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Proteins/UNIPROT:P00338
Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+)..
Function from UniProtKB (P00338), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
257 statements
257 statements · 6 reference databases · Subject: LDHA · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
6 reactions
3proton+23-hydroxypyruvic acid+NADH(2-)NAD(+)+2MAM03620c
Catalysed by LDHB or LDHA or LDHC or LDHAL6A or LDHD or LDHAL6B
Reaction pageLeft to rightUnbalancedEC 1.1.1.27cytosol
Human-GEM MAR01453CC BY 4.0Reference data
5 names
Resolves to: LDHA
Reaction pageReversibleBalancedEC 1.1.1.27peroxisome
Human-GEM MAR04281CC BY 4.0Reference data
proton+NADH(2-)+pyruvate(S)-lactic acid+NAD(+)
Catalysed by LDHB or LDHA or LDHC or LDHAL6A or LDHAL6B
Reaction pageReversibleBalancedEC 1.1.1.27cytosol
Human-GEM MAR04388CC BY 4.0Reference data
3-methyl-2-oxovaleric acid+proton+NADH(2-)NAD(+)+MAM03176c
Catalysed by LDHB or LDHA or LDHC or LDHD or LDHAL6B
Reaction pageReversibleBalancedEC 1.1.1.27cytosol
Human-GEM MAR11476CC BY 4.0Reference data
3-methyl-2-oxobutanoate+proton+NADH(2-)NAD(+)+MAM03186c
Catalysed by LDHB or LDHA or LDHC or LDHAL6A or LDHD or LDHAL6B
Reaction pageReversibleBalancedEC 1.1.1.27cytosol
Human-GEM MAR11479CC BY 4.0Reference data
(S)-lactate+NAD(1-)pyruvate+NADH(2-)+hydron
Catalysed by LDHA or LDHB or LDHC or LDHAL6A or LDHAL6B
Reaction pageReversibleBalanced
Rhea RHEA:23444CC BY 4.0Reference data