Compound

hexadecanoyl-CoA

A saturated fatty acyl-CoA(4−) that is palmitoyl-CoA in which the phosphate and diphosphate groups have been deprotonated to give the corresponding tetra-anion.

Definition from ChEBI (CHEBI:57379), read 2026-09-23. CC BY 4.0.

CHEBI:57379ChEBI

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Structure

2D depiction

No three-dimensional record for this entry.

Class: Organic compound, anion
Formula: C37H62N7O17P3S
Mass: 1001.924 g/mol
Charge: -4
InChIKey: MNBKLUUYKPBKDU-BBECNAHFSA-J
SMILES: CCCCCCCCCCCCCCCC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(=O)([O-])OP(=O)([O-])OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1OP(=O)([O-])[O-]
Look it up: ChEBI By InChIKey

Identity from ChEBI. Not evidence.

What it touches on the way

Mechanistic reach

40 entities

40 entities reached.

0 reported hops40 assembled from the scaffold

Show the remaining 28

What the reference databases state

Statements

185 statements

185 statements · 1 reference database · Subject: hexadecanoyl-CoA · Sources: Rhea

Order

hexadecanoyl-CoA is converted to (2E)-hexadecenoyl-CoACompoundRhea RHEA:30747Inferred only
hexadecanoyl-CoA is converted to (2E)-hexadecenoyl-CoACompoundRhea RHEA:40167Inferred only
hexadecanoyl-CoA is converted to (2E)-hexadecenoyl-CoACompoundRhea RHEA:46072Inferred only
(2E)-hexadecenoyl-CoA is converted to hexadecanoyl-CoACompoundRhea RHEA:30747Inferred only
(2E)-hexadecenoyl-CoA is converted to hexadecanoyl-CoACompoundRhea RHEA:36143Inferred only
(2E)-hexadecenoyl-CoA is converted to hexadecanoyl-CoACompoundRhea RHEA:46072Inferred only
hexadecanoyl-CoA is converted to 2-hydroxyhexadecanoyl-CoACompoundRhea RHEA:54596Inferred only
3-oxooctadecanoyl-CoA is converted to hexadecanoyl-CoACompoundRhea RHEA:35279Inferred only
hexadecanoyl-CoA is converted to 3-oxooctadecanoyl-CoACompoundRhea RHEA:35315Inferred only
hexadecanoyl-CoA is converted to 3-oxosphinganineCompoundRhea RHEA:14761Inferred only
hexadecanoyl-CoA is converted to hexadecan-1-olCompoundRhea RHEA:36315Inferred only
hexadecan-1-ol is converted to hexadecanoyl-CoACompoundRhea RHEA:86775Inferred only

