Loading the page.
Proteins/UNIPROT:Q9NS82
Associates with SLC3A2/4F2hc to form a functional heterodimeric complex that translocates small neutral L- and D-amino acids across the plasma membrane. Preferentially mediates exchange transport, but can also operate via facilitated diffusion (By similarity). Acts as a major transporter for glycine, L- and D-serine in the central nervous system. At the spinal cord and brainstem regulates glycine metabolism and glycinergic inhibitory neurotransmission by providing for glycine de novo synthesis from L-serine and glycine recycling from astrocytes to glycinergic motor neurons (By similarity). At Schaffer collateral-CA1 synapses mediates D-serine and glycine release that modulates post-synaptic activation of NMDA receptors and excitatory glutamatergic transmission (By similarity). May regulate D-serine release from mesenchymal progenitors located in developing subcutaneous adipose tissue, favoring white adipocyte over thermogenic beige adipocyte lineage commitment (By similarity)..
Function from UniProtKB (Q9NS82), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
73 statements
73 statements · 6 reference databases · Subject: SLC7A10 · Sources: gene ontology, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
32 reactions
3 names
Resolves to: SLC7A10
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05077CC BY 4.0Reference data
L-seryl residueL-seryl residue
Transported by SLC3A2 & SLC7A8 or SLC7A5 or SLC36A1 or SLC7A10 or SLC43A1 or SLC7A7
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05079CC BY 4.0Reference data
Transported by SLC3A2 & SLC7A8 or SLC7A5 or SLC7A10 or SLC43A1 or SLC7A7 or SLC7A3
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05084CC BY 4.0Reference data
Transported by SLC3A2 & SLC7A8 or SLC7A5 or SLC36A1 or SLC7A10 or SLC43A1 or SLC7A7 or SLC7A3
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05091CC BY 4.0Reference data
L-alanine+glycineL-alanine+glycine
Transported by SLC7A5 or SLC7A10 or SLC3A2
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR05458CC BY 4.0Reference data
glycine+L-seryl residueglycine+L-seryl residue
Transported by SLC7A5 or SLC7A10 or SLC3A2
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR05460CC BY 4.0Reference data
glycine+CHEBI:16857glycine+CHEBI:16857
Transported by SLC7A5 or SLC7A10 or SLC3A2
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR05470CC BY 4.0Reference data
L-alanine+L-glutamineL-alanine+L-glutamine
Transported by SLC7A5 or SLC7A10 or SLC3A2
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR05473CC BY 4.0Reference data
L-glutamine+L-seryl residueL-glutamine+L-seryl residue
Transported by SLC7A5 or SLC7A10 or SLC3A2
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR05487CC BY 4.0Reference data
L-cysteine+L-glutamineL-cysteine+L-glutamine
Transported by SLC3A2 & SLC7A10 or SLC3A2 & SLC7A5
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR05492CC BY 4.0Reference data
L-glutamine+CHEBI:16857L-glutamine+CHEBI:16857
Transported by SLC7A5 or SLC7A10 or SLC3A2
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR05497CC BY 4.0Reference data