sulfate

Three steps

• isovaleryl-CoAReach from here →
  1. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. glycine N-acyltransferase (isovalerylglycine)

  Catalysed by SLC25A14, SLC25A30, NAT8L, GLYAT and 2 moreinner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 3 routes

• arachidonoyl-CoAReach from here →
  1. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Arachidonate:CoA ligase (AMP-forming)

  Catalysed by SLC25A14, SLC25A30, NAT8L, SLC27A2 and 7 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 11 routes

• CHEBI:15519Reach from here →
  1. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. propanoyl-CoA C-acyltransferase

  Catalysed by SLC25A14, SLC25A30, NAT8L, ACAA1 and 2 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, peroxisomeOne of 2 routes

• palmitoyl-CoAReach from here →
  1. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Palmitate:CoA ligase (AMP-forming)

  Catalysed by SLC25A14, SLC25A30, NAT8L, SLC27A2 and 7 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 11 routes

• oleoyl-CoAReach from here →
  1. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Transport of octadecenoyl-CoA into Mitochondrial Matrix

  Catalysed by SLC25A14, SLC25A30, NAT8L, CPT1A and 2 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 11 routes

• phenylacetyl-CoAReach from here →
  1. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Phenylacetate:CoA ligase

  Catalysed by SLC25A14, SLC25A30, NAT8Linner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 3 routes

• propionyl-CoAReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. Carnitine Transport by Atb0
  3. Active Transport

  Catalysed by SLC26A6, SLC6A14extracellular space, cytosol, mitochondrial matrixOne of 45 routes

• D-threo-isocitrateReach from here →
  1. transport of malate and sulfate (cytosol to mitochondria)
  2. Citrate Transport, Mitochondrial
  3. citrate = D-threo-isocitrate

  Catalysed by SLC25A10, SLC25A1, ACO1, ACO2mitochondrial matrix, cytosolOne of 3 routes

• CHEBI:15570Reach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. transport of D-alanine and glycine (cytosol to extracellular)

  Catalysed by SLC26A6, SLC6A9, SLC6A14, SLC3A2 and 1 moreextracellular space, cytosolOne of 5 routes

• CHEBI:15611Reach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. S-Adenosyl-L-methionine:glycine N-methyltransferase

  Catalysed by SLC26A6, SLC6A9, SLC6A14, GNMTextracellular space, cytosol

• 15(S)-HPETEReach from here →
  1. thiosulfate(in) + sulfate(out) = thiosulfate(out) + sulfate(in)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. Glutathione: 15-HPETE oxidoreductase

  Catalysed by SLC25A14, SLC25A30, SLC26A1, SLC25A10 and 10 moreinner side of the membrane, outer side of the membrane, cytosol

• 10-formyltetrahydrofolic acidReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. transport of chloride and formate (cytosol to extracellular)
  3. Formate:tetrahydrofolate ligase (ADP-forming)

  Catalysed by SLC26A6, SLC26A4, MTHFD1extracellular space, cytosolOne of 2 routes

• (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterinReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine

  Catalysed by SLC26A6, SLC6A14, PAHextracellular space, cytosolOne of 6 routes

• CHEBI:15650Reach from here →
  1. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  2. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)
  3. transport of leukotriene E4 (cytosol to extracellular)

  Catalysed by STS, SLCO1B1extracellular space, cytosolOne of 4 routes

• CHEBI:15699Reach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. transport of glycine and homoserine (cytosol to extracellular)

  Catalysed by SLC26A6, SLC6A9, SLC6A14, SLC7A5extracellular space, cytosolOne of 52 routes

• trans-aconitateReach from here →
  1. transport of malate and sulfate (cytosol to mitochondria)
  2. Citrate Transport, Mitochondrial
  3. trans-aconitate(in) + citrate(out) = trans-aconitate(out) + citrate(in)

  Catalysed by SLC25A10, SLC25A1mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• betaine aldehydeReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. transport of chloride and choline (cytosol to extracellular)
  3. choline dehydrogenase (choline)

  Catalysed by SLC26A6, SLC5A7, CHDHextracellular space, cytosolOne of 3 routes

• trimethylenediamineReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. transport of chloride and lysine (cytosol to extracellular)
  3. deoxyhypusine synthase (1,3-diaminopropane)

