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Proteins/UNIPROT:P21912
Iron-sulfur protein (IP) subunit of the succinate dehydrogenase complex (mitochondrial respiratory chain complex II), responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate (By similarity). Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate (By similarity)..
Function from UniProtKB (P21912), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
9 rows
641 statements
641 statements · 8 reference databases · Subject: SDHB · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways · Rows fetched: 300
4 reactions
fumaric acid+ubiquinolsuccinate(2-)+ubiquinones
Catalysed by SDHD & SDHB & SDHA & SDHC
Reaction pageReversibleBalancedEC 1.3.5.1mitochondrial matrix
Human-GEM MAR04652CC BY 4.0Reference data
a quinone+succinate(2-)fumaric acid+a quinol
Catalysed by SDHB
5 names
Resolves to: SDHB
Rhea RHEA:40523CC BY 4.0Reference data
(R)-malate+a quinoneenol-oxaloacetate+a quinol
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:79827CC BY 4.0Reference data
(S)-malate+a quinoneenol-oxaloacetate+a quinol
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:79831CC BY 4.0Reference data