10-formyltetrahydrofolic acid

1. 10-formyltetrahydrofolate:5'-phosphoribosylglycinamide formyltransferase

Catalysed by GARTcytosol

1. phosphoribosylaminoimidazolecarboxamide formyltransferase (10-formyl-THF)

Catalysed by ATICcytosol

1. 10-formyltetrahydrofolate:NADP+ oxidoreductase

Catalysed by ALDH1L1, ALDH1L2cytosolOne of 4 routes

1. 5,10-Methenyltetrahydrofolate 5-hydrolase (decyclizing)

Catalysed by MTHFD1cytosolOne of 2 routes

1. 5,10-Methenyltetrahydrofolate 5-hydrolase (decyclizing)
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)-5,10-methenyltetrahydrofolate + NADH

Catalysed by MTHFD1, MTHFD2, MTHFD2Lcytosol

1. 10-formyltetrahydrofolate:NADP+ oxidoreductase
2. histamine N-methyltransferase (SAM)

Catalysed by ALDH1L1, ALDH1L2, HNMTcytosol

1. 10-formyltetrahydrofolate:NADP+ oxidoreductase
2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
3. bile acid-CoA: amino acid N-acyltransferase

Catalysed by ALDH1L1, ALDH1L2, SHMT1, BAATcytosol, peroxisomeOne of 28 routes

1. 10-formyltetrahydrofolate:NADP+ oxidoreductase
2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
3. N(omega)-methyl-L-arginine + glyoxylate = 5-(3-methylguanidino)-2-oxopentanoate + glycine