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Proteins/UNIPROT:O76082
Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 11.3. In intestinal epithelia, transports the quorum-sensing pentapeptide CSF (competence and sporulation factor) from B.subtilis which induces cytoprotective heat shock proteins contributing to intestinal homeostasis. May also contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (Probable)..
[Isoform 3]: Retained in the ER, unable to perform carnitine uptake..
Function from UniProtKB (O76082), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 4 · transported by
4 compounds
4 compounds.
0 reported routes4 assembled routes
1 row
162 statements
162 statements · 7 reference databases · Subject: SLC22A5 · Sources: Bgee, gene ontology, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
86 reactions
Transported by SLC22A5
Reaction pageReversibleBalancedcytosol, endoplasmic reticulum
Human-GEM MAR02777CC BY 4.0Reference data
(S)-carnitine+O-acetyl-(R)-carnitine(S)-carnitine+O-acetyl-(R)-carnitine
Transported by SLC22A5
Reaction pageReversibleBalancedcytosol, endoplasmic reticulum
Human-GEM MAR02778CC BY 4.0Reference data
3 names
Resolves to: SLC22A5
Transported by SLC22A5
Reaction pageReversibleBalancedendoplasmic reticulum, cytosol
Human-GEM MAR02787CC BY 4.0Reference data
(S)-carnitine+MAM03049r(S)-carnitine+MAM03049c
Transported by SLC22A5
Reaction pageReversibleBalancedcytosol, endoplasmic reticulum
Human-GEM MAR02789CC BY 4.0Reference data
(S)-carnitine+MAM02973r(S)-carnitine+MAM02973c
Transported by SLC22A5
Reaction pageReversibleBalancedcytosol, endoplasmic reticulum
Human-GEM MAR02791CC BY 4.0Reference data
(S)-carnitine+(5E)-tetradecenoyl-(R)-carnitine(S)-carnitine+(5E)-tetradecenoyl-(R)-carnitine
Transported by SLC22A5
Reaction pageReversibleBalancedcytosol, endoplasmic reticulum
Human-GEM MAR02793CC BY 4.0Reference data
(S)-carnitine+MAM02975r(S)-carnitine+MAM02975c
Transported by SLC22A5
Reaction pageReversibleBalancedcytosol, endoplasmic reticulum
Human-GEM MAR02795CC BY 4.0Reference data
(S)-carnitine+MAM02976r(S)-carnitine+MAM02976c
Transported by SLC22A5
Reaction pageReversibleBalancedcytosol, endoplasmic reticulum
Human-GEM MAR02797CC BY 4.0Reference data
(S)-carnitine+MAM02688r(S)-carnitine+MAM02688c
Transported by SLC22A5
Reaction pageReversibleBalancedcytosol, endoplasmic reticulum
Human-GEM MAR02799CC BY 4.0Reference data
(S)-carnitine+O-hexadecanoyl-(R)-carnitine(S)-carnitine+O-hexadecanoyl-(R)-carnitine
Transported by SLC22A5
Reaction pageReversibleBalancedcytosol, endoplasmic reticulum
Human-GEM MAR02801CC BY 4.0Reference data
MAM02117r+(S)-carnitineMAM02117c+(S)-carnitine
Transported by SLC22A5
Reaction pageReversibleBalancedendoplasmic reticulum, cytosol
Human-GEM MAR02805CC BY 4.0Reference data
(S)-carnitine+MAM02676r(S)-carnitine+MAM02676c
Transported by SLC22A5
Reaction pageReversibleBalancedcytosol, endoplasmic reticulum
Human-GEM MAR02807CC BY 4.0Reference data