urea

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

119 compounds within 3 steps: 2 in 1, 10 in 2, 107 in 3

One step

cyanamideReach from here →
1. urea = cyanamide + H2O
Catalysed by CA1, CA2
urateReach from here →
1. Peroxidase
Catalysed by MPOnucleusOne of 3 routes

Two steps

(S)-lactateReach from here →
1. Peroxidase
2. urate(out) + (S)-lactate(in) = urate(in) + (S)-lactate(out)
Catalysed by MPO, SLC22A12, SLC22A13nucleus, inner side of the membrane, outer side of the membrane
CHEBI:17208Reach from here →
1. Peroxidase
2. ascorbate to monodehydroascorbate conversion
Catalysed by MPOnucleus, cytosol
xanthineReach from here →

Three steps

2-hydroxybutyric acidReach from here →
Catalysed by MPO, SLC22A12, SLC16A4, SLC16A5 and 5 morenucleus, extracellular space, cytosolOne of 2 routes
2-phenylpropan-2-olReach from here →

Peroxidase

xanthine + NAD(+) + H2O = urate + NADH + H(+)

Catalysed by MPO, XDHnucleusOne of 2 routes

5-hydroxyisourateReach from here →

Catalysed by MPOnucleus, cytosol

a dicarboxylateReach from here →

Catalysed by MPO, SLC22A6nucleus, inner side of the membrane, outer side of the membraneOne of 2 routes

glutarateReach from here →

Catalysed by MPO, SLC22A8nucleus, inner side of the membrane, outer side of the membraneOne of 2 routes

nicotinateReach from here →

Catalysed by MPO, SLC22A12, SLC22A13nucleus, inner side of the membrane, outer side of the membrane

(S)-lactic acidReach from here →

Catalysed by MPO, SLC22A12nucleus, extracellular space, cytosol

glutathioneReach from here →

Catalysed by MPO, SLC22A13nucleus, inner side of the membrane, outer side of the membrane

CHEBI:730073Reach from here →

Catalysed by MPOnucleusOne of 3 routes

Catalysed by MPO, SLC22A13, CLIC2, GPX1 and 2 morenucleus, inner side of the membrane, outer side of the membrane

a hydroxy polyunsaturated fatty acidReach from here →

Catalysed by MPO, SLC22A13, GPX1, GPX2 and 1 morenucleus, inner side of the membrane, outer side of the membrane

tauroursodeoxycholateReach from here →

Catalysed by MPO, SLC22A13, ABCC4nucleus, inner side of the membrane, outer side of the membrane

glycoursodeoxycholateReach from here →

Catalysed by MPO, SLC22A13, ABCC4nucleus, inner side of the membrane, outer side of the membrane

(15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoateReach from here →

Catalysed by MPO, SLC22A13, GPX1, GPX4nucleus, inner side of the membrane, outer side of the membrane

(11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoateReach from here →

Catalysed by MPO, SLC22A13, GSTP1, GSTM1 and 1 morenucleus, inner side of the membrane, outer side of the membrane

prostaglandin E3Reach from here →

Catalysed by MPO, SLC22A12nucleus, extracellular space, cytosolOne of 4 routes

prostaglandin A2Reach from here →

Catalysed by MPO, SLC22A12nucleus, extracellular space, cytosolOne of 2 routes

prostaglandin J2Reach from here →

Catalysed by MPO, SLC22A12nucleus, extracellular space, cytosolOne of 2 routes

15-oxoprostaglandin F2alphaReach from here →

Catalysed by MPO, SLC22A12nucleus, extracellular space, cytosolOne of 2 routes

prostaglandin A2-S-(R)-glutathioneReach from here →

Catalysed by MPO, SLC22A13, GSTA1, GSTM1nucleus, inner side of the membrane, outer side of the membrane

prostaglandin A2-S-(S)-glutathioneReach from here →

Catalysed by MPO, SLC22A13, GSTP1, GSTM1nucleus, inner side of the membrane, outer side of the membrane

prostaglandin J2-S-(R)-glutathioneReach from here →

Catalysed by MPO, SLC22A13, GSTA1, GSTP1 and 1 morenucleus, inner side of the membrane, outer side of the membrane

prostaglandin J2-S-(S)-glutathioneReach from here →

Catalysed by MPO, SLC22A13, GSTP1, GSTM1nucleus, inner side of the membrane, outer side of the membrane

