Compound
2-methyl-3-oxopropanoic acid
The 2-methyl-3-oxo derivative of propanoic acid.
Definition from ChEBI (CHEBI:16256), read 2026-09-23. CC BY 4.0.
What it touches on the way
Mechanistic reach
9 entities
9 entities reached.
0 reported hops9 assembled from the scaffold
- ALDH2ProteinUNIPROT:P05091metabolized byInferred only64 paths32 endpoints
- ABATProteinUNIPROT:P80404substrate ofInferred only30 paths15 endpoints
- ALDH3A2ProteinUNIPROT:P51648metabolized byInferred only28 paths14 endpoints
- AOX1ProteinUNIPROT:Q06278metabolized byInferred only28 paths14 endpoints
- ALDH7A1ProteinUNIPROT:P49419metabolized byInferred only26 paths13 endpoints
- ALDH1B1ProteinUNIPROT:P30837metabolized byInferred only22 paths11 endpoints
- AGXT2ProteinUNIPROT:Q9BYV1substrate ofInferred only16 paths8 endpoints
- ALDH9A1ProteinUNIPROT:P49189metabolized byInferred only14 paths7 endpoints
- ALDH6A1ProteinUNIPROT:Q02252metabolized byInferred only12 paths6 endpoints
What the reference databases state
Chemical structure
- 2-methyl-3-oxopropanoic acid has the functional parent propionic acidCompoundChEBI CHEBI:16256Inferred only
Statements
22 statements
22 statements · 1 reference database · Subject: 2-methyl-3-oxopropanoic acid · Sources: Human-GEM
- 2-methyl-3-oxopropanoic acid is converted to (R)-3-aminoisobutyric acidCompoundHuman-GEM MAR03792Inferred only
- (R)-3-aminoisobutyric acid is converted to 2-methyl-3-oxopropanoic acidCompoundHuman-GEM MAR03792Inferred only
- 2-methyl-3-oxopropanoic acid is converted to (S)-3-amino-2-methylpropanoateCompoundHuman-GEM MAR08088Inferred only
- (S)-3-amino-2-methylpropanoate is converted to 2-methyl-3-oxopropanoic acidCompoundHuman-GEM MAR08088Inferred only
- 2-methyl-3-oxopropanoic acid is metabolised by ALDH1B1ProteinHuman-GEM MAR04797Inferred only
- 2-methyl-3-oxopropanoic acid is metabolised by ALDH1B1ProteinHuman-GEM MAR03759Inferred only
- 2-methyl-3-oxopropanoic acid is metabolised by ALDH2ProteinHuman-GEM MAR04797Inferred only
- 2-methyl-3-oxopropanoic acid is metabolised by ALDH2ProteinHuman-GEM MAR03759Inferred only
- 2-methyl-3-oxopropanoic acid is metabolised by ALDH3A2ProteinHuman-GEM MAR03759Inferred only
- 2-methyl-3-oxopropanoic acid is metabolised by ALDH3A2ProteinHuman-GEM MAR04797Inferred only
- 2-methyl-3-oxopropanoic acid is metabolised by ALDH6A1ProteinHuman-GEM MAR03761Inferred only
- 2-methyl-3-oxopropanoic acid is metabolised by ALDH6A1ProteinHuman-GEM MAR03795Inferred only
Show the remaining 10
- 2-methyl-3-oxopropanoic acid is metabolised by ALDH7A1ProteinHuman-GEM MAR04797Inferred only
- 2-methyl-3-oxopropanoic acid is metabolised by ALDH7A1ProteinHuman-GEM MAR03759Inferred only
- 2-methyl-3-oxopropanoic acid is metabolised by ALDH9A1ProteinHuman-GEM MAR04797Inferred only
