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Proteins/UNIPROT:P49366
Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a critical lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. This is the first step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function..
Function from UniProtKB (P49366), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
188 statements
188 statements · 7 reference databases · Subject: DHPS · Sources: Bgee, gene ontology, Hetionet, Human-GEM, Reactome, Rhea, UniProt
4 reactions
MAM01661c+proton+NADH(2-)NAD(+)+spermidine
Catalysed by DHPS
Reaction pageReversibleBalancedEC 2.5.1.46cytosol
Human-GEM MAR06965CC BY 4.0Reference data
trimethylenediamine+MAM00557cMAM01661c
Catalysed by DHPS
Reaction pageReversibleBalancedEC 2.5.1.46cytosol
Human-GEM MAR06966CC BY 4.0Reference data
2 names
Resolves to: DHPS
trimethylenediamine+MAM01670cCHEBI:18019+spermidine
Catalysed by DHPS
Reaction pageReversibleBalancedEC 2.5.1.46cytosol
Human-GEM MAR06967CC BY 4.0Reference data
[eIF5A protein]-L-lysine+spermidine[eIF5A protein]-deoxyhypusine+propane-1,3-diamine
Catalysed by DHPS
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:33299CC BY 4.0Reference data