2,4-dinitrophenyl-S-glutathioneReach from here →

Catalysed by MPO, SLC22A13, PTGES, LANCL1 and 2 morenucleus, inner side of the membrane, outer side of the membrane

acetoacetateReach from here →

Catalysed by MPO, SLC22A12, SLC16A4, SLC16A5 and 3 morenucleus, extracellular space, cytosolOne of 2 routes

(13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoateReach from here →

Catalysed by MPO, SLC22A13, GSTM4, LTC4Snucleus, inner side of the membrane, outer side of the membrane

S-methyl glutathioneReach from here →

Catalysed by MPO, SLC22A13, MMACHCnucleus, inner side of the membrane, outer side of the membrane

indoxyl sulfateReach from here →

Catalysed by MPO, SLC22A6, SLC22A8nucleus, inner side of the membrane, outer side of the membraneOne of 2 routes

S-adenosylglutathioneReach from here →

Catalysed by MPO, SLC22A13, MMACHCnucleus, inner side of the membrane, outer side of the membrane

pyruvateReach from here →

Catalysed by MPO, SLC22A12, LDHB, LDHAL6Bnucleus, extracellular space, cytosol, mitochondrial matrixOne of 7 routes

all-trans-retinoic acidReach from here →

Catalysed by MPO, SLC22A12, SLC16A4, SLC16A5 and 4 morenucleus, extracellular space, cytosolOne of 2 routes

allantoinReach from here →

Catalysed by MPOnucleus, cytosol

a halide anionReach from here →

Catalysed by MPO, SLC22A13, GSTT4, GSTA4 and 21 morenucleus, inner side of the membrane, outer side of the membrane

sulfateReach from here →

Catalysed by MPO, SLC22A6, SLC25A35, SLC25A34nucleus, inner side of the membrane, outer side of the membraneOne of 2 routes

(R)-carnitineReach from here →

Catalysed by MPO, SLC22A8nucleus, inner side of the membrane, outer side of the membraneOne of 2 routes

N-[(S)-lactoyl]-L-phenylalanineReach from here →

Catalysed by MPO, SLC22A12, SLC22A13, CNDP2nucleus, inner side of the membrane, outer side of the membrane

ferrocytochrome cReach from here →

Catalysed by MPO, SLC22A12, CYB5D1nucleus, extracellular space, cytosol, mitochondrial matrix

(R)-3-hydroxybutyric acidReach from here →

Catalysed by MPO, SLC22A12, SLC16A4, SLC16A5 and 3 morenucleus, extracellular space, cytosolOne of 2 routes

nicotinamideReach from here →

Catalysed by MPO, SLC22A12, SLC22A13, CD38nucleus, inner side of the membrane, outer side of the membrane

itaconateReach from here →

Catalysed by MPO, SLC22A8, SUGCTnucleus, inner side of the membrane, outer side of the membrane

dehydroascorbic acidReach from here →

Catalysed by MPOnucleus, cytosolOne of 18 routes

3-hydroxy-3-methylglutarateReach from here →

Catalysed by MPO, SLC22A8, SUGCTnucleus, inner side of the membrane, outer side of the membrane

sulfiteReach from here →

Catalysed by MPO, SLC22A13, TSTD1nucleus, inner side of the membrane, outer side of the membraneOne of 2 routes

hypoxanthineReach from here →

Catalysed by MPO, XDHnucleus

methylarsonous acidReach from here →

Catalysed by MPO, SLC22A13, GSTO1, GSTO2nucleus, inner side of the membrane, outer side of the membrane

xanthosineReach from here →

Catalysed by MPO, XDH, PNPnucleus, cytosol