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Proteins/UNIPROT:Q6IB77
Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate numerous substrates to form a variety of N-acylglycines, with a preference for benzoyl-CoA over phenylacetyl-CoA as acyl donors. Thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid..
Function from UniProtKB (Q6IB77), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
61 statements
61 statements · 7 reference databases · Subject: GLYAT · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
13 reactions
CHEBI:1146900+proton+MAM02558marachidonoyl-CoA+glycine
Catalysed by GLYAT or GLYATL2 or GLYATL1
Reaction pageReversibleBalancedEC 2.3.1.13mitochondrial matrix
Human-GEM MAR03743CC BY 4.0Reference data
CHEBI:1146900+proton+MAM02181mglycine+isobutyryl-CoA
Catalysed by
10 names
Resolves to: GLYAT
Reaction pageReversibleBalancedEC 2.3.1.13mitochondrial matrix
Human-GEM MAR03750CC BY 4.0Reference data
CHEBI:1146900+proton+MAM02190mglycine+isovaleryl-CoA
Catalysed by GLYAT or GLYATL2 or GLYATL1
Reaction pageReversibleBalancedEC 2.3.1.13mitochondrial matrix
Human-GEM MAR03771CC BY 4.0Reference data
MAM00825m+CHEBI:1146900+proton3-methylbut-2-enoyl-CoA+glycine
Catalysed by GLYAT
Reaction pageReversibleBalancedEC 2.3.1.13mitochondrial matrix
Human-GEM MAR03772CC BY 4.0Reference data
CHEBI:15477+glycineCHEBI:240943+CHEBI:1146900+proton
Catalysed by GLYAT or GLYATL2 or GLYATL1
Reaction pageReversibleBalancedEC 2.3.1.13mitochondrial matrix
Human-GEM MAR03782CC BY 4.0Reference data
glycine+phenylacetyl-CoACHEBI:1146900+proton+phenylacetylglycine
Catalysed by GLYAT
Reaction pageLeft to rightBalancedEC 2.3.1.13cytosol
Human-GEM MAR08796CC BY 4.0Reference data
glycine+phenylacetyl-CoACHEBI:1146900+proton+phenylacetylglycine
Catalysed by GLYAT
Reaction pageReversibleBalancedEC 2.3.1.13mitochondrial matrix
Human-GEM MAR10459CC BY 4.0Reference data
glycine+propionyl-CoACHEBI:1146900+proton+MAM03886m
Catalysed by GLYAT
Reaction pageReversibleBalancedEC 2.3.1.13mitochondrial matrix
Human-GEM MAR11502CC BY 4.0Reference data
glycine+2-methylcrotonoyl-CoACHEBI:1146900+proton+MAM03997m
Catalysed by GLYAT
Reaction pageReversibleBalancedEC 2.3.1.13mitochondrial matrix
Human-GEM MAR11509CC BY 4.0Reference data
glycine+CHEBI:27540CHEBI:1146900+proton+MAM03660c
Catalysed by GLYAT
Reaction pageLeft to rightBalancedEC 2.3.1.13cytosol
Human-GEM MAR11555CC BY 4.0Reference data
glycine+octanedioyl-CoACHEBI:1146900+proton+MAM03955c
Catalysed by GLYAT
Reaction pageLeft to rightBalancedEC 2.3.1.13cytosol
Human-GEM MAR11562CC BY 4.0Reference data
benzoyl-CoA+glycineN-benzoylglycine+coenzyme A(4-)+hydron
Catalysed by GLYAT
Reaction pageDirection not assertedBalanced
Rhea RHEA:18493CC BY 4.0Reference data