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Proteins/UNIPROT:Q9GZV3
High-affinity Na(+)-coupled choline transmembrane symporter. Functions as an electrogenic, voltage-dependent transporter with variable charge/choline stoichiometry. Choline uptake and choline-induced current is also Cl(-)-dependent where Cl(-) is likely a regulatory ion rather than cotransported ion. Plays a critical role in acetylcholine (ACh) synthesis by taking up the substrate choline from the synaptic cleft into the presynaptic nerve terminals after neurotransmitter release. SLC5A7/CHT1-mediated choline high-affinity transport in cholinergic neurons is the rate-limiting step for production of ACh, thereby facilitating communication by subsequent action potentials. Localized predominantly in presynaptic terminal intracellular organelles, and translocated to the plasma membrane in active form in response to neuronal activity..
Function from UniProtKB (Q9GZV3), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
3 rows
25 statements
25 statements · 5 reference databases · Subject: SLC5A7 · Sources: Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
3 reactions
choline+sodium(1+)choline+sodium(1+)
Transported by SLC5A7
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR07734CC BY 4.0Reference data
chlorine(.)+choline+sodium(1+)chlorine(.)+choline+sodium(1+)
Transported by SLC5A7
5 names
Resolves to: SLC5A7
Human-GEM MAR09620CC BY 4.0Reference data
choline+nsodium(1+)choline+nsodium(1+)
Transported by SLC5A7
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:76443CC BY 4.0Reference data