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Proteins/UNIPROT:P11766
Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage. Also acts as a S-nitroso-glutathione reductase by catalyzing the NADH-dependent reduction of S-nitrosoglutathione, thereby regulating protein S-nitrosylation (By similarity)..
Function from UniProtKB (P11766), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 2 · metabolized by
2 compounds
2 compounds.
0 reported routes2 assembled routes
1 row
295 statements
295 statements · 6 reference databases · Subject: ADH5 · Sources: Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
37 reactions
9 names
Resolves to: ADH5
Reaction pageLeft to rightBalancedEC 1.1.1.1, 1.1.1.2, 1.1.1.21, 1.1.1.72mitochondrial matrix
Human-GEM MAR00458CC BY 4.0Reference data
MAM00339c+NADP(3-)MAM00394c+proton+NADPH(4-)
Catalysed by HSD3B7 or DHRS2 or HTATIP2 or MDH1B or RDH12 or CBR4 or CTBP1 or BDH2 or HSD11B1L or SDR9C7 or SDR16C5 or SDR42E2 and 10 more alternatives
Reaction pageReversibleBalancedEC 1.1.1.-cytosol
Human-GEM MAR01098CC BY 4.0Reference data
MAM00599c+NAD(+)MAM00600c+proton+NADH(2-)
Catalysed by ADHFE1 or ADH6 or ADH1A or ADH7 or ADH5 or ADH4 or ADH1C
Reaction pageReversibleBalancedEC 1.1.1.1cytosol
Human-GEM MAR01129CC BY 4.0Reference data
MAM00599m+NAD(+)MAM00600m+proton+NADH(2-)
Catalysed by ADHFE1 or ADH6 or ADH1A or ADH7 or ADH5 or ADH4 or ADH1C
Reaction pageReversibleBalancedEC 1.1.1.1mitochondrial matrix
Human-GEM MAR01130CC BY 4.0Reference data
MAM00599r+NAD(+)MAM00600r+proton+NADH(2-)
Catalysed by ADH6 or ADH1A or ADH7 or ADH5 or ADH4 or ADH1C
Reaction pageReversibleBalancedEC 1.1.1.1endoplasmic reticulum
Human-GEM MAR01131CC BY 4.0Reference data
MAM00596x+NAD(+)MAM00601x+proton+NADH(2-)
Catalysed by ADHFE1 or ADH6 or ADH1A or ADH7 or ADH5 or ADH4 or ADH1C
Reaction pageLeft to rightBalancedEC 1.1.1.1peroxisome
Human-GEM MAR01288CC BY 4.0Reference data
MAM00756c+proton+NADH(2-)MAM01093c+NAD(+)
Catalysed by ADHFE1 or ADH6 or ADH1A or ADH7 or ADH1B or ADH5 or ADH4 or ADH1C
Reaction pageReversibleBalancedEC 1.1.1.1cytosol
Human-GEM MAR01684CC BY 4.0Reference data
MAM00747r+proton+NADPH(4-)MAM01087r+NADP(3-)
Catalysed by HSD17B14 or HSD3B7 or DHRS2 or HTATIP2 or RDH10 or MDH1B or RDH12 or CBR4 or CTBP1 or BDH2 or HSD11B1L or SDR9C7 and 12 more alternatives
Reaction pageReversibleBalancedEC 1.1.1.-endoplasmic reticulum
Human-GEM MAR01813CC BY 4.0Reference data
ethanol+NAD(+)acetaldehyde+proton+NADH(2-)
Catalysed by ADH6 or ADH1A or ADH7 or ADH1B or ADH5 or ADH4 or ADH1C
Reaction pageLeft to rightBalancedEC 1.1.1.1, 1.1.1.71cytosol
Human-GEM MAR03905CC BY 4.0Reference data
S-formylglutathione+proton+NADH(2-)MAM02152c+NAD(+)
Catalysed by ADH5
Reaction pageReversibleBalancedEC 1.1.1.284cytosol
Human-GEM MAR03933CC BY 4.0Reference data
methanol+NAD(+)formaldehyde+proton+NADH(2-)
Catalysed by ADHFE1 or ADH6 or ADH1A or ADH7 or ADH1B or ADH5 or ADH4 or ADH1C
Reaction pageLeft to rightBalancedEC 1.1.1.244cytosol
Human-GEM MAR04202CC BY 4.0Reference data