Compound

10-formyltetrahydrofolic acid

A form of tetrahydrofolate that acts as a donor of formyl groups in anabolism. In these reactions 10-formyltetrahydrofolic acid is used as a substrate in formyltransferase reactions, which is important in purine biosynthesis.

Definition from ChEBI (CHEBI:15637), read 2026-09-23. CC BY 4.0.

CHEBI:15637ChEBI

Open in the graph

What it touches on the way

Mechanistic reach

10 entities

10 entities reached.

0 reported hops10 assembled from the scaffold

What the reference databases state

Statements

16 statements

16 statements · 1 reference database · Subject: 10-formyltetrahydrofolic acid · Sources: Human-GEM

Order

(6R)-5,10-methenyltetrahydrofolate is converted to 10-formyltetrahydrofolic acidCompoundHuman-GEM MAR04505Inferred only
10-formyltetrahydrofolic acid is converted to (6R)-5,10-methenyltetrahydrofolateCompoundHuman-GEM MAR04503Inferred only
10-formyltetrahydrofolic acid is converted to (6R)-5,10-methenyltetrahydrofolateCompoundHuman-GEM MAR04505Inferred only
(6R)-5,10-methenyltetrahydrofolate is converted to 10-formyltetrahydrofolic acidCompoundHuman-GEM MAR04503Inferred only
10-formyltetrahydrofolic acid is converted to 5,6,7,8-tetrahydrofolic acidCompoundHuman-GEM MAR04336Inferred only
10-formyltetrahydrofolic acid is metabolised by ALDH1L1ProteinHuman-GEM MAR04336Inferred only
10-formyltetrahydrofolic acid is metabolised by ALDH1L2ProteinHuman-GEM MAR04336Inferred only
10-formyltetrahydrofolic acid is a substrate of ATICProteinHuman-GEM MAR04814Inferred only
10-formyltetrahydrofolic acid is a substrate of FPGSProteinHuman-GEM MAR07908Inferred only
10-formyltetrahydrofolic acid is a substrate of FPGSProteinHuman-GEM MAR07909Inferred only
10-formyltetrahydrofolic acid is a substrate of GARTProteinHuman-GEM MAR04806Inferred only
10-formyltetrahydrofolic acid is a substrate of MTFMTProteinHuman-GEM MAR05144Inferred only

Show the remaining 4

10-formyltetrahydrofolic acid is a substrate of MTHFD1ProteinHuman-GEM MAR04503Inferred only
10-formyltetrahydrofolic acid is a substrate of MTHFD1LProteinHuman-GEM MAR04505Inferred only
10-formyltetrahydrofolic acid is a substrate of MTHFD2ProteinHuman-GEM MAR04505Inferred only
10-formyltetrahydrofolic acid is a substrate of MTHFD2LProteinHuman-GEM MAR04505Inferred only

Reactions

15 reactions

10-formyltetrahydrofolic acid10-formyltetrahydrofolic acid
Reaction pageReversibleBalancedGO:0005829, GO:0005759
Human-GEM MAR00038CC BY 4.0Reference data
10-formyltetrahydrofolic acid+water+NADP(3-)carbon dioxide+proton+NADPH(4-)+5,6,7,8-tetrahydrofolic acid
Catalysed by ALDH1L2 or ALDH1L1
Reaction pageLeft to rightBalancedEC 1.5.1.6GO:0005829
Human-GEM MAR04336CC BY 4.0Reference data
ATP+formic acid+5,6,7,8-tetrahydrofolic acid10-formyltetrahydrofolic acid+ADP+phosphate(3-)
Catalysed by MTHFD1
Reaction pageLeft to rightBalancedEC 3.5.4.9, 6.3.4.3GO:0005829
Human-GEM MAR04338CC BY 4.0Reference data
ATP+formic acid+5,6,7,8-tetrahydrofolic acid10-formyltetrahydrofolic acid+ADP+phosphate(3-)
Catalysed by MTHFD2 or MTHFD1L or MTHFD2L
Reaction pageLeft to rightBalancedEC 3.5.4.9, 6.3.4.3GO:0005759
Human-GEM MAR04340CC BY 4.0Reference data
10-formyltetrahydrofolic acid+proton(6R)-5,10-methenyltetrahydrofolate+water
Catalysed by MTHFD1
Reaction pageReversibleBalancedEC 3.5.4.9GO:0005829
Human-GEM MAR04503CC BY 4.0Reference data
10-formyltetrahydrofolic acid+proton(6R)-5,10-methenyltetrahydrofolate+water
Catalysed by MTHFD2 or MTHFD1L or MTHFD2L
Reaction pageReversibleBalancedEC 3.5.4.9GO:0005759
Human-GEM MAR04505CC BY 4.0Reference data
10-formyltetrahydrofolic acid+N(1)-(5-phospho-D-ribosyl)glycinamideproton+N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide+5,6,7,8-tetrahydrofolic acid
Catalysed by GART
Reaction pageLeft to rightBalancedEC 2.1.2.2GO:0005829
Human-GEM MAR04806CC BY 4.0Reference data
10-formyltetrahydrofolic acid+5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamideCHEBI:18381+5,6,7,8-tetrahydrofolic acid
Catalysed by ATIC
Reaction pageReversibleBalancedEC 2.1.2.3GO:0005829
Human-GEM MAR04814CC BY 4.0Reference data
10-formyltetrahydrofolic acid+Met-tRNA(Met)MAM02576c+5,6,7,8-tetrahydrofolic acid
Catalysed by MTFMT
Reaction pageLeft to rightBalance undeterminableEC 2.1.2.9GO:0005829
Human-GEM MAR05144CC BY 4.0Reference data
10-formyltetrahydrofolic acid+4ATP+4L-glutamate(1-)MAM00267c+4ADP+4proton+4phosphate(3-)
Catalysed by FPGS
Reaction pageLeft to rightBalancedEC 6.3.2.17GO:0005829
Human-GEM MAR07908CC BY 4.0Reference data
10-formyltetrahydrofolic acid+4ATP+4L-glutamate(1-)MAM00267m+4ADP+4proton+4phosphate(3-)
Catalysed by FPGS
Reaction pageLeft to rightBalancedEC 6.3.2.17GO:0005759
Human-GEM MAR07909CC BY 4.0Reference data
MAM00267l+4water10-formyltetrahydrofolic acid+4L-glutamate(1-)
Catalysed by GGH
Reaction pageLeft to rightBalancedEC 3.4.19.9GO:0005764
Human-GEM MAR07916CC BY 4.0Reference data

Show the remaining 3

Other names

15 names

Resolves to: 10-formyltetrahydrofolic acid

Also called: 10-formyl-(6RS)-tetrahydrofolic acid10-formyl-5,6,7,8-tetrahydrofolic acid10-formyl-THF10-Formyltetrahydrofolate10-formyltetrahydropteroylglutamic acid10-FTHF10-HCO-H4folic acidN-(10-formyl-5,6,7,8-tetrahydropteroyl)-L-glutamic acidN(10)-formyl-5,6,7,8-tetrahydrofolic acidN(10)-formyl-THFN(10)-formyltetrahydrofolic acidN10-formyl-5,6,7,8-tetrahydrofolic acidN10-formyl-THFN10-formyltetrahydrofolic acid
Systematic name: N-(4-{[(2-amino-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl](formyl)amino}benzoyl)-L-glutamic acid