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Proteins/UNIPROT:P47895
Catalyzes the NAD-dependent oxidation of aldehyde substrates, such as all-trans-retinal and all-trans-13,14-dihydroretinal, to their corresponding carboxylic acids, all-trans-retinoate and all-trans-13,14-dihydroretinoate, respectively (By similarity). High specificity for all-trans-retinal as substrate, can also accept acetaldehyde as substrate in vitro but with lower affinity. Required for the biosynthesis of normal levels of retinoate in the embryonic ocular and nasal regions; a critical lipid in the embryonic development of the eye and the nasal region (By similarity)..
Function from UniProtKB (P47895), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
77 statements
77 statements · 5 reference databases · Subject: ALDH1A3 · Sources: Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
16 reactions
acetaldehyde+water+NAD(+)acetate+2proton+NADH(2-)
Catalysed by ALDH3B1 or ALDH3A1 or ALDH3B2 or ALDH1A3
Reaction pageLeft to rightBalancedEC 1.2.1.4, 1.2.1.5cytosol
Human-GEM MAR01568CC BY 4.0Reference data
5 names
Resolves to: ALDH1A3
Reaction pageReversibleBalancedEC 1.2.1.5mitochondrial matrix
Human-GEM MAR02188CC BY 4.0Reference data
MAM00818m+water+NAD(+)2proton+MAM02137m+NADH(2-)
Catalysed by ALDH3B1 or ALDH3A1 or ALDH3B2 or ALDH1A3
Reaction pageReversibleBalancedEC 1.2.1.5mitochondrial matrix
Human-GEM MAR02192CC BY 4.0Reference data
MAM00820m+water+NAD(+)2proton+NADH(2-)+MAM03136m
Catalysed by ALDH3B1 or ALDH3A1 or ALDH3B2 or ALDH1A3
Reaction pageReversibleBalancedEC 1.2.1.5mitochondrial matrix
Human-GEM MAR02196CC BY 4.0Reference data
water+1-methylimidazole-4-acetaldehyde+NAD(+)2proton+MAM02477c+NADH(2-)
Catalysed by ALDH3B1 or ALDH3A1 or ALDH3B2 or ALDH1A3
Reaction pageLeft to rightBalancedEC 1.2.1.5cytosol
Human-GEM MAR04431CC BY 4.0Reference data
proton+NADH(2-)+MAM02843cNAD(+)+MAM02841c
Catalysed by ALDH3B1 or ALDH3A1 or ALDH3B2 or ALDH1A3
Reaction pageReversibleBalancedEC 1.2.1.5cytosol
Human-GEM MAR04841CC BY 4.0Reference data
S-adenosyl-L-methionineMAM01266c+CHEBI:16680
Catalysed by ALDH3B1 or ALDH3B2 or ALDH1A3
Reaction pageLeft to rightUnbalancedEC 1.2.1.5cytosol
Human-GEM MAR04842CC BY 4.0Reference data
water+NAD(+)+all-trans-retinal2proton+NADH(2-)+all-trans-retinoic acid
Catalysed by ALDH1A2 or ALDH1A1 or ALDH1A3
Reaction pageLeft to rightBalancedEC 1.2.1.36cytosol
Human-GEM MAR06646CC BY 4.0Reference data
MAM00726c+water+NAD(+)MAM00727c+2proton+NADH(2-)
Catalysed by ALDH3B1 or ALDH3A1 or ALDH3B2 or ALDH1A3
Reaction pageLeft to rightBalancedEC 1.2.1.5cytosol
Human-GEM MAR06753CC BY 4.0Reference data
MAM00818c+water+NAD(+)2proton+MAM02137c+NADH(2-)
Catalysed by ALDH3B1 or ALDH3A1 or ALDH3B2 or ALDH1A3
Reaction pageLeft to rightBalancedEC 1.2.1.5cytosol
Human-GEM MAR06766CC BY 4.0Reference data
MAM01002c+water+NAD(+)MAM01003c+2proton+NADH(2-)
Catalysed by ALDH3B1 or ALDH3A1 or ALDH3B2 or ALDH1A3
Reaction pageLeft to rightBalancedEC 1.2.1.5cytosol
Human-GEM MAR06790CC BY 4.0Reference data
MAM01440c+NAD(+)2proton+NADH(2-)+MAM03041c
Catalysed by ALDH3B1 or ALDH3A1 or ALDH3B2 or ALDH1A3
Reaction pageLeft to rightBalancedEC 1.2.1.5cytosol
Human-GEM MAR07035CC BY 4.0Reference data