7,8-dihydrofolate

1. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase

Catalysed by DHFR, DHFR2cytosolOne of 3 routes

1. dihydrofolate:NAD+ oxidoreductase

Catalysed by DHFR, DHFR2cytosolOne of 2 routes

1. (6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH + H(+)

Catalysed by DHFR, DHFR2

1. (6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH + H(+)
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine

Catalysed by DHFR, DHFR2, SHMT1, SHMT2One of 2 routes

1. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
2. Formate:tetrahydrofolate ligase (ADP-forming)

Catalysed by DHFR, DHFR2, MTHFD1cytosol

1. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
3. bile acid-CoA: amino acid N-acyltransferase

Catalysed by DHFR, DHFR2, SHMT1, BAATcytosol, peroxisomeOne of 28 routes

1. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
3. N(omega)-methyl-L-arginine + glyoxylate = 5-(3-methylguanidino)-2-oxopentanoate + glycine