Show the remaining 173

hexadecanoyl-CoA is converted to hexadecan-1-olCompoundRhea RHEA:86775Inferred only
hexadecanoyl-CoA is converted to hexadecanalCompoundRhea RHEA:27270Inferred only
hexadecanal is converted to hexadecanoyl-CoACompoundRhea RHEA:19705Inferred only
hexadecanal is converted to hexadecanoyl-CoACompoundRhea RHEA:27270Inferred only
hexadecanoyl-CoA is converted to hexadecanalCompoundRhea RHEA:19705Inferred only
hexadecanoate is converted to hexadecanoyl-CoACompoundRhea RHEA:51716Inferred only
hexadecanoyl-CoA is converted to hexadecanoateCompoundRhea RHEA:16645Inferred only
hexadecanoyl-CoA is converted to hexadecanoateCompoundRhea RHEA:51716Inferred only
hexadecanoate is converted to hexadecanoyl-CoACompoundRhea RHEA:30751Inferred only
hexadecanoyl-CoA is converted to S-hexadecanoyl-4'-phosphopantetheineCompoundRhea RHEA:50032Inferred only
hexadecanoyl-CoA is a substrate of ABHD5ProteinRhea RHEA:37143Inferred only
hexadecanoyl-CoA is a substrate of ACAA2ProteinRhea RHEA:16645Inferred only
hexadecanoyl-CoA is a substrate of ACAD9ProteinRhea RHEA:43448Inferred only
hexadecanoyl-CoA is a substrate of ACADLProteinRhea RHEA:43448Inferred only
hexadecanoyl-CoA is a substrate of ACADMProteinRhea RHEA:43448Inferred only
hexadecanoyl-CoA is a substrate of ACADVLProteinRhea RHEA:43448Inferred only
hexadecanoyl-CoA is a substrate of ACOT1ProteinRhea RHEA:16645Inferred only
hexadecanoyl-CoA is a substrate of ACOT11ProteinRhea RHEA:16645Inferred only
hexadecanoyl-CoA is a substrate of ACOT13ProteinRhea RHEA:16645Inferred only
hexadecanoyl-CoA is a substrate of ACOT2ProteinRhea RHEA:16645Inferred only
hexadecanoyl-CoA is a substrate of ACOT4ProteinRhea RHEA:16645Inferred only
hexadecanoyl-CoA is a substrate of ACOT7ProteinRhea RHEA:16645Inferred only
hexadecanoyl-CoA is a substrate of ACOT8ProteinRhea RHEA:16645Inferred only
hexadecanoyl-CoA is a substrate of ACOT9ProteinRhea RHEA:16645Inferred only
hexadecanoyl-CoA is a substrate of ACOX1ProteinRhea RHEA:40167Inferred only
hexadecanoyl-CoA is a substrate of ACOX2ProteinRhea RHEA:40167Inferred only
hexadecanoyl-CoA is a substrate of ACOX3ProteinRhea RHEA:40167Inferred only
hexadecanoyl-CoA is a substrate of AGPAT1ProteinRhea RHEA:37143Inferred only
hexadecanoyl-CoA is a substrate of AGPAT2ProteinRhea RHEA:35903Inferred only
hexadecanoyl-CoA is a substrate of AGPAT2ProteinRhea RHEA:37143Inferred only
hexadecanoyl-CoA is a substrate of AGPAT3ProteinRhea RHEA:42592Inferred only
hexadecanoyl-CoA is a substrate of AGPAT5ProteinRhea RHEA:42592Inferred only
hexadecanoyl-CoA is a substrate of AWAT1ProteinRhea RHEA:38167Inferred only
hexadecanoyl-CoA is a substrate of AWAT2ProteinRhea RHEA:38071Inferred only
hexadecanoyl-CoA is a substrate of AWAT2ProteinRhea RHEA:55328Inferred only
hexadecanoyl-CoA is a substrate of AWAT2ProteinRhea RHEA:55324Inferred only
hexadecanoyl-CoA is a substrate of AWAT2ProteinRhea RHEA:38163Inferred only
hexadecanoyl-CoA is a substrate of AWAT2ProteinRhea RHEA:38175Inferred only
hexadecanoyl-CoA is a substrate of AWAT2ProteinRhea RHEA:38171Inferred only
hexadecanoyl-CoA is a substrate of AWAT2ProteinRhea RHEA:38167Inferred only
hexadecanoyl-CoA is a substrate of BAATProteinRhea RHEA:16645Inferred only
hexadecanoyl-CoA is a substrate of CERS2ProteinRhea RHEA:36687Inferred only
