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Proteins/UNIPROT:Q92781
Catalyzes the oxidation of cis-isomers of retinol, including 11-cis-, 9-cis-, and 13-cis-retinol in an NAD-dependent manner. Has no activity towards all-trans retinal (By similarity). Plays a significant role in 11-cis retinol oxidation in the retinal pigment epithelium cells (RPE). Also recognizes steroids (androsterone, androstanediol) as its substrates..
Function from UniProtKB (Q92781), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
2 rows
53 statements
53 statements · 6 reference databases · Subject: RDH5 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
11 reactions
9 names
Resolves to: RDH5
NAD(+)+all-trans-retinolproton+NADH(2-)+all-trans-retinal
Catalysed by HSD17B6 or RDH5 or SDR16C5 or ADH6 or ADH1A or ADH7 or ADH1B or ADH5 or ADH4 or ADH1C
Reaction pageLeft to rightBalancedEC 1.1.1.1, 1.1.1.105endoplasmic reticulum
Human-GEM MAR06633CC BY 4.0Reference data
11-cis-retinal+proton+NADH(2-)11-cis-retinol+NAD(+)
Catalysed by HSD17B6 or RDH5 or RDH16 or RLBP1 or DHRS4 or DHRS4L2 or RBP3
Reaction pageReversibleBalancedEC 1.1.1.105cytosol
Human-GEM MAR06638CC BY 4.0Reference data
9-cis-retinal+proton+NADH(2-)9-cis-retinol+NAD(+)
Catalysed by HSD17B6 or RDH5 or RDH16 or RLBP1 or DHRS4 or SDR16C5 or DHRS4L2 or ADH4 or RBP3
Reaction pageReversibleBalancedEC 1.1.1.105cytosol
Human-GEM MAR06644CC BY 4.0Reference data
11-cis-retinal+proton+NADPH(4-)11-cis-retinol+NADP(3-)
Catalysed by HSD17B6 or RDH5 or RDH16 or RLBP1 or DHRS4 or DHRS4L2 or RBP3
Reaction pageReversibleBalancedEC 1.1.1.105cytosol
Human-GEM MAR08709CC BY 4.0Reference data
13-cis-retinal+proton+NADH(2-)13-cis-retinol+NAD(+)
Catalysed by RDH5
Reaction pageReversibleBalancedEC 1.1.1.315cytosol
Human-GEM MAR08710CC BY 4.0Reference data
androsterone+NAD(1-)5alpha-androstan-3,17-dione+NADH(2-)+hydron
Catalysed by HSD17B6 or RDH16 or RDH5 or DHRS9
Reaction pageReversibleBalanced
Rhea RHEA:20381CC BY 4.0Reference data
5alpha-androstane-3alpha,17beta-diol+NAD(1-)17beta-hydroxy-5alpha-androstan-3-one+NADH(2-)+hydron
Catalysed by HSD17B6 or RDH16 or AKR1C4 or AKR1C3 or AKR1C2 or AKR1C1 or RDH5 or HSD17B10 or DHRS9
Reaction pageRight to leftBalanced
Rhea RHEA:42004CC BY 4.0Reference data
9-cis-retinol+NAD(1-)9-cis-retinal+NADH(2-)+hydron
Catalysed by RDH16 or ADH4 or ADH7 or RDH5
Reaction pageLeft to rightBalanced
Rhea RHEA:42052CC BY 4.0Reference data
13-cis-retinol+NAD(1-)13-cis-retinal+NADH(2-)+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:42056CC BY 4.0Reference data
11-cis-retinol+NAD(1-)11-cis-retinal+NADH(2-)+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:42060CC BY 4.0Reference data