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Proteins/UNIPROT:P30838
ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids. Preferentially oxidizes aromatic aldehyde substrates. Comprises about 50 percent of corneal epithelial soluble proteins (By similarity). May play a role in preventing corneal damage caused by ultraviolet light (By similarity)..
Function from UniProtKB (P30838), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
81 statements
81 statements · 7 reference databases · Subject: ALDH3A1 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
31 reactions
acetaldehyde+water+NAD(+)acetate+2proton+NADH(2-)
Catalysed by ALDH3B1 or ALDH3A1 or ALDH3B2 or ALDH1A3
Reaction pageLeft to rightBalancedEC 1.2.1.4, 1.2.1.5cytosol
Human-GEM MAR01568CC BY 4.0Reference data
4 names
Resolves to: ALDH3A1
Reaction pageReversibleBalancedEC 1.2.1.5mitochondrial matrix
Human-GEM MAR02188CC BY 4.0Reference data
MAM00726m+water+NADP(3-)MAM00727m+2proton+NADPH(4-)
Catalysed by ALDH3B1 or ALDH3A1 or ALDH3B2
Reaction pageLeft to rightBalancedEC 1.2.1.5mitochondrial matrix
Human-GEM MAR02189CC BY 4.0Reference data
MAM00818m+water+NAD(+)2proton+MAM02137m+NADH(2-)
Catalysed by ALDH3B1 or ALDH3A1 or ALDH3B2 or ALDH1A3
Reaction pageReversibleBalancedEC 1.2.1.5mitochondrial matrix
Human-GEM MAR02192CC BY 4.0Reference data
MAM00818m+water+NADP(3-)2proton+MAM02137m+NADPH(4-)
Catalysed by ALDH3B1 or ALDH3A1 or ALDH3B2
Reaction pageLeft to rightBalancedEC 1.2.1.5mitochondrial matrix
Human-GEM MAR02195CC BY 4.0Reference data
MAM00820m+water+NAD(+)2proton+NADH(2-)+MAM03136m
Catalysed by ALDH3B1 or ALDH3A1 or ALDH3B2 or ALDH1A3
Reaction pageReversibleBalancedEC 1.2.1.5mitochondrial matrix
Human-GEM MAR02196CC BY 4.0Reference data
MAM00820m+water+NADP(3-)2proton+NADPH(4-)+MAM03136m
Catalysed by ALDH3B1 or ALDH3A1 or ALDH3B2
Reaction pageLeft to rightBalancedEC 1.2.1.5mitochondrial matrix
Human-GEM MAR02197CC BY 4.0Reference data
(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate+2proton+NADH(2-)(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al+water+NAD(+)
Catalysed by ALDH3A1 or ALDH9A1
Reaction pageReversibleBalancedEC 1.2.1.3cytosol
Human-GEM MAR03815CC BY 4.0Reference data
(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate+2proton+NADH(2-)(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al+water+NAD(+)
Catalysed by ALDH3A2 or ALDH3A1
Reaction pageReversibleBalancedEC 1.2.1.3endoplasmic reticulum
Human-GEM MAR03821CC BY 4.0Reference data
acetaldehyde+water+NADP(3-)acetate+2proton+NADPH(4-)
Catalysed by ALDH3B1 or ALDH3A1 or ALDH3B2
Reaction pageLeft to rightBalancedEC 1.2.1.5cytosol
Human-GEM MAR04283CC BY 4.0Reference data
water+1-methylimidazole-4-acetaldehyde+NAD(+)2proton+MAM02477c+NADH(2-)
Catalysed by ALDH3B1 or ALDH3A1 or ALDH3B2 or ALDH1A3
Reaction pageLeft to rightBalancedEC 1.2.1.5cytosol
Human-GEM MAR04431CC BY 4.0Reference data
water+NAD(+)+2-phenylacetaldehyde2proton+NADH(2-)+MAM02720c
Catalysed by ALDH3B1 or ALDH3A1 or ALDH3B2
Reaction pageLeft to rightBalancedEC 1.2.1.5, 1.2.1.39cytosol
Human-GEM MAR04683CC BY 4.0Reference data