Compound
isovaleryl-CoA
A methylbutanoyl-CoA is the S-isovaleryl derivative of coenzyme A.
Definition from ChEBI (CHEBI:15487), read 2026-09-23. CC BY 4.0.
What it touches on the way
Mechanistic reach
9 entities
9 entities reached.
0 reported hops9 assembled from the scaffold
- CPT1AProteinUNIPROT:P50416substrate ofInferred only28 paths28 endpoints
- GLYATProteinUNIPROT:Q6IB77substrate ofInferred only15 paths15 endpoints
- GLYATL2ProteinUNIPROT:Q8WU03substrate ofInferred only11 paths11 endpoints
- GLYATL1ProteinUNIPROT:Q969I3substrate ofInferred only11 paths11 endpoints
- ACADSBProteinUNIPROT:P45954substrate ofInferred only10 paths10 endpoints
- DBIProteinUNIPROT:P07108transported byInferred only9 paths9 endpoints
- IVDProteinUNIPROT:P26440substrate ofInferred only9 paths9 endpoints
- CPT1BProteinUNIPROT:Q92523substrate ofInferred only8 paths8 endpoints
- CPT1CProteinUNIPROT:Q8TCG5substrate ofInferred only4 paths4 endpoints
What the reference databases state
Statements
11 statements
11 statements · 1 reference database · Subject: isovaleryl-CoA · Sources: Human-GEM
- 3-methylbut-2-enoyl-CoA is converted to isovaleryl-CoACompoundHuman-GEM MAR03770Inferred only
- isovaleryl-CoA is converted to 3-methylbut-2-enoyl-CoACompoundHuman-GEM MAR03770Inferred only
- isovaleryl-CoA is a substrate of ACADSBProteinHuman-GEM MAR03770Inferred only
- isovaleryl-CoA is a substrate of CPT1AProteinHuman-GEM MAR04707Inferred only
- isovaleryl-CoA is a substrate of CPT1BProteinHuman-GEM MAR04707Inferred only
- isovaleryl-CoA is a substrate of CPT1CProteinHuman-GEM MAR04707Inferred only
- isovaleryl-CoA is a substrate of GLYATProteinHuman-GEM MAR03771Inferred only
- isovaleryl-CoA is a substrate of GLYATL1ProteinHuman-GEM MAR03771Inferred only
- isovaleryl-CoA is a substrate of GLYATL2ProteinHuman-GEM MAR03771Inferred only
- isovaleryl-CoA is a substrate of IVDProteinHuman-GEM MAR03770Inferred only
- isovaleryl-CoA is transported by DBIProteinHuman-GEM MAR06593Inferred only
Reactions
16 reactions
3-methylbut-2-enoyl-CoA+FADH2FAD+isovaleryl-CoA
Reaction pageReversibleBalancedEC 1.3.8.4, 1.3.8.5GO:0005759
Human-GEM MAR03770CC BY 4.0Reference data
CHEBI:1146900+proton+MAM02190mglycine+isovaleryl-CoA
Catalysed by GLYAT or GLYATL2 or GLYATL1
Reaction pageReversibleBalancedEC 2.3.1.13GO:0005759
Human-GEM MAR03771CC BY 4.0Reference data
isovaleryl-CoA+(S)-carnitineCHEBI:1146900+MAM03706c
Catalysed by CPT1A or CPT1C or CPT1B
Reaction pageReversibleBalancedEC 2.3.1.21GO:0005829
Human-GEM MAR04707CC BY 4.0Reference data
CHEBI:1146900+MAM02858mMAM01701m+isovaleryl-CoA
Catalysed by DBT
Reaction pageLeft to rightBalancedEC 2.3.1.168GO:0005759
Human-GEM MAR06422CC BY 4.0Reference data
Transported by DBI
Reaction pageLeft to rightBalancedGO:0005759, GO:0005829
Human-GEM MAR06593CC BY 4.0Reference data
isovaleryl-CoA+oxidized [electron-transfer flavoprotein]+hydron3-methylbut-2-enoyl-CoA+reduced [electron-transfer flavoprotein]
Catalysed by IVD
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:12276CC BY 4.0Reference data
isovaleryl-CoA+3malonyl-CoA+3hydronCHEBI:15951+3carbon dioxide+4coenzyme A(4-)
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:23572CC BY 4.0Reference data
4-methyl-2-oxopentanoate+NAD(1-)+coenzyme A(4-)isovaleryl-CoA+carbon dioxide+NADH(2-)
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:25177CC BY 4.0Reference data
isovaleryl-CoA+S-adenosyl-L-methionineCHEBI:74958+S-methyl-5'-thioadenosine+coenzyme A(4-)+hydron
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:37471CC BY 4.0Reference data
isovaleryl-CoA+malonyl-[ACP]+hydron5-methyl-3-oxohexanoyl-[ACP]+carbon dioxide+coenzyme A(4-)
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:42272CC BY 4.0Reference data
isovaleryl-CoA+(R)-carnitineCHEBI:70819+coenzyme A(4-)
Catalysed by CRAT
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:44984CC BY 4.0Reference data
CHEBI:48942+ATP(4-)+coenzyme A(4-)isovaleryl-CoA+AMP+diphosphate(3-)
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:46184CC BY 4.0Reference data
Other names
15 names
Resolves to: isovaleryl-CoA
- Also called
- 3-Methylbutanoyl-CoA3-methylbutanoyl-coenzyme A3-methylbutyryl-CoA3-methylbutyryl-coenzyme Abeta-methylbutanoyl-CoAbeta-methylbutanoyl-coenzyme Abeta-methylbutyryl-CoAbeta-methylbutyryl-coenzyme Aisovaleryl-coenzyme AS-(3-methylbutanoyl)-coenzyme Aβ-methylbutanoyl-CoAβ-methylbutanoyl-coenzyme Aβ-methylbutyryl-CoAβ-methylbutyryl-coenzyme A
- Systematic name
- 3'-phosphoadenosine 5'-{3-[(3R)-3-hydroxy-2,2-dimethyl-4-{[3-({2-[(3-methylbutanoyl)sulfanyl]ethyl}amino)-3-oxopropyl]amino}-4-oxobutyl] dihydrogen diphosphate}