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A reference for what the literature reports. Not medical advice.

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Proteins/UNIPROT:P20933

AGA

Protein·UNIPROT:P20933N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase

Open in the graph

Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins..

Function from UniProtKB (P20933), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

1 row

aspartylglucosaminuria has a germline basis in AGADiseaseGenCC HGNC:318|MONDO:0008830Inferred only

Statements

43 statements

43 statements · 5 reference databases · Subject: AGA · Sources: Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea

Search this listOrder

AGA covaries with TAS2R13ProteinHetionet hetionet:covaries:175-50838Inferred only
AGA is expressed in adrenal glandAnatomyHuman Protein Atlas ENSG00000038002Inferred only
AGA is expressed in breastAnatomyHuman Protein Atlas ENSG00000038002Inferred only
AGA is expressed in bronchusAnatomyHuman Protein Atlas ENSG00000038002Inferred only
AGA is expressed in cerebellumAnatomyHuman Protein Atlas ENSG00000038002Inferred only
AGA is expressed in colonAnatomyHuman Protein Atlas ENSG00000038002Inferred only
AGA is expressed in duodenumAnatomyHuman Protein Atlas ENSG00000038002Inferred only
AGA is expressed in endometriumAnatomyHuman Protein Atlas ENSG00000038002Inferred only
AGA is expressed in epididymisAnatomyHuman Protein Atlas ENSG00000038002Inferred only
AGA is expressed in fallopian tubeAnatomyHuman Protein Atlas ENSG00000038002Inferred only
AGA is expressed in gallbladderAnatomyHuman Protein Atlas ENSG00000038002Inferred only
AGA is expressed in liverAnatomyHuman Protein Atlas ENSG00000038002Inferred only

Show the remaining 31

AGA is expressed in lungAnatomyHuman Protein Atlas ENSG00000038002Inferred only
AGA is expressed in myocardiumAnatomyHuman Protein Atlas ENSG00000038002Inferred only
AGA is expressed in nasopharynxAnatomyHuman Protein Atlas ENSG00000038002Inferred only
AGA is expressed in ovaryAnatomyHuman Protein Atlas ENSG00000038002Inferred only
AGA is expressed in pancreasAnatomyHuman Protein Atlas ENSG00000038002Inferred only
AGA is expressed in parathyroid glandAnatomyHuman Protein Atlas ENSG00000038002Inferred only
AGA is expressed in placentaAnatomyHuman Protein Atlas ENSG00000038002Inferred only
AGA is expressed in prostate glandAnatomyHuman Protein Atlas ENSG00000038002Inferred only
AGA is expressed in rectumAnatomyHuman Protein Atlas ENSG00000038002Inferred only
AGA is expressed in saliva-secreting glandAnatomyHuman Protein Atlas ENSG00000038002Inferred only
AGA is expressed in seminal vesicleAnatomyHuman Protein Atlas ENSG00000038002Inferred only
AGA is expressed in Small intestineAnatomyHuman Protein Atlas ENSG00000038002Inferred only
AGA is expressed in stomachAnatomyHuman Protein Atlas ENSG00000038002Inferred only
AGA is expressed in testisAnatomyHuman Protein Atlas ENSG00000038002Inferred only
AGA is expressed in thyroid glandAnatomyHuman Protein Atlas ENSG00000038002Inferred only
AGA is expressed in tonsilAnatomyHuman Protein Atlas ENSG00000038002Inferred only
AGA is expressed in uterine cervixAnatomyHuman Protein Atlas ENSG00000038002Inferred only
AGA is expressed in vermiform appendixAnatomyHuman Protein Atlas ENSG00000038002Inferred only
AGA participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
AGA participates in Innate Immune SystemPathwayReactome R-HSA-168249Inferred only
AGA participates in Neutrophil degranulationPathwayReactome R-HSA-6798695Inferred only
CLCN3 decreases the expression of AGAProteinHetionet hetionet:regulates:1182-175Inferred only
DDIT4 increases the expression of AGAProteinHetionet hetionet:regulates:54541-175Inferred only
LIG1 decreases the expression of AGAProteinHetionet hetionet:regulates:3978-175Inferred only
PKD1 decreases the expression of AGAProteinHetionet hetionet:regulates:5310-175Inferred only
RAN decreases the expression of AGAProteinHetionet hetionet:regulates:5901-175Inferred only
SNW1 decreases the expression of AGAProteinHetionet hetionet:regulates:22938-175Inferred only
CHEBI:17261 is a substrate of AGACompoundHuman-GEM MAR09530Inferred only
L-aspartate is a substrate of AGACompoundRhea RHEA:11544Inferred only
N-acetyl-beta-D-glucosaminylamine is a substrate of AGACompoundRhea RHEA:11544Inferred only
N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine is a substrate of AGACompoundRhea RHEA:11544Inferred only

Reactions

5 reactions

water+MAM02237lMAM00198l+MAM02248l
Catalysed by AGA
Reaction pageLeft to rightBalance undeterminableEC 3.5.1.26lysosome
Human-GEM MAR07376CC BY 4.0Reference data
MAM01652l+waterMAM00198l+MAM01651l
Catalysed by AGA
Reaction pageLeft to rightBalance undeterminableEC 3.5.1.26lysosome
Human-GEM MAR07574CC BY 4.0Reference data

Other names

6 names

Resolves to: AGA

Also called: [Cleaved into: Glycosylasparaginase alpha chain; Glycosylasparaginase beta chain]4Aspartylglucosaminidasebeta-N-acetylglucosaminylGlycosylasparaginaseN4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase

← Every protein Find it in the graph →

+MAM02510l

→

MAM00198l

+MAM02509l

Catalysed by AGA

Reaction pageLeft to rightBalance undeterminableEC 3.5.1.26lysosome

Human-GEM MAR07585CC BY 4.0Reference data

water+CHEBI:17261L-aspartate+proton+N-acetyl-beta-D-glucosaminylamine

Catalysed by AGA

Reaction pageLeft to rightBalancedEC 3.5.1.26cytosol

Human-GEM MAR09530CC BY 4.0Reference data

N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine+waterN-acetyl-beta-D-glucosaminylamine+L-aspartate+hydron

Catalysed by AGA

Reaction pageDirection not assertedBalanced

Rhea RHEA:11544CC BY 4.0Reference data