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Reference

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succinate semialdehyde

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

4 compounds within 3 steps: 1 in 1, 1 in 2, 2 in 3

Does it reach a compound?

One step

4-hydroxybutanoateReach from here →
1. 4-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + succinate semialdehyde
Catalysed by ADHFE1One of 2 routes

Two steps

(R)-2-hydroxyglutarateReach from here →
1. 4-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + succinate semialdehyde
2. 4-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + succinate semialdehyde
Catalysed by ADHFE1

Three steps

(S)-3-hydroxybutanoateReach from here →
Catalysed by ADHFE1
AH2Reach from here →
Catalysed by ADHFE1, D2HGDH