15(S)-HPETE

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

107 compounds within 3 steps: 3 in 1, 7 in 2, 97 in 3

One step

(15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoateReach from here →
1. palmitoyl-CoA hydrolase (15(S)-HPETE)
No catalyst recordedcytosol
(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. Glutathione: 15-HPETE oxidoreductase
Catalysed by GPX5, GPX1, GPX2, GPX3 and 5 morecytosol
glutathione disulfideReach from here →
1. Glutathione: 15-HPETE oxidoreductase
Catalysed by GPX5, GPX1, GPX2, GPX3 and 5 morecytosol

Two steps

(5S)-hydroperoxy-(15S)-hydroxy-(6E,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. Glutathione: 15-HPETE oxidoreductase
2. (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + O2 = (5S)-hydroperoxy-(15S)-hydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate
Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol
L-cystineReach from here →
1. Glutathione: 15-HPETE oxidoreductase
2. cystine to cysteine conversion
Catalysed by GPX5, GPX1, GPX2, GPX3 and 5 more

Three steps

cytosol

CHEBI:16856Reach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 5 morecytosolOne of 8 routes

methylarsonateReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol

thiosulfateReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol

15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 5 morecytosolOne of 3 routes

glutathioneReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosolOne of 4 routes

Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol

tauroursodeoxycholateReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, extracellular spaceOne of 3 routes

glycoursodeoxycholateReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, extracellular spaceOne of 3 routes

(11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoateReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 26 morecytosolOne of 5 routes

prostaglandin E3Reach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol, extracellular spaceOne of 2 routes

prostaglandin A2Reach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol, extracellular spaceOne of 2 routes

prostaglandin B1Reach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol, extracellular spaceOne of 2 routes

leukotriene F4Reach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 5 morecytosol, extracellular spaceOne of 2 routes

prostaglandin A2-S-(R)-glutathioneReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 8 morecytosol

prostaglandin A2-S-(S)-glutathioneReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 8 morecytosol

prostaglandin J2-S-(R)-glutathioneReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 9 morecytosol

prostaglandin J2-S-(S)-glutathioneReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 8 morecytosol

2,4-dinitrophenyl-S-glutathioneReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 10 morecytosol

(13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoateReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 8 morecytosol

S-methyl glutathioneReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol

L-cystine-bis-glycineReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol

S-adenosylglutathioneReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol

acetylcholineReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, extracellular spaceOne of 2 routes

pyruvateReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol

(S)-malateReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, mitochondrial matrixOne of 2 routes

L-leucineReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, extracellular space

CHEBI:15650Reach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol, extracellular spaceOne of 2 routes

bromideReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 22 morecytosolOne of 2 routes

a halide anionReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 29 morecytosol

sulfateReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosolOne of 3 routes

lithocholic acidReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, extracellular spaceOne of 2 routes

L-arginineReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol, inner side of the membrane, outer side of the membrane

bilirubin IXalphaReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, extracellular spaceOne of 2 routes

taurolithocholateReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, extracellular spaceOne of 2 routes

CHEBI:17208Reach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 5 morecytosol

homocysteineReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 5 morecytosol

sulfiteReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosolOne of 6 routes

L-cysteineReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 5 morecytosolOne of 4 routes

urateReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, inner side of the membrane, outer side of the membrane

methylarsonous acidReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 8 morecytosolOne of 2 routes

fumaric acidReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, mitochondrial matrixOne of 2 routes

thiocyanateReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 8 morecytosol, mitochondrial matrixOne of 2 routes

arsenic triglutathioneReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosolOne of 3 routes

15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathioneReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol