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Proteins/UNIPROT:P37059
Catalyzes the NAD-dependent oxidation of the highly active 17beta-hydroxysteroids, such as estradiol (E2), testosterone (T), and dihydrotestosterone (DHT), to their less active forms and thus regulates the biological potency of these steroids. Oxidizes estradiol to estrone, testosterone to androstenedione, and dihydrotestosterone to 5alpha-androstan-3,17-dione. Also has 20-alpha-HSD activity..
Function from UniProtKB (P37059), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
96 statements
96 statements · 7 reference databases · Subject: HSD17B2 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
9 reactions
androst-4-ene-3,17-dione+proton+NADPH(4-)NADP(3-)+testosterone
Catalysed by HSD17B6 or HSD17B2 or HSD17B1 or HSD17B3 or HSD17B7 or AKR1C3 or HSD17B11 or HSD17B8
Reaction pageLeft to rightBalancedEC 1.1.1.62, 1.1.1.64cytosol
Human-GEM MAR01973CC BY 4.0Reference data
10 names
Resolves to: HSD17B2
Reaction pageReversibleBalancedEC 1.1.1.62cytosol
Human-GEM MAR02036CC BY 4.0Reference data
estrone+proton+NADPH(4-)17beta-estradiol+NADP(3-)
Catalysed by HSD17B6 or HSD17B2 or HSD17B1 or HSD17B7 or HSD17B12 or HSD17B11 or HSD17B8
Reaction pageReversibleBalancedEC 1.1.1.62endoplasmic reticulum
Human-GEM MAR02041CC BY 4.0Reference data
androst-4-ene-3,17-dione+proton+NADH(2-)NAD(+)+testosterone
Catalysed by HSD17B6 or HSD17B2 or HSD17B8
Reaction pageLeft to rightBalancedEC 1.1.1.239endoplasmic reticulum
Human-GEM MAR07955CC BY 4.0Reference data
estrone+proton+NADH(2-)17beta-estradiol+NAD(+)
Catalysed by HSD17B6 or HSD17B2 or HSD17B1 or HSD17B7 or HSD17B12 or HSD17B11 or HSD17B8
Reaction pageLeft to rightBalancedEC 1.1.1.62, 1.1.1.64endoplasmic reticulum
Human-GEM MAR07968CC BY 4.0Reference data
testosterone+NAD(1-)androst-4-ene-3,17-dione+NADH(2-)+hydron
Catalysed by HSD17B6 or AKR1C4 or HSD17B2 or AKR1C3 or HSD17B8 or HSD17B10
Reaction pageLeft to rightBalanced
Rhea RHEA:14929CC BY 4.0Reference data
17beta-estradiol+NAD(1-)estrone+NADH(2-)+hydron
Catalysed by HSD17B6 or HSD17B1 or AKR1C4 or HSD17B2 or AKR1C3 or AKR1C2 or AKR1C1 or HSD17B12 or HSD17B13 or HSD17B11 or HSD17B8 or HSD17B10
Reaction pageReversibleBalanced
Rhea RHEA:24612CC BY 4.0Reference data
17beta-hydroxy-5alpha-androstan-3-one+NAD(1-)5alpha-androstan-3,17-dione+NADH(2-)+hydron
Catalysed by HSD17B2 or HSD17B8 or HSD17B10 or DHRS9
Reaction pageLeft to rightBalanced
Rhea RHEA:41992CC BY 4.0Reference data
(20S)-hydroxypregn-4-en-3-one+NAD(1-)progesterone+NADH(2-)+hydron
Catalysed by AKR1C4 or HSD17B2 or AKR1C3 or AKR1C2 or AKR1C1
Reaction pageDirection not assertedBalanced
Rhea RHEA:42108CC BY 4.0Reference data