hexadecanoyl-CoA is a substrate of CERS2ProteinRhea RHEA:36539Inferred only
hexadecanoyl-CoA is a substrate of CERS5ProteinRhea RHEA:36539Inferred only
hexadecanoyl-CoA is a substrate of CERS5ProteinRhea RHEA:61472Inferred only
hexadecanoyl-CoA is a substrate of CERS5ProteinRhea RHEA:63888Inferred only
hexadecanoyl-CoA is a substrate of CERS5ProteinRhea RHEA:36687Inferred only
hexadecanoyl-CoA is a substrate of CERS5ProteinRhea RHEA:43040Inferred only
hexadecanoyl-CoA is a substrate of CERS5ProteinRhea RHEA:64008Inferred only
hexadecanoyl-CoA is a substrate of CERS6ProteinRhea RHEA:63888Inferred only
hexadecanoyl-CoA is a substrate of CERS6ProteinRhea RHEA:36687Inferred only
hexadecanoyl-CoA is a substrate of CERS6ProteinRhea RHEA:61472Inferred only
hexadecanoyl-CoA is a substrate of CERS6ProteinRhea RHEA:43040Inferred only
hexadecanoyl-CoA is a substrate of CERS6ProteinRhea RHEA:36539Inferred only
hexadecanoyl-CoA is a substrate of CERS6ProteinRhea RHEA:64008Inferred only
hexadecanoyl-CoA is a substrate of CPT1AProteinRhea RHEA:12661Inferred only
hexadecanoyl-CoA is a substrate of CPT1BProteinRhea RHEA:12661Inferred only
hexadecanoyl-CoA is a substrate of CPT2ProteinRhea RHEA:12661Inferred only
hexadecanoyl-CoA is a substrate of DGAT1ProteinRhea RHEA:38211Inferred only
hexadecanoyl-CoA is a substrate of DGAT1ProteinRhea RHEA:55296Inferred only
hexadecanoyl-CoA is a substrate of DGAT1ProteinRhea RHEA:38163Inferred only
hexadecanoyl-CoA is a substrate of DGAT1ProteinRhea RHEA:38071Inferred only
hexadecanoyl-CoA is a substrate of DGAT1ProteinRhea RHEA:38171Inferred only
hexadecanoyl-CoA is a substrate of DGAT1ProteinRhea RHEA:38175Inferred only
hexadecanoyl-CoA is a substrate of DGAT1ProteinRhea RHEA:38167Inferred only
hexadecanoyl-CoA is a substrate of DGAT2ProteinRhea RHEA:38163Inferred only
hexadecanoyl-CoA is a substrate of DGAT2ProteinRhea RHEA:38175Inferred only
hexadecanoyl-CoA is a substrate of DGAT2ProteinRhea RHEA:38071Inferred only
hexadecanoyl-CoA is a substrate of ELOVL3ProteinRhea RHEA:35315Inferred only
hexadecanoyl-CoA is a substrate of ELOVL6ProteinRhea RHEA:35315Inferred only
hexadecanoyl-CoA is a substrate of ELOVL7ProteinRhea RHEA:35315Inferred only
hexadecanoyl-CoA is a substrate of FADS2ProteinRhea RHEA:37023Inferred only
hexadecanoyl-CoA is a substrate of FAR1ProteinRhea RHEA:36315Inferred only
hexadecanoyl-CoA is a substrate of FAR2ProteinRhea RHEA:36315Inferred only
hexadecanoyl-CoA is a substrate of FITM2ProteinRhea RHEA:50032Inferred only
hexadecanoyl-CoA is a substrate of GLULProteinRhea RHEA:36683Inferred only
hexadecanoyl-CoA is a substrate of GLYATL3ProteinRhea RHEA:58536Inferred only
hexadecanoyl-CoA is a substrate of GNPATProteinRhea RHEA:40715Inferred only
hexadecanoyl-CoA is a substrate of GPAMProteinRhea RHEA:35723Inferred only
hexadecanoyl-CoA is a substrate of GPAT3ProteinRhea RHEA:37143Inferred only
hexadecanoyl-CoA is a substrate of GPAT3ProteinRhea RHEA:35723Inferred only
hexadecanoyl-CoA is a substrate of GPAT4ProteinRhea RHEA:35723Inferred only
hexadecanoyl-CoA is a substrate of HADHAProteinRhea RHEA:43680Inferred only
hexadecanoyl-CoA is a substrate of HHATProteinRhea RHEA:59528Inferred only
hexadecanoyl-CoA is a substrate of HHATProteinRhea RHEA:59580Inferred only
hexadecanoyl-CoA is a substrate of LCLAT1ProteinRhea RHEA:35871Inferred only
