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Proteins/UNIPROT:O95258
Transports inorganic anions (sulfate, sulfite, thiosulfate and phosphate) and, to a lesser extent, a variety of dicarboxylates (e.g. malonate, malate and citramalate) and, even more so, aspartate and glutamate and tricarboxylates. May catalyze the export of sulfite and thiosulfate (the hydrogen sulfide degradation products) from the mitochondria, thereby modulating the level of the hydrogen sulfide (Probable). Also can mediate a very low unidirectional transport of anions including sulfate, phosphate, (S)-malate, citrate, L-aspartate and L-glutamate. Maintains oxidative balance (through uncoupling activities) and ATP production (by modifying mitochondrial membrane potential). Is able to transport protons across lipid membranes. Also exhibits transmembrane chloride transport activity to a lesser extent. May modify mitochondrial respiratory efficiency and mitochondrial oxidant production (By similarity)..
Function from UniProtKB (O95258), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
176 statements
176 statements · 7 reference databases · Subject: SLC25A14 · Sources: Bgee, gene ontology, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
24 reactions
6 names
Resolves to: SLC25A14
Reaction pageLeft to rightBalancedmitochondrial intermembrane space, mitochondrial matrix
Human-GEM MAR13080CC BY 4.0Reference data
Transported by GABRR3 or GPHRA or KCNK1 or CLIC1 or GABRP or CLDN4 or GABRD or CLIC2 or SLC26A4 or GLRA3 or BEST1 or KCNK2 and 69 more alternatives
Reaction pageRight to leftBalanced
Rhea RHEA:29823CC BY 4.0Reference data
hydrogenphosphatehydrogenphosphate
Transported by SLC25A14 or UCP2 or SLC25A30 or SLC17A7 or SLC17A6 or XPR1
Reaction pageLeft to rightBalanced
Rhea RHEA:32823CC BY 4.0Reference data
Transported by SLC25A14 or SLC35G1 or SFXN5 or ANKH
Reaction pageLeft to rightBalanced
Rhea RHEA:33183CC BY 4.0Reference data
Transported by SLC25A14 or SLC25A27 or MT-ATP6 or SLC25A5 or ATP5MC1 or SLC25A4 or SLC25A6 or UCP1 or SLC11A2 or UCP2 or SLC25A11 or OTOP3 and 6 more alternatives
Reaction pageLeft to rightBalanced
Rhea RHEA:34979CC BY 4.0Reference data
Transported by SLC25A14 or SLC25A30 or SLC26A7
Reaction pageDirection not assertedBalanced
Rhea RHEA:34983CC BY 4.0Reference data
Transported by SLC38A8 or SLC25A14 or UCP2 or LRRC8A or PANX1 or SLC17A5
Reaction pageLeft to rightBalanced
Rhea RHEA:66332CC BY 4.0Reference data
L-glutamate(1-)L-glutamate(1-)
Transported by KCNK1 or BEST1 or KCNK2 or SLC25A14 or VDAC1 or LRRC8A or SLC38A6 or SLC17A8 or BEST2 or PANX1 or TTYH2 or TTYH3 and 5 more alternatives
Reaction pageReversibleBalanced
Rhea RHEA:66336CC BY 4.0Reference data
(S)-malate+sulfate(S)-malate+sulfate
Transported by SLC25A14 or SLC25A30 or SLC25A10
Reaction pageDirection not assertedBalanced
Rhea RHEA:71615CC BY 4.0Reference data
sulfate+hydrogenphosphatesulfate+hydrogenphosphate
Transported by SLC25A14 or SLC25A30 or SLC25A10
Reaction pageDirection not assertedBalanced
Rhea RHEA:71631CC BY 4.0Reference data