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butanal

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

19 compounds within 3 steps: 1 in 1, 3 in 2, 15 in 3

Does it reach a compound?

One step

butanoateReach from here →
1. butanal + NAD(+) + H2O = butanoate + NADH + 2 H(+)
Catalysed by ALDH9A1

Two steps

butanoyl-CoAReach from here →
1. butanal + NAD(+) + H2O = butanoate + NADH + 2 H(+)
2. butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
Catalysed by ALDH9A1, ACSM1, ACSM2A, ACSM3 and 2 more
dehydroepiandrosterone 3-sulfateReach from here →
1. butanal + NAD(+) + H2O = butanoate + NADH + 2 H(+)
2. dehydroepiandrosterone 3-sulfate(in) + butanoate(out) = dehydroepiandrosterone 3-sulfate(out) + butanoate(in)
Catalysed by ALDH9A1, SLC22A9inner side of the membrane, outer side of the membraneOne of 2 routes
estrone 3-sulfateReach from here →
1. butanal + NAD(+) + H2O = butanoate + NADH + 2 H(+)
2. butanoate(out) + estrone 3-sulfate(in) = butanoate(in) + estrone 3-sulfate(out)
Catalysed by ALDH9A1, SLC22A9inner side of the membrane, outer side of the membraneOne of 2 routes

Three steps

(S)-carnitineReach from here →
Catalysed by ALDH9A1, ACSM1, ACSM2A, ACSM3 and 5 moremitochondrial matrix, cytosolOne of 2 routes
CHEBI:1146900Reach from here →

Catalysed by ALDH9A1, ACSM1, ACSM2A, ACSM3 and 5 more

cytosol

One of 4 routes

S-butanoyl-4'-phosphopantetheineReach from here →

butanal + NAD(+) + H2O = butanoate + NADH + 2 H(+)
butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
butanoyl-CoA + H2O = S-butanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

Catalysed by ALDH9A1, ACSM1, ACSM2A, ACSM3 and 5 more

2,4-dinitrophenyl-S-glutathioneReach from here →

butanal + NAD(+) + H2O = butanoate + NADH + 2 H(+)
butanoate(out) + estrone 3-sulfate(in) = butanoate(in) + estrone 3-sulfate(out)
transport of estrone 3-sulfate (cytosol to extracellular)

Catalysed by ALDH9A1, SLC22A9, SLCO1B1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

sulfateReach from here →

butanal + NAD(+) + H2O = butanoate + NADH + 2 H(+)
butanoate(out) + estrone 3-sulfate(in) = butanoate(in) + estrone 3-sulfate(out)
Estrone 3-sulfate sulfohydrolase

Catalysed by ALDH9A1, SLC22A9, STSinner side of the membrane, outer side of the membrane, cytosolOne of 6 routes

estroneReach from here →

butanal + NAD(+) + H2O = butanoate + NADH + 2 H(+)
butanoate(out) + estrone 3-sulfate(in) = butanoate(in) + estrone 3-sulfate(out)
Estrone 3-sulfate sulfohydrolase

Catalysed by ALDH9A1, SLC22A9, STSinner side of the membrane, outer side of the membrane, cytosolOne of 3 routes

propanoateReach from here →

butanal + NAD(+) + H2O = butanoate + NADH + 2 H(+)
butanoate(out) + estrone 3-sulfate(in) = butanoate(in) + estrone 3-sulfate(out)
propanoate(in) + estrone 3-sulfate(out) = propanoate(out) + estrone 3-sulfate(in)

Catalysed by ALDH9A1, SLC22A9inner side of the membrane, outer side of the membraneOne of 4 routes

1-butanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →

butanal + NAD(+) + H2O = butanoate + NADH + 2 H(+)
butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
2-(9Z-octadecenoyl)-glycerol + butanoyl-CoA = 1-butanoyl-2-(9Z-octadecenoyl)-glycerol + CoA

Catalysed by ALDH9A1, ACSM1, ACSM2A, ACSM3 and 4 more

O-butanoyl-(R)-carnitineReach from here →

butanal + NAD(+) + H2O = butanoate + NADH + 2 H(+)
butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
butanoyl-CoA + (R)-carnitine = O-butanoyl-(R)-carnitine + CoA

Catalysed by ALDH9A1, ACSM1, ACSM2A, ACSM3 and 3 more

3beta-hydroxyandrost-5-en-17-oneReach from here →

butanal + NAD(+) + H2O = butanoate + NADH + 2 H(+)
dehydroepiandrosterone 3-sulfate(in) + butanoate(out) = dehydroepiandrosterone 3-sulfate(out) + butanoate(in)
3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase

Catalysed by ALDH9A1, SLC22A9, STSinner side of the membrane, outer side of the membrane, cytosolOne of 3 routes

butyric acidReach from here →

butanal + NAD(+) + H2O = butanoate + NADH + 2 H(+)
butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
Butyryl-CoA hydrolase

Catalysed by ALDH9A1, ACSM1, ACSM2A, ACSM3 and 3 morecytosol

glutarateReach from here →

butanal + NAD(+) + H2O = butanoate + NADH + 2 H(+)
butanoate(out) + estrone 3-sulfate(in) = butanoate(in) + estrone 3-sulfate(out)
estrone 3-sulfate(out) + glutarate(in) = estrone 3-sulfate(in) + glutarate(out)

Catalysed by ALDH9A1, SLC22A9, SLC22A24, SLC22A8 and 1 moreinner side of the membrane, outer side of the membraneOne of 4 routes

pentanoateReach from here →

butanal + NAD(+) + H2O = butanoate + NADH + 2 H(+)
butanoate(out) + estrone 3-sulfate(in) = butanoate(in) + estrone 3-sulfate(out)
pentanoate(in) + estrone 3-sulfate(out) = pentanoate(out) + estrone 3-sulfate(in)

Catalysed by ALDH9A1, SLC22A9inner side of the membrane, outer side of the membraneOne of 4 routes

(2E)-butenoyl-CoAReach from here →

butanal + NAD(+) + H2O = butanoate + NADH + 2 H(+)
butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
butanoyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase

Catalysed by ALDH9A1, ACSM1, ACSM2A, ACSM3 and 4 moremitochondrial matrixOne of 2 routes

16alpha-hydroxydehydroepiandrosterone 3-sulfateReach from here →

butanal + NAD(+) + H2O = butanoate + NADH + 2 H(+)
dehydroepiandrosterone 3-sulfate(in) + butanoate(out) = dehydroepiandrosterone 3-sulfate(out) + butanoate(in)
dehydroepiandrosterone 3-sulfate + reduced [NADPH--hemoprotein reductase] + O2 = 16alpha-hydroxydehydroepiandrosterone 3-sulfate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by ALDH9A1, SLC22A9, CYP3A7inner side of the membrane, outer side of the membrane