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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed

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Catalyst

The evidence graph for human biochemistry. Every edge carries its source, its study design, and a grade computed from both.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Reaction

(S)-malate+NAD(+)carbon dioxide+NADH(2-)+pyruvate

Left to right · Balanced · EC 1.1.1.38, 1.1.1.39

Compartment: GO:0005759

Inferred

Reference data, not a finding. Evidence key

Catalysts

ME2
ME3

Human-GEM MAR04087·2.0.1·CC BY 4.0Reference data