- 2-methyl-3-oxopropanoic acid is metabolised by ALDH9A1ProteinHuman-GEM MAR03759Inferred only
- 2-methyl-3-oxopropanoic acid is metabolised by AOX1ProteinHuman-GEM MAR03790Inferred only
- 2-methyl-3-oxopropanoic acid is metabolised by AOX1ProteinHuman-GEM MAR03759Inferred only
- 2-methyl-3-oxopropanoic acid is a substrate of ABATProteinHuman-GEM MAR08088Inferred only
- 2-methyl-3-oxopropanoic acid is a substrate of ABATProteinHuman-GEM MAR03792Inferred only
- 2-methyl-3-oxopropanoic acid is a substrate of AGXT2ProteinHuman-GEM MAR03792Inferred only
- 2-methyl-3-oxopropanoic acid is a substrate of AGXT2ProteinHuman-GEM MAR03793Inferred only
Reactions
10 reactions
MAM00784m+NAD(+)2-methyl-3-oxopropanoic acid+proton+NADH(2-)
Catalysed by HSD17B10 or HIBADH
Reaction pageLeft to rightBalancedEC 1.1.1.31, 1.1.1.35GO:0005759
Human-GEM MAR03757CC BY 4.0Reference data
2-methyl-3-oxopropanoic acid+water+NAD(+)2proton+MAM02479m+NADH(2-)
Catalysed by ALDH3A2 or ALDH2 or ALDH1B1 or AOX1 or ALDH9A1 or ALDH7A1
Reaction pageLeft to rightBalancedEC 1.2.1.3, 1.2.3.1GO:0005759
Human-GEM MAR03759CC BY 4.0Reference data
2-methyl-3-oxopropanoic acid+CHEBI:1146900+NAD(+)(R)-methylmalonyl-CoA+proton+NADH(2-)
Catalysed by ALDH6A1
Reaction pageLeft to rightBalancedEC 1.2.1.18GO:0005759
Human-GEM MAR03761CC BY 4.0Reference data
2-methyl-3-oxopropanoic acid2-methyl-3-oxopropanoic acid
Reaction pageReversibleBalancedGO:0005829, GO:0005759
Human-GEM MAR03762CC BY 4.0Reference data
2-methyl-3-oxopropanoic acid+water+dioxygenproton+hydrogen peroxide+MAM02479c
Catalysed by AOX1
Reaction pageLeft to rightBalancedEC 1.2.3.1GO:0005829
Human-GEM MAR03790CC BY 4.0Reference data
2-methyl-3-oxopropanoic acid+L-glutamate(1-)2-oxoglutarate(2-)+(R)-3-aminoisobutyric acid
Reaction pageReversibleBalancedEC 2.6.1.22, 2.6.1.40GO:0005759
Human-GEM MAR03792CC BY 4.0Reference data
2-methyl-3-oxopropanoic acid+L-alanine(R)-3-aminoisobutyric acid+pyruvate
Catalysed by AGXT2
Reaction pageReversibleBalancedEC 2.6.1.40GO:0005759
Human-GEM MAR03793CC BY 4.0Reference data
2-methyl-3-oxopropanoic acid+CHEBI:1146900+NAD(+)carbon dioxide+NADH(2-)+propionyl-CoA
Catalysed by ALDH6A1
Reaction pageLeft to rightBalancedEC 1.2.1.27GO:0005759
Human-GEM MAR03795CC BY 4.0Reference data
2-methyl-3-oxopropanoic acid+water+NAD(+)2proton+MAM02479c+NADH(2-)
Catalysed by ALDH3A2 or ALDH2 or ALDH1B1 or ALDH9A1 or ALDH7A1
Reaction pageLeft to rightBalancedEC 1.2.1.3GO:0005829
Human-GEM MAR04797CC BY 4.0Reference data
2-methyl-3-oxopropanoic acid+L-glutamate(1-)2-oxoglutarate(2-)+(S)-3-amino-2-methylpropanoate
Catalysed by ABAT
Reaction pageReversibleBalancedEC 2.6.1.22GO:0005759
Human-GEM MAR08088CC BY 4.0Reference data
Other names
3 names
Resolves to: 2-methyl-3-oxopropanoic acid
- Also called
- 2-Methyl-3-oxopropanoate3-Oxo-2-methylpropanoateMethylmalonate semialdehyde