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Proteins/UNIPROT:Q9UBX3
Catalyzes the electroneutral exchange or flux of physiologically important metabolites such as dicarboxylates (malonate, malate, succinate), inorganic sulfur-containing anions, and phosphate, across the mitochondrial inner membrane. Substrate exchange across the membrane occurs consecutively with one substrate being transported first, then dissociating from the substrate binding site before the second substrate binds for transport in the opposite direction. Does not transport glutathione (By similarity). Plays an important role in gluconeogenesis, fatty acid metabolism, urea synthesis, and sulfur metabolism, particularly in liver, by supplying the substrates for the different metabolic processes. Regulates fatty acid release from adipocytes, and contributes to systemic insulin sensitivity (By similarity)..
Function from UniProtKB (Q9UBX3), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · transported by
1 compound
1 compound.
0 reported routes1 assembled route
1 row
179 statements
179 statements · 6 reference databases · Subject: SLC25A10 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea
29 reactions
fumaric acid+phosphate(3-)fumaric acid+phosphate(3-)
Transported by SLC25A10
Reaction pageLeft to rightBalancedcytosol, mitochondrial matrix
Human-GEM MAR03971CC BY 4.0Reference data
2-oxoglutarate(2-)+succinate(2-)2-oxoglutarate(2-)+succinate(2-)
Transported by SLC25A10
Reaction pageReversibleBalancedcytosol, mitochondrial matrix
2 names
Resolves to: SLC25A10
fumaric acid+succinate(2-)fumaric acid+succinate(2-)
Transported by SLC25A10
Reaction pageReversibleBalancedcytosol, mitochondrial matrix
Human-GEM MAR04854CC BY 4.0Reference data
phosphate(3-)+succinate(2-)phosphate(3-)+succinate(2-)
Transported by SLC25A10
Reaction pageLeft to rightBalancedmitochondrial matrix, cytosol
Human-GEM MAR04862CC BY 4.0Reference data
succinate(2-)+sulfatesuccinate(2-)+sulfate
Transported by SLC25A10
Reaction pageReversibleBalancedcytosol, mitochondrial matrix
Human-GEM MAR04863CC BY 4.0Reference data
succinate(2-)+sulfitesuccinate(2-)+sulfite
Transported by SLC25A10
Reaction pageReversibleBalancedcytosol, mitochondrial matrix
Human-GEM MAR04864CC BY 4.0Reference data
(S)-malate+phosphate(3-)(S)-malate+phosphate(3-)
Transported by SLC25A10
Reaction pageLeft to rightBalancedcytosol, mitochondrial matrix
Human-GEM MAR04865CC BY 4.0Reference data
(S)-malate+sulfate(S)-malate+sulfate
Transported by SLC25A10
Reaction pageReversibleBalancedcytosol, mitochondrial matrix
Human-GEM MAR04867CC BY 4.0Reference data
(S)-malate+sulfite(S)-malate+sulfite
Transported by SLC25A10
Reaction pageReversibleBalancedcytosol, mitochondrial matrix
Human-GEM MAR04868CC BY 4.0Reference data
malonic acid+phosphate(3-)malonic acid+phosphate(3-)
Transported by SLC25A10
Reaction pageLeft to rightBalancedcytosol, mitochondrial matrix
Human-GEM MAR04870CC BY 4.0Reference data
malonic acid+sulfatemalonic acid+sulfate
Transported by SLC25A10
Reaction pageReversibleBalancedcytosol, mitochondrial matrix
Human-GEM MAR04871CC BY 4.0Reference data
malonic acid+sulfitemalonic acid+sulfite
Transported by SLC25A10
Reaction pageReversibleBalancedcytosol, mitochondrial matrix
Human-GEM MAR04872CC BY 4.0Reference data