hexadecanoyl-CoA is a substrate of LCLAT1ProteinRhea RHEA:37691Inferred only
hexadecanoyl-CoA is a substrate of LCLAT1ProteinRhea RHEA:37143Inferred only
hexadecanoyl-CoA is a substrate of LCLAT1ProteinRhea RHEA:35851Inferred only
hexadecanoyl-CoA is a substrate of LCLAT1ProteinRhea RHEA:38631Inferred only
hexadecanoyl-CoA is a substrate of LPCAT1ProteinRhea RHEA:33315Inferred only
hexadecanoyl-CoA is a substrate of LPCAT1ProteinRhea RHEA:37807Inferred only
hexadecanoyl-CoA is a substrate of LPCAT1ProteinRhea RHEA:37803Inferred only
hexadecanoyl-CoA is a substrate of LPCAT1ProteinRhea RHEA:35983Inferred only
hexadecanoyl-CoA is a substrate of LPCAT1ProteinRhea RHEA:37843Inferred only
hexadecanoyl-CoA is a substrate of LPCAT1ProteinRhea RHEA:37839Inferred only
hexadecanoyl-CoA is a substrate of LPCAT1ProteinRhea RHEA:37819Inferred only
hexadecanoyl-CoA is a substrate of LPCAT1ProteinRhea RHEA:37811Inferred only
hexadecanoyl-CoA is a substrate of LPCAT1ProteinRhea RHEA:35851Inferred only
hexadecanoyl-CoA is a substrate of LPCAT1ProteinRhea RHEA:37383Inferred only
hexadecanoyl-CoA is a substrate of LPCAT1ProteinRhea RHEA:37511Inferred only
hexadecanoyl-CoA is a substrate of LPCAT1ProteinRhea RHEA:37655Inferred only
hexadecanoyl-CoA is a substrate of LPCAT1ProteinRhea RHEA:37527Inferred only
hexadecanoyl-CoA is a substrate of LPCAT2ProteinRhea RHEA:37143Inferred only
hexadecanoyl-CoA is a substrate of LPCAT3ProteinRhea RHEA:37527Inferred only
hexadecanoyl-CoA is a substrate of LPCAT3ProteinRhea RHEA:35983Inferred only
hexadecanoyl-CoA is a substrate of LPCAT3ProteinRhea RHEA:37383Inferred only
hexadecanoyl-CoA is a substrate of LPCAT3ProteinRhea RHEA:37511Inferred only
hexadecanoyl-CoA is a substrate of LPCAT3ProteinRhea RHEA:37655Inferred only
hexadecanoyl-CoA is a substrate of LPCAT4ProteinRhea RHEA:37803Inferred only
hexadecanoyl-CoA is a substrate of LPCAT4ProteinRhea RHEA:37755Inferred only
hexadecanoyl-CoA is a substrate of LPCAT4ProteinRhea RHEA:37767Inferred only
hexadecanoyl-CoA is a substrate of LPGAT1ProteinRhea RHEA:74811Inferred only
hexadecanoyl-CoA is a substrate of LPGAT1ProteinRhea RHEA:65100Inferred only
hexadecanoyl-CoA is a substrate of LPGAT1ProteinRhea RHEA:65096Inferred only
hexadecanoyl-CoA is a substrate of LPGAT1ProteinRhea RHEA:70595Inferred only
hexadecanoyl-CoA is a substrate of LPGAT1ProteinRhea RHEA:35851Inferred only
hexadecanoyl-CoA is a substrate of LPGAT1ProteinRhea RHEA:35855Inferred only
hexadecanoyl-CoA is a substrate of LPGAT1ProteinRhea RHEA:35863Inferred only
hexadecanoyl-CoA is a substrate of LPGAT1ProteinRhea RHEA:35859Inferred only
hexadecanoyl-CoA is a substrate of LPGAT1ProteinRhea RHEA:70591Inferred only
hexadecanoyl-CoA is a substrate of LPGAT1ProteinRhea RHEA:74815Inferred only
hexadecanoyl-CoA is a substrate of MBLAC2ProteinRhea RHEA:16645Inferred only
hexadecanoyl-CoA is a substrate of MBOAT1ProteinRhea RHEA:65128Inferred only
hexadecanoyl-CoA is a substrate of MBOAT2ProteinRhea RHEA:37415Inferred only
hexadecanoyl-CoA is a substrate of MOGAT1ProteinRhea RHEA:77283Inferred only
hexadecanoyl-CoA is a substrate of MOGAT2ProteinRhea RHEA:77283Inferred only
hexadecanoyl-CoA is a substrate of MOGAT3ProteinRhea RHEA:38071Inferred only
hexadecanoyl-CoA is a substrate of MOGAT3ProteinRhea RHEA:38175Inferred only
hexadecanoyl-CoA is a substrate of MOGAT3ProteinRhea RHEA:38299Inferred only
