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Reference

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A reference for what the literature reports. Not medical advice.

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nitric oxide

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

13 compounds within 3 steps: 2 in 1, 1 in 2, 10 in 3

Does it reach a compound?

One step

nitriteReach from here →
1. 4 nitric oxide + O2 + 2 H2O = 4 nitrite + 4 H(+)
Catalysed by CP
nitrateReach from here →
1. Fe(II)-heme b-[protein] + nitric oxide + O2 = Fe(III)-heme b-[protein] + nitrate
Catalysed by CYGB

Two steps

AReach from here →
1. 4 nitric oxide + O2 + 2 H2O = 4 nitrite + 4 H(+)
2. 2 nitrite + AH2 + 2 H(+) = 2 nitric oxide + A + 2 H2O
Catalysed by CP, SUOX

Three steps

betaine aldehydeReach from here →
Catalysed by CP, SUOX, CHDH
oxaloacetateReach from here →
Catalysed by CP, SUOX, D2HGDH

formaldehydeReach from here →

4 nitric oxide + O2 + 2 H2O = 4 nitrite + 4 H(+)
2 nitrite + AH2 + 2 H(+) = 2 nitric oxide + A + 2 H2O
N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 A + 2 H2O = L-lysyl(4)-[histone H3] + 2 formaldehyde + 2 AH2

Catalysed by CP, SUOX, KDM1A, KDM1BOne of 3 routes

all-trans-retinolReach from here →

4 nitric oxide + O2 + 2 H2O = 4 nitrite + 4 H(+)
2 nitrite + AH2 + 2 H(+) = 2 nitric oxide + A + 2 H2O
all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2

Catalysed by CP, SUOX, RETSAT

AH2Reach from here →

4 nitric oxide + O2 + 2 H2O = 4 nitrite + 4 H(+)
2 nitrite + AH2 + 2 H(+) = 2 nitric oxide + A + 2 H2O
A + NADH + H(+) = AH2 + NAD(+)

Catalysed by CP, SUOX, AIFM1, PYROXD1One of 19 routes

L-cysteineReach from here →

4 nitric oxide + O2 + 2 H2O = 4 nitrite + 4 H(+)
2 nitrite + AH2 + 2 H(+) = 2 nitric oxide + A + 2 H2O
Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

Catalysed by CP, SUOX, MOCOS

7,8-dihydrofolateReach from here →

4 nitric oxide + O2 + 2 H2O = 4 nitrite + 4 H(+)
2 nitrite + AH2 + 2 H(+) = 2 nitric oxide + A + 2 H2O
uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)

Catalysed by CP, SUOX, MTO1

a 2,3-dehydroacyl-CoAReach from here →

4 nitric oxide + O2 + 2 H2O = 4 nitrite + 4 H(+)
2 nitrite + AH2 + 2 H(+) = 2 nitric oxide + A + 2 H2O
a 2,3-saturated acyl-CoA + A = a 2,3-dehydroacyl-CoA + AH2

Catalysed by CP, SUOX, ACAD10

Fe(II)-heme aReach from here →

4 nitric oxide + O2 + 2 H2O = 4 nitrite + 4 H(+)
2 nitrite + AH2 + 2 H(+) = 2 nitric oxide + A + 2 H2O
Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2

Catalysed by CP, SUOX, COX15

Mo-molybdopterinReach from here →

4 nitric oxide + O2 + 2 H2O = 4 nitrite + 4 H(+)
2 nitrite + AH2 + 2 H(+) = 2 nitric oxide + A + 2 H2O
Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

Catalysed by CP, SUOX, MOCOS