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A reference for what the literature reports. Not medical advice.

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Proteins/UNIPROT:P07327

ADH1A

Protein·UNIPROT:P07327Alcohol dehydrogenase 1A2 compounds

Open in the graph

Alcohol dehydrogenase. Oxidizes primary as well as secondary alcohols. Ethanol is a very poor substrate..

Function from UniProtKB (P07327), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 2 · metabolized by

Inferred

Assembled routes, not reported.

What routes through it

2 compounds

2 compounds.

0 reported routes2 assembled routes

all-trans-retinolCompoundCHEBI:17336Inferred only34 paths17 endpoints
ethanolCompound

What the reference databases state

Statements

43 statements

43 statements · 8 reference databases · Subject: ADH1A · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways

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ADH1A is expressed in colonAnatomyHuman Protein Atlas ENSG00000187758Inferred only
ADH1A is expressed in duodenumAnatomyHuman Protein Atlas ENSG00000187758Inferred only
ADH1A is expressed in liverAnatomyBgee ENSG00000187758Inferred only
ADH1A is expressed in liverAnatomyHuman Protein Atlas ENSG00000187758Inferred only
ADH1A is expressed in rectumAnatomyHuman Protein Atlas ENSG00000187758Inferred only
ADH1A is expressed in right lobe of liverAnatomyBgee ENSG00000187758Inferred only
ADH1A is expressed in Small intestineAnatomyHuman Protein Atlas ENSG00000187758Inferred only
ADH1A is expressed in vermiform appendixAnatomyHuman Protein Atlas ENSG00000187758Inferred only
ADH1A interacts with CSNK2A2ProteinHetionet hetionet:interacts:124-1459Inferred only
ADH1A interacts with HADHProteinHetionet hetionet:interacts:124-3033Inferred only
(5-hydroxyindol-3-yl)acetaldehyde is metabolised by ADH1ACompoundHuman-GEM MAR04561Inferred only
(R)-lactaldehyde is metabolised by ADH1ACompoundHuman-GEM MAR08502Inferred only

Show the remaining 31

(R)-S-lactoylglutathione is metabolised by ADH1ACompoundHuman-GEM MAR08502Inferred only
1-propanol is metabolised by ADH1ACompoundRhea RHEA:50704Inferred only
all-trans-retinol is metabolised by ADH1ACompoundHuman-GEM MAR06631Inferred only
all-trans-retinol is metabolised by ADH1ACompoundHuman-GEM MAR06633Inferred only
an aldehyde is metabolised by ADH1ACompoundRhea RHEA:10736Inferred only
butanal is metabolised by ADH1ACompoundRhea RHEA:33199Inferred only
CHEBI:16856 is metabolised by ADH1ACompoundHuman-GEM MAR08530Inferred only
CHEBI:16856 is metabolised by ADH1ACompoundHuman-GEM MAR08502Inferred only
ethanol is metabolised by ADH1ACompoundHuman-GEM MAR03905Inferred only
formaldehyde is metabolised by ADH1ACompoundHuman-GEM MAR08530Inferred only
methanol is metabolised by ADH1ACompoundHuman-GEM MAR04202Inferred only
propanal is metabolised by ADH1ACompoundRhea RHEA:50704Inferred only
propane-1,2-diol is metabolised by ADH1ACompoundHuman-GEM MAR08507Inferred only
propane-1,2-diol is metabolised by ADH1ACompoundHuman-GEM MAR08508Inferred only
S-formylglutathione is metabolised by ADH1ACompoundHuman-GEM MAR08530Inferred only
ADH1A participates in Abacavir ADMEPathwayReactome R-HSA-2161522Inferred only
ADH1A participates in Abacavir metabolismPathwayReactome R-HSA-2161541Inferred only
ADH1A participates in Biological oxidationsPathwayReactome R-HSA-211859Inferred only
ADH1A participates in Drug ADMEPathwayReactome R-HSA-9748784Inferred only
ADH1A participates in Ethanol effects on histone modificationsPathwayWikiPathways WP3996Inferred only
ADH1A participates in Ethanol oxidationPathwayReactome R-HSA-71384Inferred only
ADH1A participates in Fatty acid omega oxidationPathwayWikiPathways WP206Inferred only
ADH1A participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
ADH1A participates in Phase I - Functionalization of compoundsPathwayReactome R-HSA-211945Inferred only
ADH1A participates in RA biosynthesis pathwayPathwayReactome R-HSA-5365859Inferred only
ADH1A participates in Retinol metabolismPathwayWikiPathways WP5188Inferred only
ADH1A participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
ADH1A participates in Signaling by Nuclear ReceptorsPathwayReactome R-HSA-9006931Inferred only
ADH1A participates in Signaling by Retinoic AcidPathwayReactome R-HSA-5362517Inferred only
ADH1A participates in Vitamin A and carotenoid metabolismPathwayWikiPathways WP716Inferred only
ADH1A requires the cofactor Zn(2+)CompoundUniProt P07327Inferred only