hexadecanoyl-CoA is a substrate of NUDT19ProteinRhea RHEA:50032Inferred only
hexadecanoyl-CoA is a substrate of OLAHProteinRhea RHEA:16645Inferred only
hexadecanoyl-CoA is a substrate of PHYHProteinRhea RHEA:54596Inferred only
hexadecanoyl-CoA is a substrate of PIGWProteinRhea RHEA:83759Inferred only
hexadecanoyl-CoA is a substrate of PLA2G6ProteinRhea RHEA:16645Inferred only
hexadecanoyl-CoA is a substrate of PNPLA3ProteinRhea RHEA:37143Inferred only
hexadecanoyl-CoA is a substrate of PNPLA4ProteinRhea RHEA:38175Inferred only
hexadecanoyl-CoA is a substrate of PPT1ProteinRhea RHEA:16645Inferred only
hexadecanoyl-CoA is a substrate of PPT2ProteinRhea RHEA:16645Inferred only
hexadecanoyl-CoA is a substrate of PRDX6ProteinRhea RHEA:35983Inferred only
hexadecanoyl-CoA is a substrate of SCDProteinRhea RHEA:36931Inferred only
hexadecanoyl-CoA is a substrate of SCD5ProteinRhea RHEA:36931Inferred only
hexadecanoyl-CoA is a substrate of SOAT1ProteinRhea RHEA:42792Inferred only
hexadecanoyl-CoA is a substrate of SPTLC1ProteinRhea RHEA:14761Inferred only
hexadecanoyl-CoA is a substrate of SPTLC2ProteinRhea RHEA:14761Inferred only
hexadecanoyl-CoA is a substrate of SPTLC3ProteinRhea RHEA:14761Inferred only
hexadecanoyl-CoA is a substrate of THEM4ProteinRhea RHEA:16645Inferred only
hexadecanoyl-CoA is a substrate of THEM5ProteinRhea RHEA:16645Inferred only
hexadecanoyl-CoA is a substrate of TLCD3BProteinRhea RHEA:36687Inferred only
hexadecanoyl-CoA is a substrate of ZDHHC1ProteinRhea RHEA:36683Inferred only
hexadecanoyl-CoA is a substrate of ZDHHC11ProteinRhea RHEA:36683Inferred only
hexadecanoyl-CoA is a substrate of ZDHHC11BProteinRhea RHEA:36683Inferred only
hexadecanoyl-CoA is a substrate of ZDHHC12ProteinRhea RHEA:36683Inferred only
hexadecanoyl-CoA is a substrate of ZDHHC13ProteinRhea RHEA:36683Inferred only
hexadecanoyl-CoA is a substrate of ZDHHC14ProteinRhea RHEA:36683Inferred only
hexadecanoyl-CoA is a substrate of ZDHHC15ProteinRhea RHEA:36683Inferred only
hexadecanoyl-CoA is a substrate of ZDHHC16ProteinRhea RHEA:36683Inferred only
hexadecanoyl-CoA is a substrate of ZDHHC17ProteinRhea RHEA:36683Inferred only
hexadecanoyl-CoA is a substrate of ZDHHC18ProteinRhea RHEA:36683Inferred only
hexadecanoyl-CoA is a substrate of ZDHHC19ProteinRhea RHEA:36683Inferred only
hexadecanoyl-CoA is a substrate of ZDHHC2ProteinRhea RHEA:36683Inferred only
hexadecanoyl-CoA is a substrate of ZDHHC20ProteinRhea RHEA:36683Inferred only
hexadecanoyl-CoA is a substrate of ZDHHC21ProteinRhea RHEA:36683Inferred only
hexadecanoyl-CoA is a substrate of ZDHHC22ProteinRhea RHEA:36683Inferred only
hexadecanoyl-CoA is a substrate of ZDHHC23ProteinRhea RHEA:36683Inferred only
hexadecanoyl-CoA is a substrate of ZDHHC24ProteinRhea RHEA:36683Inferred only
hexadecanoyl-CoA is a substrate of ZDHHC3ProteinRhea RHEA:36683Inferred only
hexadecanoyl-CoA is a substrate of ZDHHC4ProteinRhea RHEA:36683Inferred only
hexadecanoyl-CoA is a substrate of ZDHHC5ProteinRhea RHEA:36683Inferred only
hexadecanoyl-CoA is a substrate of ZDHHC6ProteinRhea RHEA:36683Inferred only
hexadecanoyl-CoA is a substrate of ZDHHC7ProteinRhea RHEA:36683Inferred only
hexadecanoyl-CoA is a substrate of ZDHHC8ProteinRhea RHEA:36683Inferred only
hexadecanoyl-CoA is a substrate of ZDHHC9ProteinRhea RHEA:36683Inferred only

