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Proteins/UNIPROT:Q8TDN7
Endoplasmic reticulum ceramidase that catalyzes the hydrolysis of ceramides into sphingosine and free fatty acids at alkaline pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. Exhibits a strong substrate specificity towards the natural stereoisomer of ceramides with D-erythro-sphingosine as a backbone and has a higher activity towards very long-chain unsaturated fatty acids like the C24:1-ceramide. May also hydrolyze dihydroceramides to produce dihydrosphingosine. ACER1 is a skin-specific ceramidase that regulates the levels of ceramides, sphingosine and sphingosine-1-phosphate in the epidermis, mediates the calcium-induced differentiation of epidermal keratinocytes and more generally plays an important role in skin homeostasis..
Function from UniProtKB (Q8TDN7), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
22 statements
22 statements · 6 reference databases · Subject: ACER1 · Sources: Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
8 reactions
water+an N-acyl-(4R)-4-hydroxysphinganine(4R)-hydroxysphinganine+fatty acid
Catalysed by ACER3 or ASAH1 or ACER1 or ACER2 or ASAH2
Reaction pageLeft to rightBalance undeterminableEC 3.5.1.23cytosol
Human-GEM MAR00716CC BY 4.0Reference data
5 names
Resolves to: ACER1
Reaction pageLeft to rightBalance undeterminableEC 3.5.1.23Golgi apparatus
Human-GEM MAR00733CC BY 4.0Reference data
an N-acylsphinganine+waterCHEBI:16566+fatty acid
Catalysed by ACER3 or ASAH1 or ACER1 or ACER2 or ASAH2
Reaction pageReversibleBalance undeterminableEC 3.5.1.23cytosol
Human-GEM MAR00753CC BY 4.0Reference data
an N-acylsphing-4-enine+watersphing-4-enine+a fatty acid
Catalysed by NAAA or ASAH1 or ACER2 or ACER1 or ASAH2 or ACER3
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:20856CC BY 4.0Reference data
an N-acylsphinganine+watersphinganine+a fatty acid
Catalysed by ACER2 or ACER1 or ACER3
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:33551CC BY 4.0Reference data
N-(15Z-tetracosenoyl)-sphing-4-enine+water(15Z)-tetracosenoate+sphing-4-enine
Catalysed by ACER2 or ACER1 or ASAH2
Reaction pageReversibleBalanced
Rhea RHEA:41267CC BY 4.0Reference data
N-tetracosanoyl-sphing-4-enine+watertetracosanoate+sphing-4-enine
Reaction pageLeft to rightBalanced
Rhea RHEA:41283CC BY 4.0Reference data
N-(9Z-octadecenoyl)-sphing-4-enine+watersphing-4-enine+(9Z)-octadecenoate
Catalysed by ASAH1 or ACER2 or ACER1 or ASAH2 or ACER3
Reaction pageReversibleBalanced
Rhea RHEA:41299CC BY 4.0Reference data