Compound

3-oxohexadecanoyl-CoA

An acyl-CoA(4−) arising from deprotonation of the phosphate and diphosphate OH groups of 3-oxopalmitoyl-CoA.

Definition from ChEBI (CHEBI:57349), read 2026-09-23. CC BY 4.0.

CHEBI:57349ChEBI

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Structure

2D depiction

No three-dimensional record for this entry.

Class: Organic compound, anion
Formula: C37H60N7O18P3S
Mass: 1015.907 g/mol
Charge: -4
InChIKey: NQMPLXPCRJOSHL-BBECNAHFSA-J
SMILES: CCCCCCCCCCCCCC(=O)CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(=O)([O-])OP(=O)([O-])OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1OP(=O)([O-])[O-]
Look it up: ChEBI By InChIKey

Identity from ChEBI. Not evidence.

What it touches on the way

Mechanistic reach

9 entities

9 entities reached.

0 reported hops9 assembled from the scaffold

What the reference databases state

Statements

14 statements

14 statements · 2 reference databases · Subject: 3-oxohexadecanoyl-CoA · Sources: Human-GEM, Rhea

Order

3-oxohexadecanoyl-CoA is converted to tetradecanoyl-CoACompoundRhea RHEA:18161Inferred only
tetradecanoyl-CoA is converted to 3-oxohexadecanoyl-CoACompoundRhea RHEA:39167Inferred only
3-oxohexadecanoyl-CoA is a substrate of ACAA1ProteinHuman-GEM MAR03081Inferred only
3-oxohexadecanoyl-CoA is a substrate of ACAA1ProteinRhea RHEA:18161Inferred only
3-oxohexadecanoyl-CoA is a substrate of ACAA2ProteinHuman-GEM MAR03125Inferred only
3-oxohexadecanoyl-CoA is a substrate of EHHADHProteinRhea RHEA:31159Inferred only
3-oxohexadecanoyl-CoA is a substrate of HADHProteinRhea RHEA:31159Inferred only
3-oxohexadecanoyl-CoA is a substrate of HADHAProteinHuman-GEM MAR03125Inferred only
3-oxohexadecanoyl-CoA is a substrate of HADHAProteinRhea RHEA:31159Inferred only
3-oxohexadecanoyl-CoA is a substrate of HADHBProteinRhea RHEA:18161Inferred only
3-oxohexadecanoyl-CoA is a substrate of HADHBProteinHuman-GEM MAR03125Inferred only
3-oxohexadecanoyl-CoA is a substrate of HSD17B10ProteinRhea RHEA:31159Inferred only

Show the remaining 2

3-oxohexadecanoyl-CoA is a substrate of MYO5BProteinHuman-GEM MAR03081Inferred only
3-oxohexadecanoyl-CoA is a substrate of SCP2ProteinRhea RHEA:18161Inferred only

Reactions

9 reactions

MAM00175x+NAD(+)3-oxohexadecanoyl-CoA+proton+NADH(2-)
Catalysed by ACAA1 & HSD17B4 & EHHADH
Reaction pageLeft to rightBalancedEC 1.1.1.35, 1.1.1.211peroxisome
Human-GEM MAR03080CC BY 4.0Reference data
3-oxohexadecanoyl-CoA+CHEBI:1146900CHEBI:15351+tetradecanoyl-CoA
Catalysed by ACAA1 & MYO5B
Reaction pageLeft to rightBalancedEC 2.3.1.16peroxisome
Human-GEM MAR03081CC BY 4.0Reference data
MAM00175m+NAD(+)3-oxohexadecanoyl-CoA+proton+NADH(2-)
Catalysed by HADHA & HADH & HSD17B10
Reaction pageLeft to rightBalancedEC 1.1.1.35, 1.1.1.211mitochondrial matrix
Human-GEM MAR03123CC BY 4.0Reference data
3-oxohexadecanoyl-CoA+CHEBI:1146900CHEBI:15351+tetradecanoyl-CoA
Catalysed by HADHA & ACAA2 & HADHB
Reaction pageLeft to rightBalancedEC 2.3.1.16, 1.1.1.211mitochondrial matrix
Human-GEM MAR03125CC BY 4.0Reference data
tetradecanoyl-CoA+acetyl-CoA3-oxohexadecanoyl-CoA+coenzyme A(4-)
Catalysed by ACAA1 or SCP2 or HADHB
Reaction pageRight to leftBalanced
Rhea RHEA:18161CC BY 4.0Reference data
CHEBI:62613+NAD(1-)3-oxohexadecanoyl-CoA+NADH(2-)+hydron
Catalysed by HADHA or EHHADH or HADH or HSD17B10
Reaction pageReversibleBalanced
Rhea RHEA:31159CC BY 4.0Reference data
3-oxohexadecanoyl-CoA+NADPH(4-)+hydronCHEBI:74278+NADP(3-)
Reaction pageDirection not assertedBalanced
Rhea RHEA:39163CC BY 4.0Reference data
tetradecanoyl-CoA+malonyl-CoA+hydron3-oxohexadecanoyl-CoA+carbon dioxide+coenzyme A(4-)
Catalysed by ELOVL6 or ELOVL3
Reaction pageLeft to rightBalanced
Rhea RHEA:39167CC BY 4.0Reference data
CHEBI:74278+NAD(1-)3-oxohexadecanoyl-CoA+NADH(2-)+hydron
Catalysed by HSD17B4
Reaction pageLeft to rightBalanced
Rhea RHEA:40243CC BY 4.0Reference data

Other names

1 name

Resolves to: 3-oxohexadecanoyl-CoA

Systematic name: 3'-phosphonatoadenosine 5'-{3-[(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-{[3-oxo-3-({2-[(3-oxohexadecanoyl)sulfanyl]ethyl}amino)propyl]amino}butyl] diphosphate}