spaceOne of 2 routes

CHEBI:17208Reach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 5 morecytosol

homocysteineReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 5 morecytosol

L-cysteineReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 5 morecytosol

5(S)-HETEReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 5 morecytosolOne of 2 routes

CHEBI:28666Reach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol, extracellular spaceOne of 2 routes

glycocholateReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, extracellular spaceOne of 2 routes

cholateReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, extracellular spaceOne of 2 routes

(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 5 morecytosol, extracellular spaceOne of 2 routes

serotoninReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, extracellular spaceOne of 2 routes

taurocholateReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, extracellular spaceOne of 2 routes

glycolithocholic acidReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, extracellular spaceOne of 2 routes

gamma-Glu-AlaReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 11 morecytosol, extracellular space

3,3',5-triiodo-L-thyronineReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, extracellular spaceOne of 2 routes

prostaglandin E1Reach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol, extracellular spaceOne of 2 routes

prostaglandin I2Reach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol, extracellular spaceOne of 2 routes

prostaglandin F2alphaReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol, extracellular spaceOne of 2 routes

prostaglandin H2Reach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol, extracellular spaceOne of 2 routes

prostaglandin D2Reach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol, extracellular spaceOne of 2 routes

leukotriene A4Reach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol, extracellular spaceOne of 2 routes

(R)-S-lactoylglutathioneReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosolOne of 2 routes

S-formylglutathioneReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 11 morecytosol

leukotriene C4Reach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosolOne of 4 routes

glutathione disulfideReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 5 morecytosolOne of 14 routes

taurolithocholate 3-sulfateReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, extracellular spaceOne of 2 routes

histamineReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, extracellular spaceOne of 2 routes

L-thyroxineReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, extracellular spaceOne of 2 routes

S-sulfanylglutathioneReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol, mitochondrial matrix

dopamineReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, extracellular spaceOne of 2 routes

glycolithocholate 3-sulfateReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, extracellular spaceOne of 2 routes

prostaglandin E2Reach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, extracellular spaceOne of 2 routes

L-cysteinylglycineReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 11 morecytosolOne of 4 routes

(R)-noradrenalineReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, extracellular spaceOne of 2 routes