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Proteins/UNIPROT:P48637
Catalyzes the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Glutathione (gamma-glutamylcysteinylglycine, GSH) is the most abundant intracellular thiol in living aerobic cells and is required for numerous processes including the protection of cells against oxidative damage, amino acid transport, the detoxification of foreign compounds, the maintenance of protein sulfhydryl groups in a reduced state and acts as a cofactor for a number of enzymes. Participates in ophthalmate biosynthesis in hepatocytes (By similarity)..
Function from UniProtKB (P48637), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
2 rows
113 statements
113 statements · 8 reference databases · Subject: GSS · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
3 reactions
ATP+gamma-L-glutamyl-L-cysteine+glycineADP+CHEBI:16856+proton+phosphate(3-)
Catalysed by GSS
Reaction pageLeft to rightBalancedEC 6.3.2.3cytosol
Human-GEM MAR04326CC BY 4.0Reference data
3 names
Resolves to: GSS
Catalysed by GSS
Reaction pageLeft to rightBalanced
Rhea RHEA:13557CC BY 4.0Reference data
gamma-L-glutamyl-(2S)-2-aminobutanoate+glycine+ATP(4-)ophthalmate+ADP(3-)+hydrogenphosphate+hydron
Catalysed by GSS
Reaction pageLeft to rightBalanced
Rhea RHEA:72075CC BY 4.0Reference data