  Catalysed by SLC26A6, SLC6A14, DHPSextracellular space, cytosol

• CHEBI:15727Reach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. transport of chloride and histidine (cytosol to extracellular)
  3. L-histidine:beta-alanine ligase (ADP-forming)

  Catalysed by SLC26A6, SLC6A14, CARNS1extracellular space, cytosolOne of 3 routes

• butanalReach from here →
  1. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  2. dehydroepiandrosterone 3-sulfate(in) + butanoate(out) = dehydroepiandrosterone 3-sulfate(out) + butanoate(in)
  3. butanal + NAD(+) + H2O = butanoate + NADH + 2 H(+)

  Catalysed by STS, SLC22A9, ALDH9A1inner side of the membrane, outer side of the membrane

• CHEBI:15746Reach from here →
  1. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. diamine N-acetyltransferase (N1-acetylspermine)

  Catalysed by SLC25A14, SLC25A30, NAT8L, SAT1 and 1 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 2 routes

• hexadecanoic acidReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. Carnitine Transport by Atb0
  3. Utilized Transport

  Catalysed by SLC26A6, SLC6A14extracellular space, cytosol, endoplasmic reticulumOne of 2 routes

• CHEBI:15765Reach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. Transport of L-Tyrosine by Atb0 Transporter
  3. L-Tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)

  Catalysed by SLC26A6, SLC6A14, THextracellular space, cytosolOne of 5 routes

• alpha-D-glucosamine 6-phosphateReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. Transport of L-Glutamine by Atb0 Transporter
  3. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)

  Catalysed by SLC26A6, SLC6A14, GFPT2, GFPT1extracellular space, cytosol

• beta-nicotinamide D-ribosideReach from here →
  1. transport of fumarate and sulfate (cytosol to mitochondria)
  2. a quinone + succinate = fumarate + a quinol
  3. 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) = beta-nicotinamide D-riboside + a quinol

  Catalysed by SLC25A10, SDHB, NQO2mitochondrial matrix, cytosol

• N-acetyl-beta-D-glucosaminylamineReach from here →
  1. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  2. N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+)
  3. N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+)

  Catalysed by SLC25A14, SLC25A30, AGAinner side of the membrane, outer side of the membrane

• thioredoxin dithiolReach from here →
  1. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  2. L-Aspartate:tRNA(Asp) ligase (AMP-forming)
  3. glycyl-tRNA(gly) phosphorylation

  Catalysed by SLC25A14, SLC25A30, DARS1inner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• ferricytochrome cReach from here →
  1. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
  2. sulfite:ferricytochrome-c oxidoreductase
  3. 13(S)-HPODE to 13-oxy-radical-octadecadienoate conversion

  Catalysed by SLC25A14, SLC25A30, SUOXinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 4 routes

• 5alpha-androstan-3,17-dioneReach from here →
  1. steroid sulfatase (androsterone sulfate)
  2. steroid sulfatase (androsterone sulfate)
  3. androsterone + NAD(+) = 5alpha-androstan-3,17-dione + NADH + H(+)

  Catalysed by STS, HSD17B6, RDH16, RDH5 and 1 morecytosolOne of 2 routes

• methanethiolReach from here →
  1. thiosulfate(in) + sulfate(out) = thiosulfate(out) + sulfate(in)
  2. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  3. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)

  Catalysed by SLC25A14, SLC25A30, SLC26A1, SLC25A10 and 1 moreinner side of the membrane, outer side of the membrane, cytosol

• a halide anionReach from here →
  1. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. RX + glutathione = an S-substituted glutathione + a halide anion + H(+)

  Catalysed by SLC25A14, SLC25A30, TSTD1, GSTT4 and 22 moreinner side of the membrane, outer side of the membrane

• ureaReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. transport of arginine and chloride (cytosol to extracellular)
  3. L-Arginine amidinohydrolase

  Catalysed by SLC26A6, SLC6A14, ARG1extracellular space, cytosolOne of 6 routes

• 2-methyl-3-oxopropanoic acidReach from here →
  1. transport of malate and sulfate (cytosol to mitochondria)
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by SLC25A10, ME2, ME3, AGXT2mitochondrial matrix, cytosol

