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propionyl-CoA

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

687 compounds within 3 steps: 5 in 1, 130 in 2, 552 in 3

Does it reach a compound?

One step

(S)-carnitineReach from here →
1. Active Transport
No catalyst recordedmitochondrial matrix, cytosolOne of 2 routes
CHEBI:1146900Reach from here →
1. Propanoyl-CoA hydrolase
Catalysed by ACOT7cytosolOne of 13 routes
propionic acidReach from here →
1. Propanoyl-CoA hydrolase
Catalysed by ACOT7cytosolOne of 3 routes
(S)-methylmalonyl-CoAReach from here →
1. propanoyl-CoA:carbon-dioxide ligase (ADP-forming)
Catalysed by PCCA, PCCBmitochondrial matrix
acryloyl-CoAReach from here →
1. medium-chain acyl-CoA dehydrogenase (propanoyl-CoA)
Catalysed by ACADS, ACADSBmitochondrial matrix

Two steps

2-hydroxybutyric acidReach from here →
1. Propanoyl-CoA hydrolase
2. transport of 2-hydroxybutyrate and propanoate (cytosol to extracellular)
Catalysed by ACOT7, SLC16A4, SLC16A5, SLC16A7 and 1 morecytosol, extracellular spaceOne of 2 routes
(5E)-tetradecenoyl-(R)-carnitineReach from here →
1. Active Transport
2. carnitine O-palmitoyltransferase ((9E)-tetradecenoyl-CoA)
Catalysed by CPT1A, CPT1C, CPT1Bmitochondrial matrix, cytosol

Page 1 of 14

One of 7 routes

acetoacetateReach from here →

Propanoyl-CoA hydrolase
transport of acetoacetate and propanoate (cytosol to extracellular)

Catalysed by ACOT7, SLC16A4, SLC16A5, SLC16A7 and 2 morecytosol, extracellular spaceOne of 2 routes

(7Z)-octadecenoyl-CoAReach from here →

Propanoyl-CoA hydrolase
carnitine O-palmitoyltransferase ((7Z)-octadecenoyl-CoA)

Catalysed by ACOT7, CPT1A, CPT1C, CPT1BcytosolOne of 3 routes

CHEBI:15345Reach from here →

Propanoyl-CoA hydrolase
Acetoacetate:CoA ligase (AMP-forming)

Catalysed by ACOT7, AACScytosolOne of 2 routes

cholineReach from here →

Propanoyl-CoA hydrolase
Acetyl-CoA:choline O-acetyltransferase

Catalysed by ACOT7, CHATcytosol, nucleus

pyruvateReach from here →

Propanoyl-CoA hydrolase
transport of propanoate and pyruvate (cytosol to extracellular)

Catalysed by ACOT7, SLC16A4, SLC16A5, SLC16A3 and 3 morecytosol, extracellular spaceOne of 2 routes

all-trans-retinoic acidReach from here →

Propanoyl-CoA hydrolase
transport of propanoate and retinoate (cytosol to extracellular)

Catalysed by ACOT7, SLC16A4, SLC16A5, SLC16A8cytosol, extracellular spaceOne of 2 routes

CHEBI:15380Reach from here →

Propanoyl-CoA hydrolase
5-aminolevulinate synthase (2-amino-3-oxoadipate)

Catalysed by ACOT7, ALAS1, CPNE7cytosol, mitochondrial matrixOne of 8 routes

CHEBI:15477Reach from here →

Propanoyl-CoA hydrolase
glycine N-acyltransferase (2-methylbutyryl-CoA)

Catalysed by ACOT7, GLYAT, GLYATL2, GLYATL1cytosol, mitochondrial matrixOne of 2 routes

2-methylcrotonoyl-CoAReach from here →

Propanoyl-CoA hydrolase
Production of Tiglylcarnitine

Catalysed by ACOT7, CPT1A, CPT1BcytosolOne of 2 routes

isobutyryl-CoAReach from here →

Propanoyl-CoA hydrolase
acetyl-CoA C-acyltransferase (3-oxo-4-methyl-pentanoyl-CoA)

Catalysed by ACOT7, HADHA, ACAA2, HADHBcytosol, mitochondrial matrixOne of 3 routes

3-methylbut-2-enoyl-CoAReach from here →

Propanoyl-CoA hydrolase
glycine-N-acyltransferase (3-methylcrotonoylglycine)

Catalysed by ACOT7, GLYATcytosol, mitochondrial matrix

isovaleryl-CoAReach from here →

Propanoyl-CoA hydrolase
glycine N-acyltransferase (isovalerylglycine)

Catalysed by ACOT7, GLYAT, GLYATL2, GLYATL1cytosol, mitochondrial matrixOne of 3 routes

arachidonoyl-CoAReach from here →

Propanoyl-CoA hydrolase
Arachidonate:CoA ligase (AMP-forming)

Catalysed by ACOT7, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 11 routes

CHEBI:15519Reach from here →

Propanoyl-CoA hydrolase
propanoyl-CoA C-acyltransferase

Catalysed by ACOT7, ACAA1, SCP2, MYO5Bcytosol, peroxisomeOne of 2 routes

palmitoyl-CoAReach from here →

Propanoyl-CoA hydrolase
Palmitate:CoA ligase (AMP-forming)