Reactions

22 reactions

MAM01981c+proton+NADPH(4-)MAM01983c+NADP(3-)
Catalysed by AKR1B1 or AKR1A1 or ADH6 or ADH1A or ADH1B or ADH5 or AKR1B10 or ADH4 or ADH1C
Reaction pageReversibleBalancedEC 1.1.1.1, 1.1.1.2, 1.1.1.21, 1.1.1.72cytosol
Human-GEM MAR00453CC BY 4.0Reference data

Other names

2 names

Resolves to: ADH1A

Also called: ADH1Alcohol dehydrogenase subunit alpha

← Every protein Find it in the graph →

·CHEBI:16236

Inferred only17 paths17 endpoints

MAM01983m

→

MAM01981m

Catalysed by AKR1B1 or AKR1A1 or ADH6 or ADH1A or ADH5 or AKR1B10 or ADH4 or ADH1C

Reaction pageLeft to rightBalancedEC 1.1.1.1, 1.1.1.2, 1.1.1.21, 1.1.1.72mitochondrial matrix

Human-GEM MAR00458CC BY 4.0Reference data

MAM00599c+NAD(+)MAM00600c+proton+NADH(2-)

Catalysed by ADHFE1 or ADH6 or ADH1A or ADH7 or ADH5 or ADH4 or ADH1C

Reaction pageReversibleBalancedEC 1.1.1.1cytosol

Human-GEM MAR01129CC BY 4.0Reference data

MAM00599m+NAD(+)MAM00600m+proton+NADH(2-)

Catalysed by ADHFE1 or ADH6 or ADH1A or ADH7 or ADH5 or ADH4 or ADH1C

Reaction pageReversibleBalancedEC 1.1.1.1mitochondrial matrix

Human-GEM MAR01130CC BY 4.0Reference data

MAM00599r+NAD(+)MAM00600r+proton+NADH(2-)

Catalysed by ADH6 or ADH1A or ADH7 or ADH5 or ADH4 or ADH1C

Reaction pageReversibleBalancedEC 1.1.1.1endoplasmic reticulum

Human-GEM MAR01131CC BY 4.0Reference data

MAM00596x+NAD(+)MAM00601x+proton+NADH(2-)

Catalysed by ADHFE1 or ADH6 or ADH1A or ADH7 or ADH5 or ADH4 or ADH1C

Reaction pageLeft to rightBalancedEC 1.1.1.1peroxisome

Human-GEM MAR01288CC BY 4.0Reference data

MAM00756c+proton+NADH(2-)MAM01093c+NAD(+)

Catalysed by ADHFE1 or ADH6 or ADH1A or ADH7 or ADH1B or ADH5 or ADH4 or ADH1C

Reaction pageReversibleBalancedEC 1.1.1.1cytosol

Human-GEM MAR01684CC BY 4.0Reference data

ethanol+NAD(+)acetaldehyde+proton+NADH(2-)

Catalysed by ADH6 or ADH1A or ADH7 or ADH1B or ADH5 or ADH4 or ADH1C

Reaction pageLeft to rightBalancedEC 1.1.1.1, 1.1.1.71cytosol

Human-GEM MAR03905CC BY 4.0Reference data

methanol+NAD(+)formaldehyde+proton+NADH(2-)

Catalysed by ADHFE1 or ADH6 or ADH1A or ADH7 or ADH1B or ADH5 or ADH4 or ADH1C

Reaction pageLeft to rightBalancedEC 1.1.1.244cytosol

Human-GEM MAR04202CC BY 4.0Reference data

(5-hydroxyindol-3-yl)acetaldehyde+proton+NADPH(4-)MAM01110c+NADP(3-)

Catalysed by ADHFE1 or ADH6 or ADH1A or ADH7 or ADH1B or ADH5 or ADH4 or ADH1C

Reaction pageReversibleBalancedEC 1.1.1.1cytosol

Human-GEM MAR04561CC BY 4.0Reference data

NAD(+)+all-trans-retinolproton+NADH(2-)+all-trans-retinal

Catalysed by HSD17B6 or RDH5 or SDR16C5 or ADH6 or ADH1A or ADH7 or ADH1B or ADH5 or ADH4 or ADH1C

Reaction pageLeft to rightBalancedEC 1.1.1.1, 1.1.1.105cytosol

Human-GEM MAR06631CC BY 4.0Reference data

NAD(+)+all-trans-retinolproton+NADH(2-)+all-trans-retinal

Catalysed by HSD17B6 or RDH5 or SDR16C5 or ADH6 or ADH1A or ADH7 or ADH1B or ADH5 or ADH4 or ADH1C

Reaction pageLeft to rightBalancedEC 1.1.1.1, 1.1.1.105endoplasmic reticulum

Human-GEM MAR06633CC BY 4.0Reference data

Show the remaining 10