Compound
succinyl-CoA
An acyl-CoA oxoanion that is the pentaanion of succinyl-CoA, arising from deprotonation of the phosphate, diphosphate and carboxylic acid OH groups.
Definition from ChEBI (CHEBI:57292), read 2026-09-23. CC BY 4.0.
Structure
No three-dimensional record for this entry.
- Class
- Organic compound, anion
- Formula
- C25H35N7O19P3S
- Mass
- 862.574 g/mol
- Charge
- -5
- InChIKey
- VNOYUJKHFWYWIR-ITIYDSSPSA-I
- SMILES
- CC(C)(COP(=O)([O-])OP(=O)([O-])OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1OP(=O)([O-])[O-])[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CCC(=O)[O-]
- Look it up
- ChEBIBy InChIKey
Identity from ChEBI. Not evidence.
What it touches on the way
Mechanistic reach
14 entities
14 entities reached.
0 reported hops14 assembled from the scaffold
- KAT2AProteinUNIPROT:Q92830substrate ofInferred only114 paths90 endpoints
- CPT1AProteinUNIPROT:P50416substrate ofInferred only28 paths28 endpoints
- ALAS1ProteinUNIPROT:P13196substrate ofInferred only26 paths26 endpoints
- OXCT1ProteinUNIPROT:P55809substrate ofInferred only24 paths12 endpoints
- ACOT8ProteinUNIPROT:O14734substrate ofInferred only16 paths16 endpoints
- SUCLG1ProteinUNIPROT:P53597substrate ofInferred only14 paths7 endpoints
- SUCLG2ProteinUNIPROT:Q96I99substrate ofInferred only12 paths12 endpoints
- ALAS2ProteinUNIPROT:P22557substrate ofInferred only9 paths9 endpoints
- ACOT4ProteinUNIPROT:Q8N9L9substrate ofInferred only9 paths9 endpoints
- NUDT19ProteinUNIPROT:A8MXV4substrate ofInferred only6 paths6 endpoints
- NUDT7ProteinUNIPROT:P0C024substrate ofInferred only6 paths6 endpoints
- SUCLA2ProteinUNIPROT:Q9P2R7substrate ofInferred only5 paths5 endpoints
What the reference databases state
Statements
23 statements
23 statements · 1 reference database · Subject: succinyl-CoA · Sources: Rhea
- (R)-methylmalonyl-CoA is converted to succinyl-CoACompoundRhea RHEA:22888Inferred only
- succinyl-CoA is converted to succinate semialdehydeCompoundRhea RHEA:26450Inferred only
- succinate semialdehyde is converted to succinyl-CoACompoundRhea RHEA:26450Inferred only
- succinyl-CoA is converted to succinyl-4'-phosphopantetheineCompoundRhea RHEA:67472Inferred only
- succinyl-CoA is a substrate of ACOT4ProteinRhea RHEA:11516Inferred only
- succinyl-CoA is a substrate of ACOT8ProteinRhea RHEA:11516Inferred only
- succinyl-CoA is a substrate of ALAS1ProteinRhea RHEA:12921Inferred only
- succinyl-CoA is a substrate of ALAS2ProteinRhea RHEA:12921Inferred only
- succinyl-CoA is a substrate of CPT1AProteinRhea RHEA:16261Inferred only
- succinyl-CoA is a substrate of KAT2AProteinRhea RHEA:16261Inferred only
- succinyl-CoA is a substrate of NUDT19ProteinRhea RHEA:67472Inferred only
- succinyl-CoA is a substrate of NUDT7ProteinRhea RHEA:67472Inferred only
Show the remaining 11
- succinyl-CoA is a substrate of NUDT8ProteinRhea RHEA:67472Inferred only
- succinyl-CoA is a substrate of OXCT1ProteinRhea RHEA:24564Inferred only
- succinyl-CoA is a substrate of OXCT1ProteinRhea RHEA:25480Inferred only
