prostaglandin D2

1. prostaglandin J2 hydrolysis

No catalyst recordedcytosolOne of 2 routes

1. transport of prostaglandin D2 (cytosol to extracellular)

Catalysed by SLCO1B1extracellular space, cytosolOne of 2 routes

1. prostaglandin D2(out) + 2 (S)-lactate(in) = prostaglandin D2(in) + 2 (S)-lactate(out)

Catalysed by SLCO2A1inner side of the membrane, outer side of the membraneOne of 2 routes

1. transport of GSH and prostaglandin D2 (cytosol to extracellular)

Catalysed by SLCO2A1extracellular space, cytosolOne of 2 routes

1. aldo-keto reductase (prostaglandin D2)

Catalysed by AKR1C3cytosolOne of 2 routes

1. prostaglandin-D synthase (prostaglandin D2)

Catalysed by HPGDS, PTGDSendoplasmic reticulum

1. 15-dehydro-prostaglandin D2 reduction

No catalyst recordedcytosolOne of 2 routes

1. prostaglandin D2 + NADPH + H(+) = 11beta-prostaglandin F2 + NADP(+)

Catalysed by AKR1C3, AKR1C2

1. transport of prostaglandin D2 (cytosol to extracellular)
2. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

1. transport of prostaglandin D2 (cytosol to extracellular)
2. transport of glycoursodeoxycholate (cytosol to extracellular)

Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosol