Loading the page.
Proteins/UNIPROT:P13196
Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products..
Function from UniProtKB (P13196), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
347 statements
347 statements · 8 reference databases · Subject: ALAS1 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways · Rows fetched: 300
4 reactions
MAM00630m+CHEBI:1146900glycine+CHEBI:15380
Reaction pageReversibleBalancedEC 2.3.1.37mitochondrial matrix
Human-GEM MAR03939CC BY 4.0Reference data
MAM00630m+proton5-aminolevulinic acid+carbon dioxide
6 names
Resolves to: ALAS1
Human-GEM MAR04657CC BY 4.0Reference data
glycine+proton+CHEBI:153805-aminolevulinic acid+carbon dioxide+CHEBI:1146900
Catalysed by ALAS1 or ALAS2 or CPNE7
Reaction pageLeft to rightBalancedEC 2.3.1.37mitochondrial matrix
Human-GEM MAR04742CC BY 4.0Reference data
succinyl-CoA+glycine+hydron5-aminolevulinate+carbon dioxide+coenzyme A(4-)
Reaction pageLeft to rightBalanced
Rhea RHEA:12921CC BY 4.0Reference data