Compound

adenosine 5'-phosphosulfate

5'-Adenylic acid, monoanhydride with sulfuric acid. The initial compound formed by the action of ATP sulfurylase on sulfate ions after sulfate uptake. Synonyms: adenosine sulfatophosphate; APS.

Definition from MeSH (D000250), National Library of Medicine, read 2026-09-23. NLM revises MeSH; this copy may not reflect its current record.

CHEBI:58243ChEBI

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Structure

2D depiction · 3D model shown

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A generated conformer of adenosine 5'-phosphosulfate — one low-energy arrangement PubChem computed, not a measured structure. Hydrogens are not drawn; the formula counts them.

Class: Organic compound, anion
Formula: C10H12N5O10PS
Mass: 425.272 g/mol
Charge: -2
InChIKey: IRLPACMLTUPBCL-KQYNXXCUSA-L
SMILES: Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)([O-])OS(=O)(=O)[O-])[C@@H](O)[C@H]1O
Look it up: ChEBI PubChem By InChIKey

Identity from ChEBI, geometry from PubChem. Not evidence.

What it touches on the way

Mechanistic reach

3 entities

3 entities reached.

0 reported hops3 assembled from the scaffold

What the reference databases state

Statements

12 statements

12 statements · 2 reference databases · Subject: adenosine 5'-phosphosulfate · Sources: Human-GEM, Rhea

Order

sulfate is converted to adenosine 5'-phosphosulfateCompoundHuman-GEM MAR04185Inferred only
sulfate is converted to adenosine 5'-phosphosulfateCompoundRhea RHEA:16529Inferred only
sulfate is converted to adenosine 5'-phosphosulfateCompoundRhea RHEA:17041Inferred only
adenosine 5'-phosphosulfate is converted to sulfateCompoundRhea RHEA:17041Inferred only
adenosine 5'-phosphosulfate is converted to sulfateCompoundRhea RHEA:16529Inferred only
sulfate is converted to adenosine 5'-phosphosulfateCompoundRhea RHEA:18133Inferred only
adenosine 5'-phosphosulfate is a substrate of FHITProteinRhea RHEA:17041Inferred only
adenosine 5'-phosphosulfate is a substrate of FHITProteinRhea RHEA:19197Inferred only
adenosine 5'-phosphosulfate is a substrate of PAPSS1ProteinHuman-GEM MAR04186Inferred only
adenosine 5'-phosphosulfate is a substrate of PAPSS1ProteinRhea RHEA:24152Inferred only
adenosine 5'-phosphosulfate is a substrate of PAPSS2ProteinHuman-GEM MAR04186Inferred only
adenosine 5'-phosphosulfate is a substrate of PAPSS2ProteinRhea RHEA:24152Inferred only

Reactions

13 reactions

ATP+proton+sulfateadenosine 5'-phosphosulfate+diphosphate(3-)
Catalysed by PAPSS1 or PAPSS2
Reaction pageLeft to rightBalancedEC 2.7.7.4cytosol
Human-GEM MAR04185CC BY 4.0Reference data
adenosine 5'-phosphosulfate+ATPADP+proton+3'-phospho-5'-adenylyl sulfate
Catalysed by PAPSS1 or PAPSS2
Reaction pageLeft to rightBalancedEC 2.7.1.25cytosol
Human-GEM MAR04186CC BY 4.0Reference data
water+3'-phospho-5'-adenylyl sulfateadenosine 5'-phosphosulfate+phosphate(3-)
Catalysed by BPNT1
Reaction pageLeft to rightBalancedEC 3.1.3.7cytosol
Human-GEM MAR04187CC BY 4.0Reference data
glutathione disulfide+sulfite+AMP+2hydronadenosine 5'-phosphosulfate+2glutathione
Reaction pageDirection not assertedBalanced
Rhea RHEA:14141CC BY 4.0Reference data
sulfate+ADP(3-)+hydronadenosine 5'-phosphosulfate+hydrogenphosphate
Reaction pageDirection not assertedBalanced
Rhea RHEA:16529CC BY 4.0Reference data
adenosine 5'-phosphosulfate+watersulfate+AMP+2hydron
Catalysed by FHIT
Reaction pageDirection not assertedBalanced
Rhea RHEA:17041CC BY 4.0Reference data
sulfate+ATP(4-)+hydronadenosine 5'-phosphosulfate+diphosphate(3-)
Catalysed by PAPSS1 or PAPSS2
Reaction pageLeft to rightBalanced
Rhea RHEA:18133CC BY 4.0Reference data
adenosine 5'-phosphosulfate+ammoniumadenosine 5'-phosphoramidate+sulfate+2hydron
Catalysed by FHIT
Reaction pageDirection not assertedBalanced
Rhea RHEA:19197CC BY 4.0Reference data
[thioredoxin]-disulfide+sulfite+AMP+2hydronadenosine 5'-phosphosulfate+[thioredoxin]-dithiol
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:21976CC BY 4.0Reference data
adenosine 5'-phosphosulfate+ATP(4-)3'-phosphoadenylyl sulfate+ADP(3-)+hydron
Catalysed by PAPSS1 or PAPSS2
Reaction pageLeft to rightBalanced
Rhea RHEA:24152CC BY 4.0Reference data
sulfite+A+AMP+2hydronadenosine 5'-phosphosulfate+AH2
Reaction pageDirection not assertedBalanced
Rhea RHEA:24240CC BY 4.0Reference data
3'-phosphoadenylyl sulfate+wateradenosine 5'-phosphosulfate+hydrogenphosphate
Catalysed by BPNT1
Reaction pageLeft to rightBalanced
Rhea RHEA:77639CC BY 4.0Reference data

Show the remaining 1

Other names

2 names

Resolves to: adenosine 5'-phosphosulfate

Also called: 5'-adenylyl sulfate dianion
Systematic name: 5'-O-[(sulfonatooxy)phosphinato]adenosine