Reactions

119 reactions

(R)-carnitine+hexadecanoyl-CoAO-hexadecanoyl-(R)-carnitine+coenzyme A(4-)
Catalysed by CPT2 or CPT1A or CPT1B
Reaction pageReversibleBalanced
Rhea RHEA:12661CC BY 4.0Reference data
L-seryl residue+hexadecanoyl-CoA+hydron3-oxosphinganine+carbon dioxide+coenzyme A(4-)
Catalysed by SPTLC1 or SPTLC2 or SPTLC3
Reaction pageLeft to rightBalanced
Rhea RHEA:14761CC BY 4.0Reference data
CHEBI:16688+hexadecanoyl-CoACHEBI:17551+coenzyme A(4-)
Reaction pageDirection not assertedBalanced
Rhea RHEA:15217CC BY 4.0Reference data
hexadecanoyl-CoA+waterhexadecanoate+coenzyme A(4-)+hydron
Catalysed by ACOT7 or ACOT8 or PLA2G6 or ACAA2 or ACOT2 or PPT1 or BAAT or THEM4 or MBLAC2 or ACOT1 or THEM5 or ACOT4 and 5 more alternatives
Reaction pageLeft to rightBalanced
Rhea RHEA:16645CC BY 4.0Reference data
a di-trans,poly-cis-dolichol+hexadecanoyl-CoAa di-trans,poly-cis-dolichyl hexadecanoate+coenzyme A(4-)
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:16685CC BY 4.0Reference data
hexadecanal+NAD(1-)+coenzyme A(4-)hexadecanoyl-CoA+NADH(2-)+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:19705CC BY 4.0Reference data
hexadecanal+NADP(3-)+coenzyme A(4-)hexadecanoyl-CoA+NADPH(4-)+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:27270CC BY 4.0Reference data
hexadecanoyl-CoA+FAD(3-)+hydron(2E)-hexadecenoyl-CoA+FADH2(2-)
Reaction pageDirection not assertedBalanced
Rhea RHEA:30747CC BY 4.0Reference data
hexadecanoate+ATP(4-)+coenzyme A(4-)hexadecanoyl-CoA+AMP+diphosphate(3-)
Catalysed by SLC27A2 or ACSL4 or ACSL3 or ACSL1 or ACSM1 or ACSBG2 or SLC27A3 or SLC27A4 or ACSBG1 or ACSL6 or ACSL5
Reaction pageLeft to rightBalanced
Rhea RHEA:30751CC BY 4.0Reference data
a 1-acyl-sn-glycero-3-phosphate+hexadecanoyl-CoA1-acyl-2-hexadecanoyl-sn-glycero-3-phosphate+coenzyme A(4-)
Catalysed by LPCAT1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:33315CC BY 4.0Reference data
hexadecanoyl-CoA+glycine+hydronCHEBI:67177+carbon dioxide+coenzyme A(4-)
Reaction pageDirection not assertedBalanced
Rhea RHEA:34107CC BY 4.0Reference data
hexadecanoyl-CoA+L-alanine+hydronCHEBI:68828+carbon dioxide+coenzyme A(4-)
Reaction pageDirection not assertedBalanced
Rhea RHEA:34535CC BY 4.0Reference data

Show the remaining 107

Other names

1 name

Resolves to: hexadecanoyl-CoA

Systematic name: 3'-phosphonatoadenosine 5'-(3-{(3R)-4-[(3-{[2-(hexadecanoylsulfanyl)ethyl]amino}-3-oxopropyl)amino]-3-hydroxy-2,2-dimethyl-4-oxobutyl} diphosphate)