Catalysed by ACOT7, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 11 routes

oleoyl-CoAReach from here →

Propanoyl-CoA hydrolase
Transport of octadecenoyl-CoA into Mitochondrial Matrix

Catalysed by ACOT7, CPT1A, CPT1C, CPT1BcytosolOne of 11 routes

phenylacetyl-CoAReach from here →

Propanoyl-CoA hydrolase
Phenylacetate:CoA ligase

Catalysed by ACOT7cytosolOne of 3 routes

CHEBI:15650Reach from here →

Propanoyl-CoA hydrolase
N-acetyl-LTE4 to leukotriene E4 conversion

Catalysed by ACOT7, ZDHHC11B, NAA10, ESCO2 and 29 morecytosolOne of 2 routes

CHEBI:15727Reach from here →

Propanoyl-CoA hydrolase
N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)

Catalysed by ACOT7, NAA10cytosol

CHEBI:15746Reach from here →

Propanoyl-CoA hydrolase
diamine N-acetyltransferase (N1-acetylspermine)

Catalysed by ACOT7, SAT1, SAT2cytosolOne of 2 routes

hexadecanoic acidReach from here →

Active Transport
Utilized Transport

No catalyst recordedmitochondrial matrix, cytosol, endoplasmic reticulumOne of 2 routes

11-cis-retinolReach from here →

Propanoyl-CoA hydrolase
Palmitoyl-CoA:retinol O-acyltransferase

Catalysed by ACOT7, DGAT1, LRAT, AWAT1 and 2 morecytosol

oxaloacetateReach from here →

Propanoyl-CoA hydrolase
ATP citrate lyase (citrate)

Catalysed by ACOT7, ACLYcytosol

(R)-3-hydroxybutyric acidReach from here →

Propanoyl-CoA hydrolase
transport of (R)-3-hydroxybutanoate and propanoate (cytosol to extracellular)

Catalysed by ACOT7, SLC16A4, SLC16A5, SLC16A7 and 1 morecytosol, extracellular spaceOne of 2 routes

anilineReach from here →

Propanoyl-CoA hydrolase
Acetyl-CoA:arylamine N-acetyltransferase

Catalysed by ACOT7, NAT2, NAT1cytosol

CHEBI:17312Reach from here →

Propanoyl-CoA hydrolase
N1,N12-diacetylspermine to N1-acetylspermine conversion

Catalysed by ACOT7cytosolOne of 2 routes

linoleic acidReach from here →

Active Transport
Utilized Transport

No catalyst recordedmitochondrial matrix, cytosol, endoplasmic reticulumOne of 2 routes

O-hexadecanoyl-(R)-carnitineReach from here →

Active Transport
palmitoyl-CoA:L-carnitine O-palmitoyltransferase

Catalysed by CPT2, CPT1Amitochondrial matrix, cytosol, peroxisomeOne of 10 routes

L-cysteineReach from here →

Propanoyl-CoA hydrolase
N-acetylglutamate synthase (N-acetyl-L-cysteine)

Catalysed by ACOT7, NAGScytosol, mitochondrial matrix

(7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →

Propanoyl-CoA hydrolase
Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

Catalysed by ACOT7, HADHA, ACADVL, HADHBcytosol, mitochondrial matrix

CHEBI:17927Reach from here →

Propanoyl-CoA hydrolase
N1,N8-diacetylspermidine to N1-acetylspermidine conversion

Catalysed by ACOT7cytosol

O-octanoyl-(R)-carnitineReach from here →

Active Transport
solute carrier (L-carnitine)

Catalysed by SLC25A20mitochondrial matrix, cytosolOne of 7 routes

(5Z)-dodecenoyl-CoAReach from here →

Propanoyl-CoA hydrolase
acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

Catalysed by ACOT7, HADHA, ACAA2, HADHBcytosol, mitochondrial matrixOne of 2 routes

(11Z)-docosenoyl-CoA(4-)Reach from here →

Propanoyl-CoA hydrolase
long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)

Catalysed by ACOT7, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 5 routes

(7Z)-tetradecenoyl-CoAReach from here →

Propanoyl-CoA hydrolase
long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)

Catalysed by ACOT7, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 8 routes

(4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →

Propanoyl-CoA hydrolase
Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

Catalysed by ACOT7, HADHA, ACADVL, HADHBcytosol, mitochondrial matrixOne of 3 routes

(7Z,10Z)-hexadecadienoyl-CoAReach from here →

Propanoyl-CoA hydrolase
Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

Catalysed by ACOT7, HADHA, ACADVL, HADHBcytosol, mitochondrial matrix

(4Z,7Z)-decadienoyl-CoAReach from here →

Propanoyl-CoA hydrolase
Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

Catalysed by ACOT7, ECHS1, ACAA2, HADHcytosol, mitochondrial matrixOne of 2 routes

(5Z)-octenoyl-CoAReach from here →

Propanoyl-CoA hydrolase
Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

Catalysed by ACOT7, ECHS1, ACAA2, HADHcytosol, mitochondrial matrixOne of 2 routes

alpha-linolenic acidReach from here →

Active Transport
Utilized Transport

No catalyst recordedmitochondrial matrix, cytosol, endoplasmic reticulum

CHEBI:27540Reach from here →

Propanoyl-CoA hydrolase
medium-chain acyl-CoA ligase (hexanoic acid)

Catalysed by ACOT7, ACSM4, ACSM1, ACSM2A and 3 morecytosolOne of 6 routes

elaidic acidReach from here →

Propanoyl-CoA hydrolase
long-chain-fatty-acid-CoA ligase (elaidate)

Catalysed by ACOT7, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 5 routes

CHEBI:28701Reach from here →

Propanoyl-CoA hydrolase
Propanoyl-CoA:acetyl-CoA C-acyltransferase

Catalysed by ACOT7, ACAA1, SCP2, MYO5Bcytosol, peroxisomeOne of 7 routes