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Proteins/UNIPROT:P56192
Catalyzes the specific attachment of L-methionine to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Plays a role in the synthesis of ribosomal RNA in the nucleolus. In addition, can prevent the misincorporation of homocysteine into tRNA and protein by catalyzing a tRNA-independent hydrolysis of the misactivated homocysteinyl-AMP intermediate. The homocysteinyl-AMP intermediate undergoes an intramolecular cyclization reaction in which the thiolate side chain of homocysteine displaces the AMP group, forming homocysteine-thiolactone and AMP (By similarity)..
Function from UniProtKB (P56192), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
3 rows
262 statements
262 statements · 8 reference databases · Subject: MARS1 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
6 reactions
ATP+L-methionine+MAM03075cAMP+Met-tRNA(Met)+diphosphate(3-)
Catalysed by MARS1
Reaction pageLeft to rightBalance undeterminableEC 6.1.1.10cytosol
Human-GEM MAR05143CC BY 4.0Reference data
ATP+selenomethionine+MAM03075cAMP+diphosphate(3-)+MAM02893c
Catalysed by
3 names
Resolves to: MARS1
Reaction pageLeft to rightBalance undeterminableEC 6.1.1.10cytosol
Human-GEM MAR07620CC BY 4.0Reference data
CHEBI:78442+L-methionine+ATP(4-)CHEBI:78530+AMP+diphosphate(3-)
Reaction pageDirection not assertedBalanced
Rhea RHEA:13481CC BY 4.0Reference data
L-homocysteine+ATP(4-)L-homocysteine thiolactone+AMP+diphosphate(3-)
Catalysed by MARS1
Reaction pageLeft to rightBalanced
Rhea RHEA:83875CC BY 4.0Reference data
L-homocysteine+ATP(4-)+hydronL-homocysteinyl-AMP+diphosphate(3-)
Catalysed by MARS1
Reaction pageLeft to rightBalanced
Rhea RHEA:83879CC BY 4.0Reference data
L-homocysteinyl-AMPL-homocysteine thiolactone+AMP+hydron
Catalysed by MARS1
Reaction pageLeft to rightBalanced
Rhea RHEA:83883CC BY 4.0Reference data