- succinyl-CoA is a substrate of OXCT2ProteinRhea RHEA:24564Inferred only
- succinyl-CoA is a substrate of SUCLA2ProteinRhea RHEA:17661Inferred only
- succinyl-CoA is a substrate of SUCLG1ProteinRhea RHEA:22120Inferred only
- succinyl-CoA is a substrate of SUCLG1ProteinRhea RHEA:17661Inferred only
- succinyl-CoA is a substrate of SUCLG2ProteinRhea RHEA:22120Inferred only
- succinyl-CoA is a substrate of SUGCTProteinRhea RHEA:67900Inferred only
- succinyl-CoA is a substrate of SUGCTProteinRhea RHEA:12284Inferred only
- succinyl-CoA is a substrate of SUGCTProteinRhea RHEA:38283Inferred only
Reactions
43 reactions
succinyl-CoA+watersuccinate(2-)+coenzyme A(4-)+hydron
Reaction pageLeft to rightBalanced
Rhea RHEA:11516CC BY 4.0Reference data
CHEBI:15775+succinyl-CoACHEBI:57348+succinate(2-)
Reaction pageDirection not assertedBalanced
Rhea RHEA:12048CC BY 4.0Reference data
3-hydroxy-3-methylglutarate+succinyl-CoA(3S)-3-hydroxy-3-methylglutaryl-CoA+succinate(2-)
Catalysed by SUGCT
Reaction pageReversibleBalanced
Rhea RHEA:12284CC BY 4.0Reference data
succinyl-CoA+glycine+hydron5-aminolevulinate+carbon dioxide+coenzyme A(4-)
Reaction pageLeft to rightBalanced
Rhea RHEA:12921CC BY 4.0Reference data
succinyl-CoA+L-arginineCHEBI:58241+coenzyme A(4-)+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:15185CC BY 4.0Reference data
N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein]+succinyl-CoAN(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[protein]+coenzyme A(4-)
Catalysed by DLST
Reaction pageRight to leftBalance undeterminable
Rhea RHEA:15213CC BY 4.0Reference data
succinyl-CoA+L-lysyl-[protein]N(6)-succinyl-L-lysyl-[protein]+coenzyme A(4-)+hydron
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:16261CC BY 4.0Reference data
CHEBI:58692+succinyl-CoACHEBI:57253+succinate(2-)
Reaction pageDirection not assertedBalanced
Rhea RHEA:16469CC BY 4.0Reference data
2oxidized [2Fe-2S]-[ferredoxin]+2-oxoglutarate(2-)+coenzyme A(4-)succinyl-CoA+2reduced [2Fe-2S]-[ferredoxin]+carbon dioxide+hydron
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:17297CC BY 4.0Reference data
CHEBI:16845+succinyl-CoA+waterCHEBI:15685+coenzyme A(4-)
Reaction pageDirection not assertedBalanced
Rhea RHEA:17325CC BY 4.0Reference data
succinate(2-)+ATP(4-)+coenzyme A(4-)succinyl-CoA+ADP(3-)+hydrogenphosphate
Reaction pageDirection not assertedBalanced
Rhea RHEA:17661CC BY 4.0Reference data
succinyl-CoA+acetyl-CoACHEBI:57348+coenzyme A(4-)
Reaction pageDirection not assertedBalanced
Rhea RHEA:19481CC BY 4.0Reference data
Other names
8 names
Resolves to: succinyl-CoA
- Also called
- S-(3-carboxy-propionyl)-CoA(5-)S-(3-carboxy-propionyl)-CoA(5−)S-(hydrogen succinyl)CoA(5-)S-(hydrogen succinyl)CoA(5−)succinyl-CoA pentaanionsuccinyl-coenzyme A(5-)succinyl-coenzyme A(5−)
- Systematic name
- 3'-phosphonatoadenosine 5'-{3-[(3R)-4-{[3-({2-[(3-carboxylatopropanoyl)sulfanyl]ethyl}amino)-3-oxopropyl]amino}-3-hydroxy-2,2-dimethyl-4-oxobutyl]diphosphate}