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Proteins/UNIPROT:P48065
Transporter that mediates cellular uptake of betaine and GABA in a sodium- and chloride-dependent process. May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation. Probably also involved in renal and hepatic osmotic regulation (By similarity)..
Function from UniProtKB (P48065), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 2 · transported by
2 compounds
2 compounds.
0 reported routes2 assembled routes
41 statements
41 statements · 5 reference databases · Subject: SLC6A12 · Sources: Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
9 reactions
4-aminobutanoate+2sodium(1+)4-aminobutanoate+2sodium(1+)
Transported by SLC6A13 or SLC6A12 or SLC6A11 or SLC6A1
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR04691CC BY 4.0Reference data
4 names
Resolves to: SLC6A12
Transported by SLC6A12
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR08889CC BY 4.0Reference data
beta-alanine+2chlorine(.)+3sodium(1+)beta-alanine+2chlorine(.)+3sodium(1+)
Transported by SLC6A12
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR09602CC BY 4.0Reference data
glycine betaine+2chlorine(.)+3sodium(1+)glycine betaine+2chlorine(.)+3sodium(1+)
Transported by SLC6A12
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR09603CC BY 4.0Reference data
4-aminobutanoate+2chlorine(.)+3sodium(1+)4-aminobutanoate+2chlorine(.)+3sodium(1+)
Transported by SLC6A12
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR09604CC BY 4.0Reference data
glycine betaine+chlorine(.)+sodium(1+)glycine betaine+chlorine(.)+sodium(1+)
Transported by SLC6A12
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR09873CC BY 4.0Reference data
4-aminobutanoate+chlorine(.)+sodium(1+)4-aminobutanoate+chlorine(.)+sodium(1+)
Transported by SLC6A12
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR09886CC BY 4.0Reference data
4-aminobutanoate+chloride+3sodium(1+)4-aminobutanoate+chloride+3sodium(1+)
Transported by SLC6A12
Reaction pageLeft to rightBalanced
Rhea RHEA:70731CC BY 4.0Reference data
glycine betaine+2chloride+3sodium(1+)glycine betaine+2chloride+3sodium(1+)
Transported by SLC6A12
Reaction pageLeft to rightBalanced
Rhea RHEA:71175CC BY 4.0Reference data