• succinic semialdehydeReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. transport of 4-aminobutyrate and chloride (cytosol to extracellular)
  3. 4-aminobutanoate:2-oxoglutarate aminotransferase

  Catalysed by SLC26A6, SLC6A12, ABATextracellular space, cytosol, mitochondrial matrix

• 11-cis-retinolReach from here →
  1. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by SLC25A14, SLC25A30, NAT8L, DGAT1 and 4 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosol

• (R)-3-aminoisobutyric acidReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. transport of alanine and chloride (cytosol to extracellular)
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by SLC26A6, SLC6A14, AGXT2extracellular space, cytosol, mitochondrial matrix

• lithocholic acidReach from here →
  1. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  2. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)
  3. transport of lithocholate (cytosol to extracellular)

  Catalysed by STS, SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 2 routes

• (R)-carnitineReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. transport of betaine and chloride (cytosol to extracellular)
  3. glycine betaine(out) + (R)-carnitine(in) = glycine betaine(in) + (R)-carnitine(out)

  Catalysed by SLC26A6, SLC6A12, SLC22A5extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• L-citrullineReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. transport of citrulline and glycine (cytosol to extracellular)

  Catalysed by SLC26A6, SLC6A9, SLC6A14, SLC7A9 and 2 moreextracellular space, cytosolOne of 42 routes

• cis-aconitateReach from here →
  1. transport of malate and sulfate (cytosol to mitochondria)
  2. Citrate Transport, Mitochondrial
  3. cis-aconitate(in) + citrate(out) = cis-aconitate(out) + citrate(in)

  Catalysed by SLC25A10, SLC25A1mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• androst-4-ene-3,17-dioneReach from here →
  1. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  2. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase
  3. 3beta-Hydroxyandrost-5-en-17-one:NAD+ 3-oxidoreductase/delta5-delta-4 isomerase

  Catalysed by STS, HSD3B1, HSD3B2cytosol, endoplasmic reticulum

• 17beta-estradiolReach from here →
  1. estrone 3-sulfate + H2O = estrone + sulfate + H(+)
  2. Estrone 3-sulfate sulfohydrolase
  3. Estradiol-17beta:NADP+ 17-oxidoreductase

  Catalysed by STS, HSD17B6, HSD17B1, HSD17B2 and 4 morecytosolOne of 5 routes

• nitric oxideReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. transport of arginine and chloride (cytosol to extracellular)
  3. L-Arginine, NADPH:Oxygen Oxidoreductase (Nitric-Oxide-Forming)

  Catalysed by SLC26A6, SLC6A14, NOS3, NOS1 and 1 moreextracellular space, cytosolOne of 2 routes

• CHEBI:16523Reach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. transport of D-serine and glycine (cytosol to extracellular)

  Catalysed by SLC26A6, SLC6A9, SLC6A14, SLC3A2 and 1 moreextracellular space, cytosolOne of 4 routes

• 2-phenylacetamideReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. L-phenylalanine:oxygen 2-oxidoreductase (decarboxylating)

  Catalysed by SLC26A6, SLC6A14, EPXextracellular space, cytosol

• CHEBI:16633Reach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. transport of alanine and chloride (cytosol to extracellular)
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by SLC26A6, SLC6A14, SCLYextracellular space, cytosol

• Met-tRNA(Met)Reach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. transport of chloride and methionine (cytosol to extracellular)
  3. L-Methionine:tRNAMet ligase (AMP-forming)

  Catalysed by SLC26A6, SLC6A14, MARS1extracellular space, cytosol

• (S)-lactateReach from here →
  1. transport of malate and sulfate (cytosol to mitochondria)
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)

  Catalysed by SLC25A10, ME2, ME3, LDHA and 4 moremitochondrial matrix, cytosolOne of 6 routes

• CHEBI:16668Reach from here →
  1. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  2. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  3. 3-sulfino-L-alanine carboxy-lyase

  Catalysed by SLC25A14, SLC25A30, SLC25A12, SLC25A13 and 2 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosol

• 4-methylsulfanyl-2-oxobutanoateReach from here →
  1. transport of malate and sulfate (cytosol to mitochondria)
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine

  Catalysed by SLC25A10, CLYBL, AADATmitochondrial matrix, cytosolOne of 2 routes