S-formylglutathione

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

391 compounds within 3 steps: 5 in 1, 107 in 2, 279 in 3

One step

formateReach from here →
1. S-formylglutathione + H2O = formate + glutathione + H(+)
Catalysed by ESD
formaldehydeReach from here →
1. alcohol dehydrogenase (formaldehyde)
Catalysed by ADH1C, ADH1A, ADH5, ADH6 and 2 morecytosol
CHEBI:16856Reach from here →
1. S-Formylglutathione hydrolase
Catalysed by ESDcytosolOne of 2 routes
formic acidReach from here →
1. S-Formylglutathione hydrolase
Catalysed by ESDcytosol
glutathioneReach from here →
1. S-formylglutathione + H2O = formate + glutathione + H(+)
Catalysed by ESD

Two steps

2-hydroxybutyric acidReach from here →
1. S-Formylglutathione hydrolase
2. transport of 2-hydroxybutyrate and formate (cytosol to extracellular)
Catalysed by ESD, SLC16A4, SLC16A5, SLC16A7 and 1 morecytosol, extracellular spaceOne of 2 routes
2-phenylpropan-2-olReach from here →
1. S-formylglutathione + H2O = formate + glutathione + H(+)
2. cumene hydroperoxide + 2 glutathione = 2-phenylpropan-2-ol + glutathione disulfide + H2O
Catalysed by ESD, CLIC2, GPX1, and 1 more

GPX2

a hydroxy polyunsaturated fatty acidReach from here →

Catalysed by ESD, GPX1, GPX2, GPX4

tauroursodeoxycholateReach from here →

Catalysed by ESD, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 3 routes

glycoursodeoxycholateReach from here →

Catalysed by ESD, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 3 routes

(15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoateReach from here →

Catalysed by ESD, GPX1, GPX4

(11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoateReach from here →

Catalysed by ESD, PTGES, MGST3, GSTA4 and 18 morecytosolOne of 5 routes

prostaglandin E3Reach from here →

Catalysed by ESD, SLCO2A1cytosol, extracellular spaceOne of 2 routes

prostaglandin A2Reach from here →

Catalysed by ESD, SLCO2A1cytosol, extracellular spaceOne of 2 routes

prostaglandin B1Reach from here →

Catalysed by ESD, SLCO2A1cytosol, extracellular spaceOne of 2 routes

leukotriene F4Reach from here →

Catalysed by ESDcytosol, extracellular spaceOne of 2 routes

prostaglandin A2-S-(R)-glutathioneReach from here →

Catalysed by ESD, GSTA1, GSTM1

prostaglandin A2-S-(S)-glutathioneReach from here →

Catalysed by ESD, GSTP1, GSTM1

prostaglandin J2-S-(R)-glutathioneReach from here →

Catalysed by ESD, GSTA1, GSTP1, GSTM1

prostaglandin J2-S-(S)-glutathioneReach from here →

Catalysed by ESD, GSTP1, GSTM1

2,4-dinitrophenyl-S-glutathioneReach from here →

Catalysed by ESD, PTGES, LANCL1, GSTM4 and 1 more

acetoacetateReach from here →

Catalysed by ESD, SLC16A4, SLC16A5cytosol, extracellular spaceOne of 2 routes

(13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoateReach from here →

Catalysed by ESD, GSTM4, LTC4S

S-methyl glutathioneReach from here →

Catalysed by ESD, MMACHC

S-adenosylglutathioneReach from here →

Catalysed by ESD, MMACHC

acetylcholineReach from here →

Catalysed by ESD, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes

pyruvateReach from here →

Catalysed by ESD, SLC16A4, SLC16A5, SLC16A7 and 2 morecytosol, extracellular spaceOne of 2 routes

all-trans-retinoic acidReach from here →

Catalysed by ESD, SLC16A4, SLC16A5cytosol, extracellular spaceOne of 2 routes

10-formyltetrahydrofolic acidReach from here →

Catalysed by ESD, MTHFD1cytosolOne of 2 routes

CHEBI:15650Reach from here →

Catalysed by ESD, SLCO1B1cytosol, extracellular spaceOne of 2 routes

bromideReach from here →

Catalysed by ESD, MGST3, GSTA4, GSTA1 and 14 morecytosolOne of 2 routes

methanethiolReach from here →

Catalysed by ADH1C, ADH1A, ADH5, ADH6 and 3 morecytosol

a halide anionReach from here →

Catalysed by ESD, GSTT4, GSTA4, GSTZ1 and 20 more

lithocholic acidReach from here →

Catalysed by ESD, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes

bilirubin IXalphaReach from here →

Catalysed by ESD, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes

(R)-3-hydroxybutyric acidReach from here →

Catalysed by ESD, SLC16A4, SLC16A5, SLC16A7 and 1 morecytosol, extracellular spaceOne of 2 routes

taurolithocholateReach from here →

Catalysed by ESD, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes

CHEBI:17208Reach from here →

Catalysed by ESDcytosol

homocysteineReach from here →

Catalysed by ESDcytosol

sulfiteReach from here →

Catalysed by ESD, TSTD1One of 2 routes

L-cysteineReach from here →

Catalysed by ESDcytosol

CHEBI:17724Reach from here →

Catalysed by ADH1C, ADH1A, ADH5, ADH6 and 4 morecytosol

urateReach from here →

Catalysed by ESD, SLC22A13inner side of the membrane, outer side of the membrane

methylarsonous acidReach from here →

Catalysed by ESD, GSTO1, GSTO2

arsenic triglutathioneReach from here →

Catalysed by ESD, AS3MTOne of 3 routes

15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathioneReach from here →

Catalysed by ESD, MGST3

(6R)-10-formyltetrahydrofolateReach from here →

Catalysed by ESD, MTHFD1, MTHFD1L

(5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoateReach from here →

Catalysed by ESD, GPX1, GPX4

(12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoateReach from here →

Catalysed by ESD, GPX1, GPX4

(15S)-hydroxy-(11Z,13E)-eicosadienoateReach from here →

Catalysed by ESD, GPX1, GPX4