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Proteins/UNIPROT:P23368
NAD-dependent mitochondrial malic enzyme that catalyzes the oxidative decarboxylation of malate to pyruvate..
Function from UniProtKB (P23368), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
446 statements
446 statements · 9 reference databases · Subject: ME2 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways · Rows fetched: 300
4 reactions
(S)-malate+NAD(+)carbon dioxide+NADH(2-)+pyruvate
Reaction pageLeft to rightBalancedEC 1.1.1.38, 1.1.1.39mitochondrial matrix
Human-GEM MAR04087CC BY 4.0Reference data
(S)-malate+NADP(3-)carbon dioxide+NADPH(4-)+pyruvate
Catalysed by
2 names
Resolves to: ME2
Reaction pageLeft to rightBalancedEC 1.1.1.38, 1.1.1.40mitochondrial matrix
Human-GEM MAR04091CC BY 4.0Reference data
(S)-malate+NAD(1-)pyruvate+carbon dioxide+NADH(2-)
Catalysed by ME2
Reaction pageDirection not assertedBalanced
Rhea RHEA:12653CC BY 4.0Reference data
oxaloacetate+hydronpyruvate+carbon dioxide
Catalysed by ME2 or ME1 or ME3 or FAHD1
Reaction pageLeft to rightBalanced
Rhea RHEA:15641CC BY 4.0Reference data